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Journal of Parkinson’s Disease
Scopus
ISSN 1877-7171 · SAGE Publishing · 1.833 artikel di indeks
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Artikel Jurnal
Analysis of α-synuclein seed amplification assay in carriers of and pathogenic variants
Background The α-synuclein seed amplification assay (αS-SAA) represents a promising strategy for identifying individuals with α-synuclein pathology, empowering development of tailored Parkinson's disease (PD) therapeutics and clinical trial design. Objective To assess the αS-SAA in cerebrospinal…
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Artikel Jurnal
A monoclonal antibody-based immunoassay reinforces DOPA decarboxylase in cerebrospinal fluid as a diagnostic biomarker for Parkinson's disease with potential prognostic value
Background Proteomic studies have identified cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker candidate for Parkinson's disease (PD). The aim of this study was to develop an immunoassay for CSF DDC quantification and gain further insight into its potential as a biomarker…
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Artikel Jurnal
Anxiety is associated with increased risk of suicidality in Parkinson's disease
Background Suicide risk in Parkinson's disease (PD) remains understudied, with limited exploration of the impact of neuropsychiatric comorbidities and commonly prescribed PD and psychiatric medications. Objective To investigate the prevalence and correlates of suicide risk in PD. Methods This study…
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Artikel Jurnal
Pharmacological inhibition of O-GlcNAcase reduces pS129-α-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice
Background The aggregation and spread of α-synuclein within brain are associated with the loss of dopaminergic neurons and the formation of Lewy bodies as seen in Parkinson's disease. Blocking the initiation of α-synuclein aggregation, or the spread of such aggregates, may offer disease-modifying…
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Artikel Jurnal
Serum phosphorylated tau 217 in variant carriers with and without Parkinson disease
It is unclear whether Alzheimer disease pathology drives cognitive decline in Parkinson disease (PD) patients carrying GBA1 variants. We evaluated levels of serum phosphorylated tau 217 (p-tau217) in samples from 29 GBA1 -PD, 32 idiopathic PD, 20 non-manifesting GBA1 variant carriers ( GBA1 -NMC)…
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Artikel Jurnal
Can transcranial Direct Current Stimulation enhance the efficacy of a rehabilitative intervention for the treatment of Freezing of Gait in Parkinson's disease? A double-blind, randomized controlled study
Background Freezing of gait (FOG) in Parkinson's disease (PD) is a major cause of disability and falls and often responds incompletely to conventional therapy. Rehabilitative interventions including cognitive strategies and sensory cueing are efficacious, but difficulties in learning impair…
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Artikel Jurnal
Exercise-Induced modulation of molecular-enriched functional connectivity in Parkinson's disease
Parkinson's disease (PD) involves degeneration of dopaminergic neurons and dysfunction across multiple neurotransmitter systems, contributing to both motor and cognitive impairments. Aerobic exercise improves clinical outcomes; however, its underlying neural mechanisms remain unclear. Using…
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Artikel Jurnal
Faster reaction times of CSF alpha-synuclein seed amplification assay predict the diffuse malignant subtype of Parkinson's disease at 10-year follow-up
Background Data-driven approaches identified Mild Motor Predominant (MMP), Intermediate (IM), and Diffuse Malignant (DM) as Parkinson's Disease (PD) subtypes with different motor and non-motor impairment at diagnosis. It remains unclear whether these subtypes remain stable over time or whether they…
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Artikel Jurnal
VR-based quantitative oculomotor analysis and association with regional brain atrophy in MSA
Background The quantitative assessment of the oculomotor system has emerged as a promising biomarker for neurodegenerative disorders. Although oculomotor impairments are commonly observed in multiple system atrophy (MSA) patients, the specific abnormalities and underlying neural structural changes…
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Artikel Jurnal
Development and acceptability of a deep brain stimulation surgery decision aid for Parkinson's disease
Background The decision to undergo deep brain stimulation (DBS) surgery for patients with Parkinson's disease (PD) is often challenging and complex. Decisional outcomes may be improved by using decisional support tools that foster shared decision making. Objective The objective of this study was to…
