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Journal of Ophthalmic Inflammation and Infection
Scopus
ISSN 1869-5760 · SpringerOpen · 472 articles in the index
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Journal Article
Topical mycophenolate for the treatment of uveitis-associated inflammation
Abstract Objective Uveitis refers to the inflammation of the uveal tract of the eye (iris, ciliary body and choroid). In the developed world, it accounts for 10–15% of all cases of blindness. Anterior uveitis accounts is the most common form of uveitis. There is an unmet need for a topically…
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Journal Article
Putative mechanisms of ocular inflammation in syphilis
Abstract Background Ocular syphilis is re-emerging globally as a cause of uveitis, with the potential for substantial vision loss. Multimodal ophthalmic imaging and advanced laboratory research can yield important information about the basic mechanisms of this infectious eye disease. Review…
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Journal Article
Evaluation of corneal intrastromal voriconazole injection as an adjuvant approach in recalcitrant fungal keratitis
Abstract Background Fungal keratitis is a sight-threatening condition that accounts for approximately 30–40% of keratitis cases in developing countries. Its management remains challenging despite the availability of various antifungal agents, highlighting the potential role of targeted drug…
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Journal Article
Secondary punctate inner choroidopathy in an RP2 associated retinopathy female carrier
Abstract Purpose To describe a case of punctate inner choroidopathy (PIC) occurring in a RP2 associated Retinopathy female carrier, highlighting the diagnostic contribution of multimodal imaging and the therapeutic course. Methods Observational case report with multimodal retinal imaging…
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Journal Article
Utility of the Collaborative Ocular Tuberculosis Study (COTS) calculator in the management of a case of frosted branch angiitis secondary to presumed intraocular tuberculosis - a case report
Abstract Aim To illustrate the application of the Collaborative Ocular Tuberculosis Study (COTS) calculator in guiding the management of a case of frosted branch angiitis (FBA) secondary to presumed intraocular tuberculosis (TB). Methods Retrospective case report. Results A 33-year-old Indonesian…
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Journal Article
Contribution of 16S rRNA gene PCR to microbiological diagnosis of endophthalmitis: a retrospective clinical cohort study of 71 vitreous and aqueous humor samples
Abstract Background Culture remains the reference method for microbiological diagnosis of endophthalmitis, but its sensitivity is limited by small sample volumes, prior antibiotics, and fastidious organisms. This study evaluates the diagnostic contribution of 16S rRNA gene-targeted polymerase chain…
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Journal Article
Unilateral orbital mass as the initial presentation of pediatric antineutrophil cytoplasmic antibody associated vasculitis: eosinophilic granulomatosis with polyangiitis versus granulomatosis with polyangiitis
Abstract Background Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a rare antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis characterized by asthma, eosinophilia, and systemic vasculitis. Ocular involvement is uncommon (6–20%) and…
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Journal Article
Ultra-widefield retinal imaging for early detection of asymptomatic cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation: a prospective pilot feasibility study
Abstract Background To evaluate the feasibility and potential clinical utility of ultra-widefield (UWF) retinal imaging as a screening strategy for the early detection of asymptomatic cytomegalovirus retinitis (CMVR) in patients with systemic cytomegalovirus (CMV) viremia after allogeneic…
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Journal Article
Ocular toxoplasmosis in Latin American and European patients: clinical characteristics, visual outcomes, and recurrence patterns
Abstract Background Ocular toxoplasmosis is the most common cause of posterior uveitis worldwide and a major cause of visual impairment. Previous studies suggest that the disease may follow a more aggressive clinical course in patients from Latin America; however, direct comparative evidence…
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Journal Article
Late-onset optic disc swelling-type Vogt–Koyanagi–Harada disease: diagnostic value of longitudinal multimodal imaging
