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BMB Reports
Scopus
ISSN 1976-6696 · Korean Society for Biochemistry and Molecular Biology · 192 artikel di indeks
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Artikel Jurnal
miR-15b induced by platelet-derived growth factor signaling is required for vascular smooth muscle cell proliferation
The platelet-derived growth factor (PDGF) signaling pathway isessential for inducing a dedifferentiated state of vascular smoothmuscle cells (VSMCs). Activation of PDGF inhibits smoothmuscle cell (SMC)-specific gene expression and increases the rateof proliferation and migration, leading to…
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Inference of kinship coefficients from Korean SNP genotyping data
The determination of relatedness between individuals in afamily is crucial in analysis of common complex diseases. Wepresent a method to infer close inter-familial relationshipsbased on SNP genotyping data and provide the relationshipcoefficient of kinship in Korean families. We obtained…
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Identification of a novel circularized transcript of the AML1 gene
The AML1 gene is an essential transcription factor regulatingthe differentiation of hematopoietic stem cells into matureblood cells. Though at least 12 different alternatively splicedAML1 mRNAs are generated, three splice variants (AML1a,AML1b and AML1c) have been characterized. Here, using…
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PP2A function toward mitotic kinases and substrates during
To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex (CDK1:cyclin B) causes a remarkable change…
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Artikel Jurnal
Egr-1 regulates the transcription of the BRCA1 gene by etoposide
The breast cancer susceptibility gene BRCA1 encodes anuclear protein, which functions as a tumor suppressor and isinvolved in gene transcription and DNA repair processes.Many families with inherited breast and ovarian cancers havemutations in the BRCA1 gene. However, only a few studieshave reported…
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Somatic mutation patterns and compound response in cancers
The use of various cancer cell lines can recapitulate knowntumor-associated mutations and genetically define cancersubsets. This approach also enables comparative surveys ofassociations between cancer mutations and drug responses.Here, we analyzed the effects of ∼40,000 compounds oncancer cell…
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Artikel Jurnal
CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7
CpG-DNA has various immunomodulatory effects in dendriticcells, B cells, and macrophages. While induction of cytokinesby CpG-DNA has been well documented in macrophages, theexpression of costimulatory molecules in CpG-DNA treatedmacrophages has not yet been defined. Therefore, weinvestigated the…
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Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner
LRRK2 (leucine-rich repeat kinase 2) has been identified as agene corresponding to PARK8, an autosomal-dominant genefor familial Parkinson’s disease (PD). LRRK2 pathogenicspecificmutants induce neurotoxicity and shorten neurites. Toelucidate the mechanism underlying LRRK2 expression, weconstructed…
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Oxidative damage of DNA induced by the reaction of methylglyoxal with lysine in the presence of ferritin
Methylglyoxal (MG) is an endogenous metabolite which ispresent in increased concentrations in diabetics and reacts withamino acids to form advanced glycation end products. In thisstudy, we investigated whether ferritin enhances DNA cleavageby the reaction of MG with lysine. When plasmid DNA…
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Accelerating repaired basement membrane after bevacizumab treatment on alkali-burned mouse cornea
To understand the corneal regeneration induced by bevacizumab,we investigated the structure changes of stroma andbasement membrane regeneration. A Stick soaked in 0.5 NNaOH onto the mouse cornea and 2.5 mg/ml of bevacizumabwas delivered into an alkali-burned cornea (2 μl) by…
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Splicing and alternative splicing in rice and humans
Rice is a monocot gramineous crop, and one of the mostimportant staple foods. Rice is considered a model species formost gramineous crops. Extensive research on rice hasprovided critical guidance for other crops, such as maize andwheat. In recent years, climate change and exacerbated…
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Detection of rare point mutation via allele-specific amplification in emulsion PCR
It is essential to analyze rare mutations in many fields ofbiomedical research. However, the detection of rare mutationsis usually failed due to the interference of predominantwild-type DNA surrounded. Herein we describe a sensitiveand facile method of detecting rare point mutation on the basisof…
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Human extracellular superoxide dismutase (EC-SOD) expression in transgenic chicken
Extracellular superoxide dismutase (EC-SOD) is a metalloproteinand functions as an antioxidant enzyme. In this study,we used lentiviral vectors to generate transgenic chickens thatexpress the human EC-SOD gene. The recombinant lentiviruseswere injected into the subgerminal cavity of freshly…
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Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
Extracellular acidification occurs not only in pathologicalconditions such as inflammation and brain ischemia, but alsoin normal physiological conditions such as synaptic transmission.Acid-sensing ion channels (ASICs) can detect a broadrange of physiological pH changes during pathological…
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Acceleration of X-chromosome gene order evolution in the cattle lineage
The gene order on the X chromosome of eutherians isgenerally highly conserved, although an increase in the rate ofrearrangement has been reported in the rodent lineage.Conservation of the X chromosome is thought to be caused byselection related to maintenance of dosage compensation.However, we…
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Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle)
Although there have been many studies of native Koreancattle, Hanwoo, there have been no selective sweep studies inthese animals. This study was performed to characterizegenetic variation and identify selective signatures. We sequencedthe genomes of 12 cattle, and identified 15125420 SNPs,1768114…
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Artikel Jurnal
Modification and inactivation of Cu,Zn-superoxide dismutase by the lipid peroxidation product, acrolein
Acrolein is the most reactive aldehydic product of lipidperoxidation and is found to be elevated in the brain whenoxidative stress is high. The effects of acrolein on the structureand function of human Cu,Zn-superoxide dismutase (SOD) wereexamined. When Cu,Zn-SOD was incubated with acrolein…
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Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression
Phosphoinositide 3-kinases (PI3Ks) play key roles in synapticplasticity and cognitive functions in the brain. We recentlyfound that genetic deletion of PI3Kγ, the only known memberof class IB PI3Ks, results in impaired N-methyl-D-aspartatereceptor-dependent long-term depression (NMDAR-LTD) inthe…
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Artikel Jurnal
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9
The expression of matrix metalloproteinases (MMPs) produced bycancer cells has been associated with the high potential ofmetastasis in several human carcinomas, including breast cancer.Several pieces of evidence demonstrate that protein tyrosinephosphatases (PTP) have functions that promote cell…
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Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia
Inflammatory conditions mediated by activated microglia leadto chronic neuro-degenerative diseases such as Alzheimer’s,Parkinson’s, and Huntington’s diseases. This study wasconducted to determine the effect of floridoside isolated frommarine red algae Laurencia undulata on LPS (100 ng/ml)activated…