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Clinical and Experimental Otorhinolaryngology
Scopus
ISSN 1976-8710 · Korean Society of Otorhinolaryngology-Head and Neck Surgery · 979 artikel di indeks
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Continuous Positive Airway Pressure Therapy Alters Monocyte Activation and Immune Phenotype in Obstructive Sleep Apnea in Relation to Hypoxic Burden
Objectives. Obstructive sleep apnea (OSA) is associated with chronic intermittent hypoxia and systemic inflammation, both of which contribute to vascular and metabolic complications. Monocytes, as key immune cells of innate immunity, have been implicated in this inflammatory state. However, the…
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Prognostic Comparison of Long-Term Outcomes and Nodal Recurrence for Persistent and Recurrent Differentiated Thyroid Cancer
Objectives. Differentiated thyroid cancer (DTC) has a favorable prognosis. However, indeterminate lymph nodes (LNs) are common, making it challenging to distinguish recurrent from persistent DTC. Previous studies have not specifically compared the prognosis between recurrent and persistent DTC…
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Preoperative Hearing Aids Improve Outcomes of Cochlear Implantation
Objectives. We aimed to investigate the effects of preoperative auditory rehabilitation using hearing aids in patients with prolonged hearing deprivation. Methods. We retrospectively enrolled 204 patients who underwent cochlear implantation surgery at age >60 years using a single university…
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The Efficacy of Intranasal Insulin in the Treatment of Post-Viral Persistent Olfactory Dysfunction: A Systematic Review
Objectives. This study aimed to evaluate the therapeutic efficacy of intranasal insulin in treating persistent and refractory olfactory dysfunction following viral infections. Methods. A comprehensive literature search was performed across PubMed, Scopus, Embase, Web of Science, Google Scholar, and…
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The Impact of Pcdh15 Deficiency on Cellular Energy Metabolism and Oxidative Stress, and Its Role and Mechanism in Hearing Loss
Objectives. This study aimed to explore the role of the Pcdh15 gene in hearing maintenance and to examine the effects of its deficiency on cochlear structure, cochlear function, and hearing loss in mice. Methods. CRISPR/Cas9 technology was used to generate Pcdh15 knockout (KO) mice. Auditory…
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Physiological Measures of Reduced Listening Effort in Active Noise Canceling: Evidence From a Low-β Functional Network in an Event-Related Potential Study
Objectives. In this study, we investigated the neurophysiological impact of active noise cancellation (ANC) technology on auditory–cognitive processing and listening effort, addressing a critical gap in the literature on ANC efficacy. Although ANC is increasingly adopted in contemporary devices…
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Subjective and Objective Assessments of Olfactory Function in Patients Taking Anti-obesity Medications
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Harnessing Machine Learning for Personalized Care of Patients With Idiopathic Sudden Sensorineural Hearing Loss: A Multicenter Cohort Study
Objectives. Idiopathic sudden sensorineural hearing loss (ISSNHL) is a significant cause of hearing loss. Intratympanic steroid injection (ITSI) is commonly used as an initial or salvage treatment; however, the lack of a standardized treatment protocol has resulted in variability in clinical…
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Guideline for the Management of Obesity in Adult Patients With Obstructive Sleep Apnea
Objectives. Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that is strongly influenced by obesity, the most important modifiable risk factor. Effective weight management is therefore essential for optimal OSA care. This guideline provides updated, evidence-based…
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Efficacy of Montelukast–Antihistamine Combination Therapy Versus Antihistamine Monotherapy in Allergic Rhinitis: A Systematic Review and Meta-Analysis
Objectives. Allergic rhinitis (AR) can substantially compromise daily functioning and well-being, and many patients require more than a single agent to obtain satisfactory symptom control. This study examined whether adding montelukast to antihistamine could manage AR symptoms and quality-of-life…
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Clinical Impact of Rapid Recurrence in Oral Tongue Squamous Cell Carcinoma and a Nomogram for Early Identification of High-Risk Patients
Objectives. This study investigated the effects of clinicopathological variables on rapid recurrence (defined as recurrence within 3 months) in oral tongue squamous cell carcinoma (OTSCC) and developed prediction models using multiple data combinations. Methods. A total of 944 patients with OTSCC…
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Human Papillomavirus (HPV)-Infected Epithelial Cells and FBLN1-Positive Fibroreticular Cells Govern the Immunogenic Tumor Microenvironment in HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Objectives. Oropharyngeal squamous cell carcinoma (OPSCC) exhibits distinct clinical behaviors according to human papillomavirus (HPV) status. HPV-associated OPSCC is typically associated with a more favorable prognosis and improved response to therapy than non-HPV–associated OPSCC; however, the…
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Airway Anatomy and Surgical Management in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by recurrent collapse of a structurally vulnerable upper airway during sleep. Airway caliber and stability are influenced by multiple anatomical structures, including the nasal cavity, soft palate, lateral pharyngeal…
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Single-Cell RNA Sequencing Reveals the Heterogeneity and Microenvironment of Temporal Bone Squamous Cell Carcinoma
Objectives. Temporal bone squamous cell carcinoma (TBSCC) is the most common subtype of temporal bone malignancy. However, its low incidence, high misdiagnosis rate, and the difficulty of conducting large-scale studies and clinical trials have limited researchers’ understanding of its occurrence…
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Effects of Neonatal Deafness on Central Tonotopic Organization in Rats: an Electrophysiological Study
Objectives Spatial mapping of sound frequencies along the auditory pathway is refined through sound-evoked activity during early development. However, how neonatal auditory deprivation alters this organization remains unclear. This study examined frequency-specific spatial representations in the…
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Impact of Margin-to-Depth of Invasion Ratio on Oncologic Outcomes in Locally Advanced Oral Cancer Treated With Surgery and Chemoradiotherapy
Objectives This study aimed to evaluate the prognostic value of the margin-to-depth of invasion ratio (MDR) in patients with locally advanced oral squamous cell carcinoma (LAOSCC) who underwent curative surgery followed by adjuvant concurrent chemoradiotherapy (CCRT). Methods We analyzed 422…
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A Marked Decrease in Speech Intelligibility Is No Longer a Major Characteristic of Vestibular Schwannoma in the Current Era
Objectives Speech intelligibility is reported to be markedly decreased in patients with vestibular schwannoma (VS); however, the relationship between speech intelligibility and hearing level remains poorly characterized. Methods We created scatter plots of pure-tone audiometry (PTA) thresholds and…