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Science Signaling
Scopus
ISSN 1937-9145 · American Association for the Advancement of Science · 4 artikel di indeks
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Artikel Jurnal
An atlas of human metabolism
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We…
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Artikel Jurnal
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Biased agonism at G protein-coupled receptors describes the phenomenon whereby some drugs can activate some downstream signaling activities to the relative exclusion of others. Descriptions of biased agonism focusing on the differential engagement of G proteins versus β-arrestins are commonly…
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Artikel Jurnal
Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration
The progression of inflammation-associated colon cancer is driven by resident bacteria.
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Artikel Jurnal
4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
hematologic malignancies. 4-1BB-costimulated CAR (BBζ) T cells exhibit longer persistence after adoptive transfer than do CD28-costimulated CAR (28ζ) T cells. 4-1BB signaling improves T cell persistence even in the context of 28ζ CAR activation, which indicates distinct prosurvival signals mediated…