395 hasil
Menampilkan 1–20 · 0,15 detik · RSS
Inflammation and Regeneration
Scopus
ISSN 1880-8190 · BMC · 395 artikel di indeks
-
Artikel Jurnal
Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells
Abstract Background Super-enhancers (SEs), characterized by dense clusters of enhancer elements enriched with transcriptional activator binding sites, are involved in cell differentiation. However, little is known about SE-mediated regulation of adipogenic genes. The aim of this study was to…
-
Artikel Jurnal
Granzyme A-producing type 1 innate lymphoid cells promote salivary secretion in the aged submandibular gland
Abstract Background Salivary gland function declines with age, contributing to periodontitis and aspiration pneumonia. However, the cellular mechanisms that preserve secretion during aging remain unclear. Methods Mice were stratified by aging stage, and saliva output and tissue histology were…
-
Artikel Jurnal
Enhanced nerve regeneration after transplantation of NCAM-positive neural crest-like cells derived from human iPSC
Abstract Background Peripheral nerve injuries often cause persistent sensory and motor deficits, and autologous nerve grafting, the current standard, is limited by donor site morbidity and tissue availability. Human induced pluripotent stem cells (hiPSCs)-derived neural crest-like cells (NCLCs)…
-
Artikel Jurnal
Diagnostic potential of cryptic exon-derived peptides in serum extracellular vesicles for sporadic amyotrophic lateral sclerosis
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration and loss of upper and lower motor neurons, with approximately 90% of cases being sporadic (sporadic ALS, SALS). A reliable diagnostic biomarker remains an unmet clinical need in…
-
Artikel Jurnal
Lysophosphatidic acid promotes cutaneous wound healing through vascular maturation and fibroblast activation in a murine model
Abstract Background Impaired cutaneous wound healing is a major clinical burden, particularly among older individuals and patients with diabetes. Lysophosphatidic acid (LPA) is a bioactive phospholipid with known roles in cell proliferation, migration, and vascular formation; however, its…
-
Artikel Jurnal
Exploring cartilage development and disease models: applications of cartilage organoids
Abstract Cartilage is an avascular and aneural connective tissue vital for joint function, yet its limited intrinsic regenerative capacity poses significant challenges for treating injuries and degenerative diseases such as osteoarthritis (OA). Conventional models—including animal studies, cell…
-
Artikel Jurnal
Modeling striatal development and disease with human pluripotent stem cells
Abstract The striatum plays a central role in motor control, cognition, reward processing, and habit formation, and its dysfunction is implicated in a broad spectrum of neurological and psychiatric disorders. Although animal models have provided important insights into striatal development and…
-
Artikel Jurnal
Advancement of humanized mice and leading applications in immunological disease models
Abstract Disease models are used to evaluate drug candidates, and compounds that are highly effective in vivo models have traditionally been prioritized for development. While conventional ‘gold standard’ animal models have been central to autoimmune drug discovery, there is increasing recognition…
-
Artikel Jurnal
PAFAH2 deficiency drives sepsis-induced vascular leakage by promoting ECHS1-mediated suppression of protein crotonylation and mitochondrial dysfunction
Abstract Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The vascular endothelial cells (VECs) play a pivotal role in the progression of sepsis-induced vascular leakage. While therapeutic strategies targeting pathogen elimination and…
-
Artikel Jurnal
Generation of therapeutic T cells from human induced pluripotent stem cells
Abstract T cell exhaustion remains a critical barrier in treating chronic infections and cancer. To overcome this, our laboratory has established a platform for generating “rejuvenated” T cells from induced pluripotent stem cells (iPSCs). This review outlines our research trajectory, transitioning…
-
Artikel Jurnal
Th9 cells at the intersection of IBD and colorectal cancer: a context-dependent factor in carcinogenesis
Abstract The differentiation of naïve T cells into the Th9 phenotype is driven by the synergistic effects of IL-4 and TGF-β, leading to the secretion of their hallmark cytokine, interleukin-9 (IL-9). Known for their critical roles in mucosal immunopathology, Th9 cells are particularly prominent in…
-
Artikel Jurnal
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells
Abstract Background Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a mitochondria-derived peptide, is known to regulate…
-
Artikel Jurnal
Allogeneic skin transplantation induces transient fibrosis that undergoes spontaneous regression in newts
Abstract Background In humans, large skin defects require tissue transplantation because adult skin lacks full regenerative capacity. However, allogeneic grafts are typically rejected due to strong immune responses, whereas autologous grafts often result in severe fibrosis and permanent scarring…
-
Artikel Jurnal
Autoreactive B cells in systemic lupus erythematosus: insights from integrative multi-omics analyses
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoantibodies and deposition of immune complexes. SLE presents with heterogeneous multi-organ involvement that varies among patients and its mechanisms have been investigated to facilitate…
-
Artikel Jurnal
Safety and efficacy profile of S-005151 (Redasemtide), in patients with chronic liver diseases: phase 2 trial
Abstract Background and aims Cirrhosis is a disease of impaired liver function and fibrosis caused by long-term liver damage. However, to date, no drugs have been approved to improve liver fibrosis. We report the results of a phase 2 study of S-005151 (generic name: Redasemtide), a partial peptide…
-
Artikel Jurnal
Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes
Abstract Tissue-resident memory T cells (TRMs) are a non-circulating subset of memory T cells that reside long-term in peripheral tissues. Once considered passive sentinels, TRMs are now recognized as active regulators of transplant immunity. This review summarizes their phenotypic and functional…
-
Artikel Jurnal
Effects of intranasal long-acting insulin pretreatment on postoperative delirium and the NLRP3/caspase-1/IL-1β pathway in older patients with esophageal cancer
Abstract Background Insulin exhibits neuroprotective and anti-inflammatory properties. Preoperative intranasal insulin preconditioning is a potential strategy to prevent postoperative delirium (POD), but prior studies mainly used rapid-acting formulations. This investigation focused on intranasal…
-
Artikel Jurnal
Amphiregulin attenuates sepsis-induced myocardial dysfunction by maintaining the localization of connexin43
Abstract Background Sepsis-induced myocardial dysfunction (SIMD) is a prevalent complication among septic patients, significantly worsening patient prognosis and elevating the mortality rate. Connexin 43 (Cx43), a pivotal cardiac gap junction protein, maintains cardiac function, and its…