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Frontiers in Bioscience-Scholar
Scopus
ISSN 1945-0516 · IMR Press · 141 artikel di indeks
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Artikel Jurnal
Sex-Dependent Association of SMAD3 Gene Polymorphisms With Asthma and Allergy Risk in Russian Children
Background: Despite significant advances in identifying susceptibility genes for bronchial asthma (BA), the immunogenetic and other molecular mechanisms underlying disease risk and progression remain incompletely understood. This study aimed to investigate the association between two common…
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The Role of the Microbiome in the Development of an Autoimmune Reaction in Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA), a chronic inflammatory illness, have joint inflammation, increasing tissue damage, and severe disability, all of which negatively impact quality of life. While the precise mechanisms behind RA remain unknown, there is growing evidence that both the onset and…
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Genomic Analysis Revealed Hotspots of Genetic Adaptation and Risk of Disappearance in Brazilian Goat Populations
Background: The conservation of genetic resources is crucial for maintaining biological diversity and ensuring the sustainability of animal production. Characterizing regions of homozygosity (ROHs), heterozygosity-rich regions (HRRs), and levels of inbreeding is crucial for the management and…
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Circulating MicroRNAs and Clinical Parameters in Hypertrophic Cardiomyopathy: A Systematic Review and Correlation Meta-Analysis
Background: Hypertrophic cardiomyopathy (HCM) is genetically heterogeneous and characterized by left ventricular hypertrophy, myocardial fibrosis, and diverse clinical manifestations. Although circulating microRNAs (miRNAs) are promising biomarkers of pathological cardiac remodeling, the…
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Looking at Optic Nerve Sheath Meningiomas Through Genetics—From Clinic to Bench and Back Again
Optic nerve sheath meningiomas (ONSMs) occupy a unique intersection between neuro-oncology and genetics. Although most cases arise in middle-aged women as solitary, slow-growing tumors, pediatric onset, bilateral disease, or rapid progression frequently signal an underlying germline alteration…
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High-impact Genetic Variants in EGLN1, EPAS1, and Other Genes Identified in Mountaineers by Exome Sequencing
Background: Investigating the genetic basis of adaptation to environmental stresses, such as hypoxia, can enhance our understanding of human biology and resilience. High-altitude adaptation provides a valuable model for studying the genetic mechanisms of the hypoxic response. Indeed, most known…
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The Genetic Feasibility of Gonadal Development and Fertility in Polyodon-Acipenserid Interfamilial Hybrids: An Opinion on the Chromosomal Basis
Interfamilial hybridization between American paddlefish (Polyodon spathula) and Acipenserid (sturgeon) species produces viable hybrid offspring. However, the potential fertility of these hybrids is a critical issue for understanding sex determination mechanisms within Acipenseriformes, as well as…
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Molecular Characterization of the Epstein–Barr Virus in Malignant Tumors of Different Origins: An Emphasis on EBER Promoter Value for EBV Classification
Background: Epstein–Barr virus (EBV) is a well-known cause of infectious mononucleosisand it has also been linked to the development of various malignant tumors. EBV can be classified into two genotypes based on EBNA-2 and EBNA-3 polymorphisms, with further subclassification predominantly based on…
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Glut1 Acts in Corazonin-Producing Neurons to Regulate Glycogen Storage in Drosophila
Background: Metabolic homeostasis is regulated by numerous genes, whose dysregulation leads to metabolic diseases such as obesity and diabetes. Several genes important for lipid storage were identified in a buoyancy-based screen in Drosophila larvae, including Glucose transporter 1 (Glut1), which…
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Review of Potential Diagnostic and Therapeutic Developments in Systemic Lupus Erythematosus (SLE)
Systemic lupus erythematosus (SLE), a complex autoimmune disease, affects multiple tissues and organs, presenting substantial challenges for both diagnosis and treatment. Both innate and adaptive immune cells are involved in the intricate pathophysiology of SLE. The characteristics of SLE include…
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The Evaluation of Neurotrophic Receptor Tyrosine Kinase (NTRK) Alterations in Neuroblastomas
Background: Neuroblastoma (NB) is the most common extracranial solid tumor among pediatric cancers and accounts for approximately 15% of childhood cancer-related deaths. Neurotrophic receptor tyrosine kinases (NTRKs) are genes that play critical roles in the development and function of the nervous…
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Exploratory Study on Genetic Variants Related to Hydatidosis Susceptibility and Albendazole Pharmacogenetics in the Cusco Region in Peru
Background: Hydatidosis, caused by Echinococcus granulosus, is a neglected zoonotic disease with significant public health implications in endemic regions, such as in Cusco, Peru. Genetic factors influencing susceptibility to infection and responses to albendazole, the primary treatment, remain…
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Molecular Basis of Oxidative Stress-Induced Acute Kidney Injury, Kidney Fibrosis, Chronic Kidney Disease, and Clinical Significance of Targeting Reactive Oxygen Species-Regulated Pathways to Treat Kidney Disease
Kidney disease is a growing public health problem globally. Multiple or repeated acute injuries to the kidney due to chronic exposure to toxicants promote the development of chronic kidney disease (CKD), an irreversible disease for which there is no current treatment. Renal fibrosis, characterized…
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Genetic Analysis of Resistance to Puccinia triticina Erikss. In Triticum spelta L.
Background: Leaf rust caused by Puccinia triticina Erikss. is a widely distributed wheat (Triticum aestivum L.) disease. Using wild relatives, such as Triticum spelta L., as a source of desirable traits represents a good strategy for developing wheat varieties, as T. spelta L. has shown tolerance…
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Sperm DNA Fragmentation in Infertile Men With Varicocele: Clinical Epidemiology and Comparative Assessment of Microsurgical Varicocelectomy and Antioxidant Therapy
Background: Varicocele, a common condition affecting male fertility, has been linked to impaired semen quality and elevated sperm DNA fragmentation (SDF). This study aimed to evaluate the epidemiological prevalence of varicocele and SDF in infertile men and compare the effectiveness of…
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Optimal Algorithm for Gut Microbiota Differentiation: A Pilot Study of Adolescents with Different Body Weights
Background: The enterotype concept allows the differentiation of gut microbiota in relation to individual characteristics and is determined by the genetics and external stressors of the host. It was previously shown that not all clustering methods can accurately identify such enterotypes…
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Genomic Insights Into Developmental Language Disorders: Biomarkers and Their Interactions
Background: Developmental language disorders (DLDs) are common neurodevelopmental conditions, affecting approximately 7–10% of children, with significant impacts on communication, academic achievement, and social integration. While genetic factors are known contributors, the underlying genomic…
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Relationship Between Acinetobacter baumannii Pneumonia and Human CTLA4 Gene Polymorphism (rs231775) in Relation to IL-7 Serum Levels: A Study on Host–Pathogen Dynamics
Background: The relationship between genetic variations and susceptibility to infection provides insight into the pathogenesis of diseases caused by infections, illustrating host–pathogen interactions, informing preventive measures, and offering a novel therapeutic approach. Methods: This…
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Uterine Fibroids-Associated GWAS Loci and the Risk of Arterial Hypertension: A Pilot Study
Background: Uterine fibroids (UFs) are the most common benign tumors in women of reproductive age and are frequently associated with impaired fertility, reproductive dysfunction, and pregnancy complications. Arterial hypertension (AH) is another prevalent chronic condition in women, while…