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Cancer Nanotechnology
Scopus
ISSN 1868-6958 · BMC · 373 artikel di indeks
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Artikel Jurnal
Exosome-encapsulated perfluorocarbon nanoprobes for precise imaging and persistent monitoring of liver metastasis
Abstract Background Liver metastasis (LM) remains a leading cause of cancer mortality, and conventional magnetic resonance imaging (MRI) is susceptible to physiological interference, which affects the diagnostic accuracy of LM. Fluorine-19 (¹⁹F) MRI offers a promising solution due to its negligible…
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Artikel Jurnal
Harnessing nanotechnology: ellipticine nanoformulations in the fight against cancer
Abstract Ellipticine is a naturally occurring alkaloid that is derived from the plants of Apocynaceae family and has gained a lot of attention for its promising anticancer properties. Its therapeutic activity is linked with many mechanisms, like oxidative activation, DNA intercalation and…
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Artikel Jurnal
Anti-glioma efficacy of Quercetin-Iron nanodots with peroxidase-mimicking activity and photothermal conversion capability
Abstract Glioma remains one of the most aggressive brain tumors, necessitating innovative therapeutic strategies. Quercetin (Que), a natural polyphenolic flavonoid, has shown potential in cancer treatment. It can form iron-based nanodots (Que-Fe) that exhibit peroxidase (POD)-mimicking activity…
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Artikel Jurnal
Iron–quercetin complex reprograms tumor-associated macrophages toward M1 phenotype and enables MRI tracking in ex vivo tumor-mimicking spheroids
Abstract Background Tumor-associated macrophages (TAMs) frequently adopt an M2-like, immunosuppressive state that promotes tumor growth and therapy resistance. Reprogramming TAMs toward a pro-inflammatory M1 phenotype is a promising strategy to remodel the tumor microenvironment (TME) and enhance…
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Artikel Jurnal
“Three-birds-one-stone” environment responsive delivery system with tumor microenvironment remodeling to enhance solid tumor therapy
Abstract Unique tumor microenvironment (TME), tumor cell reprogramming and tumor tissues wrapped by rigid extracellular matrix (ECM), these natural physiological barriers can compromise solid tumor treatment. In this study, we constructed a “three-birds-one-stone” delivery system…
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Artikel Jurnal
NIR-activated phase-transition thermal-propagation nanosystem for precision photothermal eradication of malignant melanoma
Abstract Multidrug resistance and the acidic tumor microenvironment (TME) of malignant melanoma significantly limit the efficacy of conventional therapies. In this study, we constructed a near-infrared (NIR)-responsive thermosensitive phase-transition core–shell nanosystem (CaO-DOX-IR820@DLTP)…
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Artikel Jurnal
Recent advances in phytomedicine-based nano-antioxidants for redox-modulated cancer therapy
Abstract Reactive oxygen species play a key and paradoxical role in tumor progression biology. At physiological levels, ROS act as important signaling molecules that control growth, survival, and metabolism. This redox balance becomes disrupted in cancer, leading to chronically elevated ROS levels…
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Artikel Jurnal
Selaginella doederleinii–derived extracellular vesicle-like particles induce ferroptosis via the xCT/GPX4 axis and are associated with metabolic and gut microbiota alterations in hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide, and the limited efficacy and adverse effects of current therapeutic strategies highlight the urgent need for safer and more effective anticancer approaches. Selaginella doederleinii, a…
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Artikel Jurnal
Luteolin-based nanocomposites in cancer: rewiring oncogenic signaling and non-coding RNA networks to restore programmed cell death
Abstract Luteolin, a naturally occurring flavonoid abundant in vegetables and medicinal plants, is increasingly recognized for its anticancer potential through pleiotropic effects on cellular signaling and gene expression. Recent research highlights its capacity to modulate multiple oncogenic…
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Artikel Jurnal
Efficacy of nanomaterials in the treatment of head and neck cancer: a systematic review
Abstract The prevalence of head and neck cancer is increasing, raising concerns regarding the rate of recovery, recurrence, and aggressive surgical approaches that have negatively impacted patient welfare. In this context, nanomedicine has emerged as a promising alternative, offering a progressive…
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Artikel Jurnal
Receptor selection in targeted small extracellular vesicles: comparative evaluation of EGFR- and NTSR1-mediated drug delivery in hepatocellular carcinoma
Abstract Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality. Moreover, the clinical utility of conventional chemotherapies is limited by systemic toxicity and poor tumor selectivity. Receptor-targeted small extracellular vesicles (sEVs) represent a…
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Artikel Jurnal
Self-assembled orlistat–Fe(III) nanoparticles amplify ferroptosis for enhanced tumor therapy
Abstract Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation and reactive oxygen species (ROS) accumulation. Herein, we report a novel metal-coordinated nanoparticle system (OFe-NPs) fabricated via a one-pot self-assembly between orlistat and FeCl3·6…
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Artikel Jurnal
TME-responsive switch-on nano-contrast for targeted BBB-traversing MRI of glioma
Abstract Background MRI for intracranial lesions has unsatisfactory signal-to-noise ratios due to BBB (Blood Brain Barrier) obstruction and the rapid metabolism of contrast agent molecules. A pH-sensitive nanosystem can cloak Gd3+ from protons in normal tissues and activate Gd3+ signals in acidic…
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Artikel Jurnal
Redox-responsive cisplatin-loaded cerium oxide nanozymes for oral squamous cell carcinoma: oxidative stress modulation, anti-inflammatory activity, and enhanced cytotoxicity
Abstract Oral squamous cell carcinoma (OSCC) is known to inadequate therapies outcomes due to low efficacy and inflammatory toxicity of conventional chemotherapy. Herein, this study was developed cisplatin-loaded cerium oxide nanozymes (Cis@CeO₂ NZs) as a multi-functional platform to improve the…
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Artikel Jurnal
Biomimetic nanozymes for tumor diagnosis and treatment
Abstract As a major global health threat, cancer continues to pose significant challenges for diagnosis and treatment. Nanozymes are nanomaterials that mimic the catalytic functions of natural enzymes while offering high stability and tunable activity, thereby providing a novel perspective for…
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Artikel Jurnal
Sustainable nanomedicine: exploiting fruit and vegetable waste-derived extracts for targeted anticancer application
Abstract Background Despite significant advances in oncology, cancer therapy remains constrained by systemic toxicity, limited tumor selectivity, and the progressive emergence of drug resistance. These limitations have intensified interest in multi-target, biologically active compounds with…
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Artikel Jurnal
Nanometal-mediated cuproptosis and ferroptosis: emerging paradigms in hepatocellular carcinoma therapy
Abstract Hepatocellular carcinoma is associated with substantial global mortality. Hepatocellular carcinoma ranks among the leading causes of cancer-related mortality worldwide, underscoring an urgent unmet clinical need (Llovet et al. 2021). Most patients still don’t survive beyond two years…
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Artikel Jurnal
Nano-enabled delivery of natural products and combinatorial chemotherapy for triple-negative breast cancers: mechanisms, synergy, and translational challenges
Abstract Among breast cancer subtypes, Triple-negative breast cancer (TNBC) is recognized for its aggressive behavior and is characterized by the absence of hormone receptors (estrogen and progesterone) and HER2 overexpression. This absence results in fewer treatment options and less favorable…