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Oncology Reviews
Scopus
ISSN 1970-5557 · Frontiers Media S.A. · 506 artikel di indeks
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Artikel Jurnal
Gut microbiota–immunity cascade in hepatocellular carcinoma: mechanisms and therapeutic opportunities
Hepatocellular carcinoma (HCC) constitutes a major global health burden, with limited responsiveness to current immunotherapeutic regimens. Accumulating evidence underscores the gut microbiota as a crucial regulator of the gut–liver axis, modulating tumor initiation, immune evasion, and the…
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Artikel Jurnal
Sacituzumab tirumotecan (sac-TMT/MK-2870/SKB264): a novel antibody–drug conjugate in breast cancer
The discovery of antibody-drug conjugates (ADCs) has revolutionized the therapeutic landscape of oncology patients, especially those suffering from breast cancer. Following the approval of the first ADC for solid tumors in breast cancer, numerous additional ADCs have also been launched in the…
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Artikel Jurnal
Advances in epigenetics of gastric cancer
Gastric cancer (GC) persists as a leading cause of global cancer morbidity and mortality, with its pathogenesis intricately linked to epigenetic dysregulation. Emerging research specifies the novelty of these mechanisms—including DNA methylation, histone modifications, non-coding RNAs (ncRNAs), and…
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Artikel Jurnal
A new paradigm for retroperitoneal leiomyosarcoma: integrating transcriptomic subtyping and surgical risk stratification for AI-guided drug repurposing
Retroperitoneal leiomyosarcoma (RLMS) remains a major therapeutic challenge because of frequent postoperative recurrence and the limited benefit of current adjuvant therapies. The marked molecular heterogeneity of RLMS and its incompletely characterized oncogenic drivers have hindered the…
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How recreational therapies impact physiological and psychosocial outcomes in cancer patients: a review
Recreational Therapies (RecT) (e.g., art, dance, music, yoga, aromatherapy, Virtual Reality) are non-invasive interventions capable of enhancing the biopsychosocial wellbeing in patients, targeted to regenerate the existential dimensions of illness experience. While widely appreciated for their…
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Artikel Jurnal
HPV-positive cancers at uncommon sites: a narrative review
Human papillomavirus (HPV) usually infects the anogenital and the oropharyngeal areas. HPV may lead to cancer at these sites, most notably at the uterine cervix. Less frequently, vaginal, vulvar, anal and penile cancers may also arise. HPV may be also found, sometimes, in other cancers, such as…
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Artikel Jurnal
Evaluating the role of BMI in survival and complications in older esophageal squamous cell carcinoma following esophagectomy
BackgroundTo evaluate the impact of Body Mass Index (BMI) on survival and postoperative complications in older patients with esophageal squamous cell carcinoma (ESCC) following esophagectomy, we designed this study.Materials and methodsWe retrospectively analyzed 469 patients aged ≥70 years with…
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The CALLY index in cancer research: a comprehensive review
This review focuses on the CALLY index in cancer, exploring its theoretical foundations, epidemiological insights, diagnostic and prognostic applications, therapeutic implications, controversies, and future perspectives. The CALLY index, based on C - reactive protein, albumin, and lymphocyte…
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Immunosuppressive cell populations as potential drivers of extrinsic immune checkpoint inhibition resistance in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is an immunogenic cancer in which the use of Immune checkpoint inhibitors (ICIs) has provided clinical benefit. However, long-term therapeutic benefit is limited, as some do not respond initially while others develop resistance after treatment. Although…
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Artikel Jurnal
Primary pulmonary NUT carcinoma: pathological features, clinical diagnosis, treatment, and prognosis — An extended review
NUT carcinoma is a rare and aggressive lung tumor driven by NUTM1 gene rearrangements. It accounts for less than 1% of all lung cancers, with fewer than 100 cases reported worldwide. The disease is often misdiagnosed due to non-specific symptoms and histological overlap with other tumors. This…
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Artikel Jurnal
Exploring the immune enhancement effect of radiotherapy combined with NK cells on non-small cell lung cancer based on proteomics technology
BackgroundAlthough radiotherapy (RT) and natural killer (NK) cell-based therapy have shown promising potential in the treatment of non-small cell lung cancer (NSCLC), the therapeutic efficacy and safety of their combination remain to be fully elucidated. In this study, we evaluated the efficacy and…
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Risk factors for return to work in workers who experienced cancer: a systematic review with meta-analysis
BackgroundThe number of people who have experienced cancer is increasing, and by 2040 cases are expected to rise by 40%, with a high prevalence among working-age individuals. Many people who experienced cancer (pwEC) face reduced work ability due to health, personal, and occupational factors…
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Artikel Jurnal
Association of MMP-2 and hematological parameters with breast cancer metastasis: a cross-sectional study in Central Java, Indonesia
BackgroundBreast cancer metastasis remains a major contributor to morbidity and mortality, partly due to the disease’s marked biological heterogeneity. Identification of reliable biomarkers associated with metastatic progression is essential for improving risk stratification and clinical…
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Artikel Jurnal
Artificial intelligence–driven multimodal fusion for precision diagnosis and personalized management of breast cancer
Breast cancer is the most common malignancy among women worldwide, characterized by pronounced heterogeneity across molecular profiles, imaging phenotypes, and the tumor microenvironment. As precision oncology continues to advance, diagnostic strategies that rely predominantly on single-modality…
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Artikel Jurnal
Cardio-oncology in multidisciplinary synergy: addressing the rising burden of cancer therapy-related cardiovascular toxicity (CTR-CVT) in advancing oncology practices
IntroductionImprovements in cancer detection and the development of modern anticancer therapies have markedly increased survival rates among patients with malignancies, resulting in a rapidly expanding survivor population. Alongside these advances, cardiovascular complications related to cancer…
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Signaling pathway mechanisms in pancreatic ductal adenocarcinoma tumor microenvironment and emerging targeting strategies for improved prognosis
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by a dense desmoplastic stroma and a profoundly immunosuppressive tumor microenvironment (TME). The TME plays a major role in tumor progression, metastasis, and resistance to conventional therapies…
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Artikel Jurnal
Diagnostic utility of FAPI PET/CT in radioiodine-refractory thyroid cancer and TENIS syndrome: a systematic review
BackgroundFibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) has emerged as a promising molecular imaging modality with favorable lesion-to-background contrast across several malignancies. In radioiodine-refractory thyroid carcinoma (RAIR-TC)…
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Artikel Jurnal
Engineering probiotic consortia to improve chemotherapy tolerance and reduce toxicity in breast cancer patients: a new frontier in supportive precision oncology
Chemotherapy is a cornerstone of breast cancer treatment but is often limited by systemic toxicities, gastrointestinal mucositis, immunosuppression, and treatment interruptions, which compromise patient outcomes. Emerging evidence highlights the gut microbiome as a central mediator of chemotherapy…
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Adoptive T Cell therapy for cancer and autoimmune disease: current advances, challenges, and future directions
Adoptive T Cell Therapy (ACT) is a kind of immunotherapy that eliminates target cells by autologous T cells. Since the mechanism of adoptive immune was elucidated, ACT has been developed for more than half a century. As one of ACTs, chimeric antigen receptor (CAR)-T cell therapy produced remarkable…
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Artikel Jurnal
Analysis of the heterogeneity of the immune microenvironment of bone metastases and new strategies of nanotechnology intervention
Bone metastases constitute one of the most severe complications in patients with advanced malignancies. Conventional treatment approaches face significant limitations: surgical intervention carries a high risk of recurrence; radiotherapy and chemotherapy often cause myelosuppression; and…