2.818 hasil
Menampilkan 1–20 · 1,82 detik · RSS
Translational Oncology
Scopus
ISSN 1936-5233 · Elsevier · 2.818 artikel di indeks
-
Artikel Jurnal
Magrolimab (Hu5F9-G4) promotes macrophage M1 polarization and is associated with enhanced autophagy in colorectal cancer
Background: The role of macrophage infiltration in colorectal cancer (CRC) and its implications for prognosis remains uncertain. While macrophage immune checkpoint inhibitors have shown efficacy in treating solid tumors, their impact on CRC progression and immune regulation is unclear. Purpose…
-
Artikel Jurnal
MTA1 upregulation enhances stemness and chemoresistance of gastric cancer cells
Objective: MTA1 (Metastasis-associated protein 1) is implicated in various malignancies, but its role in gastric cancer (GC) stemness and chemoresistance remains unclear. This study explores the effect of MTA1 on these processes and its underlying mechanisms. Methods: MTA1 expression was assessed…
-
Artikel Jurnal
Unveiling shared PANoptosis mechanisms in LUAD and osteoarthritis via bioinformatics and machine learning
Lung adenocarcinoma (LUAD) and osteoarthritis (OA) pose significant therapeutic challenges due to their invasive heterogeneity and limited treatment options. This study investigates PANoptosis-related genes in LUAD and OA to develop a prognostic risk model using bioinformatics and machine learning…
-
Artikel Jurnal
HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT
Background: Metastasis is a major cause of treatment failure and poor prognosis in lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) plays a crucial role in promoting LUAD metastasis. Pulmonary sarcomatoid carcinoma (PSC), a highly aggressive non-small cell lung cancer subtype…
-
Artikel Jurnal
Nuclear factor E2 p45-related factor (NRF2) and peroxiredoxin 6 tissular expression as prognostic biomarkers for advanced HPV-negative squamous cell carcinoma of the oropharynx
Objectives: Non-HPV-induced squamous cell carcinomas (SCC) of the oropharynx have a poorer prognosis than HPV-induced cancers because they are more radio- and chemoresistant. Currently, no predictive biomarker exists for survival outcome in this type of tumor. NRF2 is a nuclear transcription factor…
-
Artikel Jurnal
Integrative multi-omics of matched primary and liver metastatic colorectal cancer organoids identifies putative molecular targets
Hepatic metastasis from colorectal cancer (CRC) mainly accounts for the dismal prognosis of advanced CRC. Metastasized tumor cells exhibit strong resistance to commonly used systemic chemotherapy, which causes the high mortality of colorectal liver metastasis (CLM) patients. Although previous…
-
Artikel Jurnal
Utilization of ultrasound combined with Ki-67 and CESM quantitative parameters to predict pathological complete response following neoadjuvant chemotherapy in triple-negative breast cancer
Objective: To evaluate the predictive value of ultrasound parameters combined with Ki-67 and contrast-enhanced spectral mammography (CESM) for assessing pathological complete response (pCR) following neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC). Methods: This retrospective…
-
Artikel Jurnal
Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis
Background: Osteosarcoma is a primary malignant bone tumor that primarily affects adolescents and children, is highly metastatic and invasive, and has a poor survival prognosis. P3H2 is a basement membrane-associated tumor suppressor gene that is down-regulated in some types of tumors. Although…
-
Artikel Jurnal
Development of multiple cell death pattern features to predict prognosis and drug sensitivity in gastric adenocarcinoma
Background: Regulated cell death (RCD) pathways play a crucial role in stomach adenocarcinoma (STAD), influencing apoptosis and potentially offering new therapeutic opportunities. This study aimed to analyze the immune microenvironment, mutation landscape, and develop a prognostic framework based…
-
Artikel Jurnal
Establishment and characterization of preclinical models of human gynecologic tract carcinosarcomas demonstrates targetable FGFR1 alterations
Objective: Gynecologic carcinosarcoma is an uncommon but aggressive malignancy that frequently requires systemic therapy but therapeutic options are limited. Development of preclinical models is therefore important for therapeutic advancement. Methods: Carcinosarcoma tumor (6 uterine and 1…
