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Virus Research
Scopus
ISSN 1872-7492 · Elsevier · 621 artikel di indeks
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Artikel Jurnal
Identification of key genes modules linking brain aging signatures and COVID-19-associated cognitive impairment
Background: Emerging evidence indicates that SARS-CoV-2 infection is associated with aging, particularly in memory-related domains. However, the molecular mechanisms underlying COVID-19-associated aging, often referred to as ''brain fog,'' remain poorly understood. This study aimed to identify key…
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Artikel Jurnal
Investigation of chikungunya arbovirus in cities of Bushehr province: An ELISA-based cross-sectional study
Background: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus transmitted by Aedes aegypti and Aedes albopictus. Despite favorable ecological conditions in southern Iran, data on CHIKV exposure in Bushehr Province are lacking. This study aimed to determine the seroprevalence of…
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Impacts of delayed influenza vaccination on clinical outcomes in ICU-admitted patients with influenza: A retrospective cohort study
Background: Influenza vaccination is an effective measure for reducing the risk of severe influenza infection. However, the task of achieving adequate vaccination rates remains a global challenge. It is unclear whether delayed influenza vaccination is useful for influenza patients. We conducted…
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PCBP2 inhibits antiviral innate immune responses via the MAVS-mediated signaling pathway in severe fever with thrombocytopenia syndrome
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease with high mortality and limited therapeutic options. Poly(rC)-binding protein 2 (PCBP2) is a multifunctional RNA-binding protein involved in post-transcriptional regulation and innate immune…
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Artikel Jurnal
Engineered soluble truncated envelope proteins block bovine leukemia virus infection
Bovine leukemia virus (BLV), a member of the delta retrovirus family, is transmitted horizontally among cows. BLV causes enzootic bovine leukosis and has great economic impact on the cattle industry. Recently, secretory-defective Env proteins (e.g., Refrex-1 and FeLIX) have been detected in…
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NDV-GT wth hyperacute rejection in cancer therapy
Oncolytic viruses (OVs) represent a promising immunotherapy for cancer treatment, though their clinical application is often limited by systemic toxicity and low immunogenicity. To address this, we developed NDV-GT, a genetically engineered Newcastle disease virus that encodes porcine…
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RAB25 promotes hepatitis B virus-induced liver fibrosis progression through activation of the PI3K/AKT signaling pathway
Abstracts: Despite the clinical possibility of reducing hepatitis B virus (HBV) to almost undetectable levels through nucleotide analogs or interferon, the process of hepatic fibrosis in HBV hepatitis carriers perdures. This study will investigate the function of RAB25 in HBV-induced liver fibrosis…
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Revelation of core promoter elements and bidirectional regulation of Geminivirus genes in Escherichia coli
Several geminiviruses have been show to possess cross-kingdom gene expression capability. In addition, the intergenic region (IR) of geminivirus genomes is known to regulate the transcription of viral early genes (complementary-sense, C-sense) and late genes (virion-sense, V-sense) located in…
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Merkel Cell Polyomavirus in colorectal cancer: exploring the Wnt/β-catenin pathway
Merkel cell polyomavirus (MCPyV) is the established oncogenic driver of Merkel cell carcinoma (MCC), but its role in other malignancies is under investigation. Although MCPyV DNA has been detected in colorectal cancer (CRC) specimens, its biological relevance and contribution to colorectal…
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An IMS 1313-based inactivated PRV vaccine with a novel immunopotentiator induces robust protective immunity against virulent variants
Background: Pseudorabies virus (PRV) variants have emerged as major swine pathogens associated with high piglet mortality and reproductive losses in China since 2011. Conventional oil-adjuvant vaccines are effective but frequently induce adverse local reactions. Water-soluble adjuvants, such as the…
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Targeting NF-κB signaling for HIV latency reversal: Mechanisms, challenges, and therapeutic perspectives
HIV latency remains a major barrier to achieving a definitive cure, as replication-competent proviruses persist in resting CD4⁺ T cells despite prolonged antiretroviral therapy (ART). The nuclear factor kappa B (NF-κB) signaling pathway plays a central role in both latency maintenance and viral…
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Clinical impact of baloxavir-induced PA I38T/M substitutions in diverse influenza populations: a systematic review and meta-analysis
Background: Seasonal influenza imposes substantial clinical and economic burdens, with pediatric populations facing escalating risks of severe complications. While baloxavir marboxil (baloxavir) is an efficacious cap-dependent endonuclease inhibitor, the emergence of treatment-induced PA I38T/M…
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Calu-3 cells as novel efficient cell culture system for Borna disease virus 1 (BoDV-1)
Borna disease virus 1 (BoDV-1) is the causative agent of zoonotic infections resulting in severe encephalitis with a high case-fatality rate in humans. To search for an efficient in-vitro cell culture system for the generation of BoDV-1 virus stocks, we compared different human cell lines (A549…
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Expression and immunogenicity of a rabies virus glycoprotein–HSV-2 ICP35 fusion antigen delivered by an mRNA–LNP formulation
Rabies virus (RABV) is a zoonotic pathogen with an almost 100% case-fatality rate and limited post-exposure prophylaxis options. mRNA-based antigen delivery represents a promising approach but requires further optimization. We prepared a cationic lipid nanoparticle (LNP) delivery system using the…
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Expanded virome analysis of metatranscriptomes from grapevine downy mildew lesions reveals novel viral segments, novel viruses and viroid-like RNAs
Grapevine downy mildew, caused by the obligate biotrophic oomycete Plasmopara viticola, represents a major constraint to viticulture worldwide. Previous metatranscriptomic analyses revealed an unexpectedly rich viral diversity associated with downy mildew leaf lesions and in this study we…
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CRISPR-Cas systems as precision antimicrobials: Reversing the tide of antimicrobial resistance
Antimicrobial resistance (AMR) has escalated into a global health crisis, with resistant pathogens causing over 1.2 million direct deaths annually and threatening to render modern medicine unsustainable. This review provides a comprehensive and updated synthesis of CRISPR-Cas-based antimicrobial…
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The PTM switches of HBx: Master regulators of HBV infection and liver oncogenesis
The hepatitis B virus (HBV) X protein (HBx) functions as a versatile regulatory molecule that is indispensable for both efficient HBV replication and the pathogenesis of HBV-related hepatocellular carcinoma (HCC). Accumulating studies indicate that a broad spectrum of post-translational…