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Рациональная фармакотерапия в кардиологии
Scopus
ISSN 1819-6446 · Столичная издательская компания · 3.366 artikel di indeks
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Artikel Jurnal
Impact of treatment adherence on survival during long-term follow-up in patients after acute myocardial infarction: data from the PROFILE-IM registry
Aim. To assess the impact of treatment adherence on long-term outcomes over a ten-year period in patients with acute myocardial infarction (MI) based on data from the prospective PROFILE-MI registry.Material and methods. The prospective PROFILE-IM registry included 160 patients attended a…
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Artikel Jurnal
Carriage of CYP2C19 gene alleles and possible drug-drug interactions in patients with coronary artery disease
Aim. To analyse the frequencies of the CYP2C19 gene alleles and genotypes associated with the metabolism of antiplatelet agents in patients with coronary artery disease (CAD), considering potential drug-drug interactions in real clinical practice in Arkhangelsk.Material and methods. The…
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Artikel Jurnal
The effect of an exogenous source of nitrate ions – beetroot powder – on blood pressure and arterial stiffness in a pilot preclinical study
Aim. Тo conduct a preclinical trial of the effect of beetroot powder (Beta-NO-BOOST), as an exogenous source of nitrate and nitrite ions (NOx), on blood pressure (BP) and arterial stiffness in patients with arterial hypertension (AH).Material and methods. The pilot preclinical study included 22…
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A comparative study of the therapeutic equivalence (efficacy, safety, and tolerability) and pharmacokinetics of brand-name and generic rivaroxaban in patients with non-valvular atrial fibrillation
Aim. To study the therapeutic equivalence (efficacy, safety, and tolerability) and pharmacokinetics of the brand-name and generic rivaroxaban 20 mg in patients with non-valvular atrial fibrillation and a high risk of thromboembolic complications.Material and methods. This open-label, randomized…
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Artikel Jurnal
Patients with combination of coronary artery disease and chronic kidney disease in clinical practice: comorbidities and cardiovascular pharmacotherapy
Aim. To define the proportion of comorbid chronic kidney disease (CKD) in the cohort of patients with coronary artery disease (CAD) and to estimate the incidence of comorbidities and required cardiovascular pharmacotherapy on a basis of united data from several medical registries.Material and…
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Conduction disorders as an early marker of cardiac glycogenosis (PRKAG2 syndrome)
The article presents a clinical case of familial PRKAG2-cardiomyopathy, illustrating diagnostic challenges and the importance of molecular genetic verification. A comprehensive clinical and instrumental examination of the proband and close relatives was performed, along with whole-exome sequencing…
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Safety of using the intravenous beta-1-adrenoblocker esmolol in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute…
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Association of rare gene variants associated with low bone mass and dyslipidemia with the combination of atherosclerosis and osteopenic syndrome in women
Aim. To study the associations of rare gene variants involved in monogenic diseases presenting with low bone mineral density (BMD) and dyslipidemia, with combined vascular wall and bone tissue changes in women.Material and methods. The study included 308 peri- and postmenopausal women aged 45 to 82…
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Integration of biobanking technologies into protocols of large-scale prospective epidemiological studies
Aim. To demonstrate successful experience in the development and implementation of biobanking methods for epidemiological research in the Russian Federation (RF), as well as the application of biobanking technology and the participation of a biobank created on the basis of the national medical…
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Artikel Jurnal
Assessment of the features of follow-up and implementation of treatment and preventive measures in patients with prediabetes in outpatient clinical practice in the Russian Federation (DIORAMA): rationale and study design
Aim. To assess the features of clinical follow-up (dispensary observation) and the implementation of preventive measures among patients with prediabetes in the context of outpatient clinical practice.Material and methods. The DIORAMA study (Features of dispensary observation and implementation of…
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Artikel Jurnal
From SCORE2 to SCORE2-RF: development of a Russian model for cardiovascular risk stratification
Aim. To validate the European SCORE2 scale for assessing the 10-year risk of fatal and non-fatal cardiovascular events in the Russian population and to develop an adapted local version of the scale (SCORE2-RF) with defined thresholds for risk stratification.Material and methods. The analysis was…
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Artikel Jurnal
Polycystic ovary syndrome and cardiovascular disease risk
Aim. To define and discuss the main pathogenic mechanisms of polycystic ovary syndrome (PCOS) and its association with cardiometabolic risk factors.Material and methods. The material for this nonsystematic review was collected from peer-reviewed articles published in PubMed, eLibrary.RU…
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Artikel Jurnal
Extreme hypertriglyceridemia: frequency of occurrence, clinical aspects, and efficacy of different therapeutic approaches
Aim. To evaluate the prevalence, clinical features, and effectiveness of various lipid-lowering therapy (LLT) regimens in patients with extreme hypertriglyceridemia (EHTG).Material and methods. A retrospective analysis of a database comprising 170,640 patients from a cardiology inpatient unit and…
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Artikel Jurnal
Pharmacotherapy safety and treatment nonadherence: an ambiguous alliance (data from an outpatient registry)
Aim. To analyze data on adverse drug reactions (ADRs) from medical history and assess pharmacotherapy (PT) adherence among patients within an outpatient registry. This study aims to investigate the relationship between these variables and determine their potential priority.Material and methods. A…
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Artikel Jurnal
Associations of composite mental health assessment scales with cardiovascular diseases and mortality in population aged 55 years and older
Aim. To develop new composite mental health assessment scales integrating indicators of psycho-emotional and cognitive functioning, and to analyze their associations with cardiovascular diseases (CVD) and mortality in population aged 55 and older.Material and methods. The study was conducted as…
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Artikel Jurnal
Efficacy and risk factors for recurrence of atrial fibrillation after radiofrequency ablation of the pulmonary vein orifices
Aim. To compare the efficacy of pulmonary vein radiofrequency ablation (RFA) in patients with atrial fibrillation (AF) between two temporal cohorts (2016-2018 and 2021-2022) and to identify factors affecting the likelihood of arrhythmia recurrence.Material and methods. The study sequentially…
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Artikel Jurnal
The role of CYP2C19 gene nucleotide sequence variants in assessing response to P2Y12 receptor inhibitor antiplatelet therapy in old patients with acute coronary syndrome
Aim. To assess the association between carrying CYP2C19 polymorphic variants and response to antiplatelet therapy, evaluated by residual platelet reactivity (Platelet Reactivity Units, PRU), in patients from different age groups.Material and methods. The study included 140 patients with ACS…
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Artikel Jurnal
Assessment of Wnt1 and Wnt3a levels in patients with different phenotypes of stable coronary artery disease
Aim. To assess the Wnt1 and Wnt3a proteins levels in patients with stable coronary artery disease (CAD) and different phenotypes of coronary artery lesions.Material and methods. A cross-sectional study included 72 patients with a verified diagnosis of stable CAD (aged 45-75 years) and 30 healthy…
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Artikel Jurnal
Plasma concentrations of factor Xa inhibitors and stroke risk in patients with atrial fibrillation
Aim. To determine plasma concentrations of direct oral anticoagulants (DOACs) in patients with ischemic stroke (IS) associated with atrial fibrillation (AF) and to compare them with DOAC levels in patients with AF but without IS receiving similar therapy. Material and methods. A prospective cohort…
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Artikel Jurnal
The role of the metabotropic glutamate receptor 1 signaling pathway in the development of cardiovascular pathology
Metabotropic glutamate receptor 1 (mGluR1), traditionally studied in the context of neuronal signaling, has recently gained attention as a potential contributor to the pathogenesis of cardiovascular diseases. This review summarises current evidence on the role of mGluR1 in neurodegenerative…
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