-
Artikel Jurnal
Development and validation of a nomogram for predicting the risk of malignancy in intraductal papillary neoplasms: a retrospective study
Objective: Development and validation of a simple, accurate nomogram for predicting the risk of malignancy in intraductal papillary neoplasms (IPNs). Background: Some studies have explored the independent risk factors associated with malignant IPNs, but no validated predictive model has been…
-
Artikel Jurnal
Evolution of conditioning regimens prior to autologous stem cell transplantation in lymphoma patients
High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has become the standard salvage treatment for primary high-risk and relapsed/refractory lymphoma patients. The conditioning regimen has evolved from one that included total body irradiation (TBI) to one that includes…
-
Artikel Jurnal
Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in multiple myeloma
Multiple myeloma (MM) is a challenging hematologic malignancy with increasing incidence. Cuproptosis, a copper-dependent form of cell death associated with mitochondrial metabolism and protein lipoylation, remains unexplored in MM. This study aims to investigate this connection using transcriptome…
-
Artikel Jurnal
Dynamic assessment of proliferation to guide response-adapted therapy in the setting of neoadjuvant chemotherapy in ER+/HER2- breast cancer
Biomarkers for evaluating response to neoadjuvant chemotherapy (NACT) in ER+/HER2− breast cancer remain limited. This study explores the impact of NACT on tumor proliferation dynamics and its association with relapse-free interval (RFI) among 175 patients with early ER+/HER2− breast tumors…
-
Artikel Jurnal
ITLN1, orchestrated by the IFNγ-IRF1 axis, suppresses hepatocellular carcinoma proliferation via ERK1/2 activation
Background: Intelectin 1 (ITLN1) is a recently discovered secretory adipokine with pivotal functions in the innate immune system, inflammation, and the facilitation of glucose uptake. Nonetheless, its exact functions in hepatocellular carcinoma (HCC) remain not fully elucidated. Methods: In this…
-
Artikel Jurnal
Clinical significance and molecular mechanism of CDX2-CBX3 regulatory axis in lung adenocarcinoma progression
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, with chemotherapy resistance and tumor heterogeneity posing significant challenges. The Chromobox (CBX) protein family, crucial epigenetic regulators in tumor progression, has not been systematically characterized in…
-
Artikel Jurnal
Nutritional strategies against skeletal muscle wasting in cancer-associated cachexia: the role of β-hydroxybutyrate and polyunsaturated fatty acids
Cachexia is a multifactorial syndrome that occurs in many cancers, particularly in their advanced stages, decreasing the quality of life and lifespan of patients. One of the hallmarks of cancer-associated cachexia is skeletal muscle wasting. Multiple causes include inflammation, metabolic…
-
Artikel Jurnal
MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway
Background: Esophageal cancer (ESCA) remains difficult to treat with surgery and chemotherapy showing limited impact on patient prognosis. Matrix metalloproteinase 11 (MMP11) has been linked to tumor progression and immune microenvironment modulation. This study explored MMP11′s role in regulating…
-
Artikel Jurnal
Aurintricarboxylic acid, an inhibitor of cystathionine γ-lyase, enhances the sensitivity of chemotherapy drugs in TNBC
The current treatments for triple-negative breast cancer (TNBC) rely mainly on chemotherapy. Enhancing the effect of chemotherapy drugs or exploring new targeted drugs is expected to provide more treatment options for patients with TNBC. Our previous studies have shown that the…
-
Artikel Jurnal
Development of a single-cell derived MDSCs signature score for prognostic risk stratification and therapeutic decision guidance in breast cancer
Background: Myeloid-derived suppressor cells (MDSCs) function as critical immunosuppressive constituents within the breast cancer tumor microenvironment (TME). However, their molecular variability and clinical translation potential remain inadequately characterized. Methods: By combining…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.