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Artikel Jurnal
Dual-Risk axis: mutations and occupational pesticide exposure in Parkinson's disease
Background Occupational pesticide (OcP) exposure and pathogenic GBA1 variants are established risk factors for Parkinson's disease (PD). However, whether they interact to influence disease onset or severity remains uncertain. Objective To determine the prevalence of OcP exposure and other lifestyle…
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Artikel Jurnal
Longitudinal change in swallow function in patients with Parkinson's disease (PD)
Objective Parkinson's disease (PD) frequently involves dysphagia, yet real-world longitudinal data capturing its progression and response to clinical care remain limited. Most prior studies exclude treated patients or rely solely on subjective or cross-sectional data. This study investigates…
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Artikel Jurnal
Creation of a machine learning-based model for early identification of mild cognitive impairment risk in Parkinson's disease: A PD research center-based population study
Background This study aimed to use data from the PD-MDCNC database to develop a risk prediction model using machine learning (ML) methods for the early identification of the risk of mild cognitive impairment in Parkinson's disease (PD-MCI) within a Parkinson's disease (PD) patients cohort. Methods…
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Artikel Jurnal
Quantitative measures of total and phosphorylated alpha-synuclein in skin tissue as potential biomarkers for synucleinopathies
Background Alpha-synuclein can be detected in skin biopsies of individuals with synucleinopathies. However, quantitative data of total and phosphorylated Serine 129 (pS129) alpha-synuclein in skin biopsies are scarce. Objective We aimed to investigate the biomarker potential of quantitative total…
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Artikel Jurnal
A modified Delphi consensus study to support and enhance Parkinson's disease management
Background Levodopa is still the cornerstone of symptomatic treatment for people with Parkinson's disease (PwP). With disease progression and long-term use, PwP can develop motor complications such as wearing off and dyskinesia. There is limited practical guidance on the early identification of…
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Artikel Jurnal
Early bone health assessment is indicated in Parkinson's: Risk factor analysis in a UK population-based cohort study
Background Osteoporosis and major osteoporotic fracture are more common in PD than controls, but evaluation of sociodemographic factors and preventive treatment is limited. Methods In a UK population-based nested case-control study, incidence rates of osteoporosis and major osteoporotic fracture…
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Artikel Jurnal
Handwriting patterns in isolated rapid eye movement sleep behaviour disorder
Background Handwriting changes are recognised as an early manifestation of Parkinson's disease. Whilst isolated rapid eye movement sleep behaviour disorder (iRBD) is strongly associated with future Parkinson's diagnosis, changes in handwriting remain under-explored. Objective To assess the…
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Artikel Jurnal
Telerehabilitation for early-stage Parkinson's disease: A randomized controlled feasibility trial of individualised real-time physiotherapy delivered via a videoconference platform
Introduction Exercise can improve outcomes for people with Parkinson's. Telerehabilitation (TR) may lower costs and maximise clinician time but its efficacy for gait and balance in early Parkinson's is uncertain. We conducted a randomized controlled feasibility trial of individualised real-time…
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Artikel Jurnal
High intensity interval training for Parkinson's disease: A scoping review of systemic effects and physiological adaptations
Background High intensity interval training (HIIT) involves vigorous intensity exercise bouts interspersed with low intensity bouts. Despite growing interest, the optimal dosage and clinical adaptability of HIIT in Parkinson's disease (PD) remain unclear. This scoping review synthesized the…
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Artikel Jurnal
Cultural and systemic barriers in Parkinson's disease diagnosis, treatment, and research participation among Asian Americans: A qualitative study
Introduction Despite being the fastest-growing ethnic group in the United States, Asian Americans, encompassing all ethnic subgroups, remain notably underrepresented in Parkinson's Disease (PD) research and clinical trials. This qualitative study seeks to address this gap by exploring how Asian…
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