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Cell Host & Microbe
Scopus
ISSN 1931-3128 · Cell Press · 76 artikel di indeks
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Intestinal mucus and their glycans: A habitat for thriving microbiota
The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. In the…
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Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
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Phages and their satellites encode hotspots of antiviral systems
Bacteria carry diverse genetic systems to defend against viral infection, some of which are found within prophages where they inhibit competing viruses. Phage satellites pose additional pressures on phages by hijacking key viral elements to their own benefit. Here, we show that E. coli P2-like…
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Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2
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An expanded arsenal of immune systems that protect bacteria from phages
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SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape
Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 strain that evolved over 6 months from ancestral virus in a person with advanced HIV disease in South Africa; this person…
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Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from…
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Role of dietary fiber in the recovery of the human gut microbiome and its metabolome
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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19
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Human gut bacterial metabolism drives Th17 activation and colitis
Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains elusive. We show that human gut Actinobacterium Eggerthella lenta induces intestinal Th17 activation by lifting inhibition of the Th17…