Abstract Purpose To describe an atypical late-onset presentation of Vogt–Koyanagi–Harada (VKH) disease initially interpreted as autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) in association with an ovarian teratoma. Methods A 59-year-old woman presented with bilateral optic disc…
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Journal Article
Nocardia brasiliensis endophthalmitis initially misdiagnosed as uveitis: a case report
Abstract Background Endophthalmitis caused by Nocardia brasiliensis is extremely rare and typically affects immunocompromised individuals, frequently leading to severe vision loss due to diagnostic delays. We report a case of N. brasiliensis endophthalmitis in an older man without prior history of…
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Journal Article
Severe corneal melting with necrotic sloughing in Acanthamoeba keratitis mimicking corneal endotheliitis
Abstract Background Acanthamoeba keratitis (AK) is a sight-threatening corneal infection that may initially lack typical epithelial or perineural findings and mimic other infectious or inflammatory anterior segment disorders. Endotheliitis-like presentations of AK with stromal edema, keratic…
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Journal Article
Delayed-onset cytomegalovirus retinitis after 0.2 µg/day fluocinolone acetonide implantation: a case series
Abstract Purpose To describe the clinical features and outcomes of cytomegalovirus retinitis (CMVR) presenting after intravitreal fluocinolone acetonide (FAc) implantation. Methods Single centre, retrospective observational case series involving three patients who developed CMVR several months…
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Journal Article
Comparative long-term outcomes of conventional immunomodulatory therapy, biologic agents, and combination therapy in chronic uveitis
Abstract Background Chronic non-infectious uveitis can lead to vision loss if not adequately controlled. Thus, steroid-sparing immunomodulatory therapy (IMT) is often required to achieve and maintain disease quiescence. It is unclear if biologic agents inhibiting tumor necrosis factor alpha (TNF-α)…
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Journal Article
A rare case of multisystem autoimmune disease presenting with retinopathy and alopecia post COVID-19 vaccination
Abstract Purpose To report a case of autoimmune retinopathy (AIR) with multiple systemic involvement Results A 45-year-old Asian Indian male presented with progressive blurring of vision in the right eye for five years. Initial best-corrected visual acuity (BCVA) was 20/80 in RE and 20/25 in LE…
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Journal Article
Sarcoidosis presenting as fulminant bilateral multifocal choroiditis
Abstract Purpose To report a case of fulminant bilateral multifocal choroiditis as the presenting manifestation of sarcoidosis despite normal serum angiotensin-converting enzyme (ACE) and unremarkable thoracic imaging. Case presentation An immunocompetent 32-year-old man was admitted with a…
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Journal Article
Aspergillus keratitis presenting with an immune ring: a case report and literature review
Abstract Purpose To describe the clinical presentation, diagnostic challenges, and management of fungal keratitis (FK) caused by Aspergillus spp. presenting with a delayed immune-like ring infiltrate. Methods We report a case describing the clinical course, diagnostic workup, and treatment of a…
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Journal Article
Clinical profile of microsporidial keratoconjunctivitis in healthy individuals of China —new species and neglected risk factors
Abstract Objective To characterize microsporidial keratoconjunctivitis (MKC) in immunocompetent individuals in Mainland China, including novel etiologies and risk factors. Methods A prospective analysis of 20 MKC patients in 2025, including clinical features, pathogens (via corneal scrapings and…
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Journal Article
Culture-proven endogenous endophthalmitis: ocular and systemic clinical features and outcomes
Abstract Purpose To report the clinical presentation, systemic associations, microbiologic spectrum, management strategies, and treatment outcomes of patients with culture-proven endogenous endophthalmitis. Methods A retrospective review of medical records was conducted of patients with…
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Journal Article
Eosinophilic esophagitis is associated with increased risk of allergic conjunctivitis: a multicenter cohort study
Abstract Background Eosinophilic esophagitis (EoE) is a chronic, Th2-driven inflammatory esophageal disease frequently associated with atopic disorders. However, ocular comorbidities in EoE, particularly allergic conjunctivitis, have not been well characterized. In this study, we compare the…