63 results

Hallmarks of cancer stemness

Jia-Jian Loh; Stephanie Ma

Cell stem cell · 2024 · English · OpenAlex Scopus

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

Ruzhica Bogeska; Ana‐Matea Mikecin; Paul Kaschutnig et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Caroline B. Pantazis; Andrian Yang; Erika Lara et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research groups. To address this issue, we sub-cloned candidate…

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Matheus B. Victor; Noelle Leary; Xochitl Luna et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

Reciprocal regulation of mesenchymal stem cells and immune responses

Ying Wang; Jiankai Fang; Benming Liu et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

Wound healing, fibroblast heterogeneity, and fibrosis

Heather Elizabeth desJardins-Park; Shamik Mascharak; Michelle Griffin et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

Shamik Mascharak; Heather Elizabeth desJardins-Park; Michael Januszyk et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair

Elise C. Jeffery; Terry L.A. Mann; Jade A. Pool et al.

Cell stem cell · 2022 · English · OpenAlex Scopus

bone marrow stromal cells that expressed hematopoietic niche factors at fracture sites. Different bone injuries are thus repaired by different SSCs, with periosteal cells regenerating bone and marrow stroma after non-stabilized fractures.

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

Ram Prosad Chakrabarty; Navdeep S. Chandel

Cell stem cell · 2021 · English · OpenAlex Scopus

CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

Cheng Wang; Yang Li; Lingfei Jia et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

Daniel Hormaechea‐Agulla; Katie A. Matatall; Duy Tri Le et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Ary Marsee; Floris J.M. Roos; Monique M. A. Verstegen et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Capturing human trophoblast development with naive pluripotent stem cells in vitro

Shingo Io; Mio Kabata; Yoshiki Iemura et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Human naive epiblast cells possess unrestricted lineage potential

Ge Guo; Giuliano Giuseppe Stirparo; Stanley E. Strawbridge et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Classic embryological experiments have established that the early mouse embryo develops via sequential lineage bifurcations. The first segregated lineage is the trophectoderm, essential for blastocyst formation. Mouse naive epiblast and derivative embryonic stem cells are restricted accordingly…

Establishment, maintenance, and recall of inflammatory memory

Samantha B. Larsen; Christopher J. Cowley; Sairaj M. Sajjath et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jitske Jansen; Katharina C. Reimer; James Shiniti Nagai et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To…

Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy

Mauro Krampera; Katarina Le Blanc

Cell stem cell · 2021 · English · OpenAlex Scopus

Naive stem cell blastocyst model captures human embryo lineage segregation

Ayaka Yanagida; Daniel J. Spindlow; Jennifer Nichols et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and hypoblast. Here we describe a human embryo model (blastoid) generated by self-organization. Brief induction of trophectoderm leads to formation of blastocyst-like structures within 3 days. Blastoids are composed…

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

Adam Ramzy; David M Thompson; Kirsten A. Ward‐Hartstonge et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Jérôme Mertens; Joseph R. Herdy; Larissa Traxler et al.

Cell stem cell · 2021 · English · OpenAlex Scopus

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent neuronal model. AD patient-derived iNs exhibit strong neuronal transcriptome signatures characterized by downregulation…