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Viruses
Scopus
ISSN 1999-4915 · MDPI AG · 17.743 artikel di indeks
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Three Staphylococcus Bacteriophages Isolated from Swine Farm Environment in Quebec, Canada, Infecting S. chromogenes
Exudative epidermitis (EE), caused by Staphylococcus hyicus, represents an issue for swine production, particularly due to antimicrobial resistance. In this project, we isolated bacteriophages using S. hyicus as host and studied them as a potential alternative to antibiotic treatment in Quebec…
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A Prediction Model for Uncoating Receptor Usage in Human Enteroviruses Based on Amino Acid Sequences and a Naive Bayes Algorithm
This study constructed a bioinformatics prediction algorithm for human enterovirus uncoating receptors based on amino acid sequences and physicochemical properties. Based on the availability of uncoating receptor information and three-dimensional (3D) structural data, human enterovirus serotypes…
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Metavirome Detection and Analysis of Viruses Present in Diseased Pumpkin in Shandong, China
Viral diseases pose a serious threat to pumpkin cultivation, which is an important cucurbitaceous vegetable crop. Recently, multi-virus mixed infections in plants have been continuously detected and reported. However, studies on mixed virus infections in pumpkins are limited. Through metavirome and…
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HaCaT Keratinocytes: A Differentiation-Competent Platform for Episomal Replication of HPV Type 11
Few differentiation-competent models exist to study early intra-nuclear processes of human papillomavirus (HPV) in keratinocytes. Early HPV DNA replication is usually studied by transfecting transformed or tumor-derived cell lines (C33A, HEK293/HEK293T, CIN612). While these lines support episome…
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Long Non-Coding RNAs Can Govern the Antiviral Immune Response Through Interferon-Mediated Mechanisms in Respiratory Tract
Many long non-coding RNAs (lncRNAs) are able to control interferon-dependent innate immune responses and the susceptibility to influenza infection. These lncRNAs are primarily regulated through the RIG-I/IFN-β/IFNAR1 pathway and can be considered as interferon-stimulated genes with either antiviral…
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Oral Immunization with the C488A Live-Attenuated Mutant of Coxsackievirus B4E2 (CVB4E2) Induces Potent Immune Response and Protects Balb/c Mice Against Lethal Infection
Background/Objectives: Coxsackievirus B4 (CVB4), a member of the Enterovirus genus and the Picornaviridae family, is a significant pathogen causing several human diseases such as pancreatitis, myocarditis, cardiomyopathy and type 1 diabetes. Despite its clinical impact, no vaccines or specific…
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ASFV MGF110-7L Inhibits eIF4G1 Expression via Endoplasmic Reticulum Stress to Block Host Translation
African swine fever virus (ASFV) is a highly contagious and lethal double-stranded DNA virus that relies on host cellular translation machinery for replication and immune evasion. The multigene family 110 (MGF110) contains several members with incompletely defined functions. Here, the role of…
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Co-Infection and Phylogenetic Evolution of CIAV in Marek’s Disease Tumour-Bearing Flocks in Central China
The avian immunosuppressive and neoplastic diseases are great threats to the poultry industry, causing huge economic losses worldwide. Most recently, the emerging hypervirulent variants of Marek’s disease virus (HV-MDV), partially co-infected with avian leukosis virus (ALV) and/or…
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Unravelling the Evolutionary Complexity of Orf Virus: A Global and Multi-Host Perspective
Orf virus (ORFV), a member of the Parapoxvirus genus, is commonly associated with a highly infectious skin disease primarily affecting sheep and goats, with a reported zoonotic potential. Initially identified in the 18th century, ORFV has been sporadically reported in other species, including…
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Interactions of Dengue Virus NS5 and NS3 with the 3′ End of Its Negative-Strand RNA
Dengue virus is an important human pathogen that infects over 400 million people each year. Despite its global health significance, several essential aspects of the viral replication mechanism remain poorly understood. Flaviviruses carry out asymmetric viral RNA synthesis, wherein positive-strand…
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CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs
With the advancements in instrumentation, image processing algorithms, and computational capabilities, single-particle cryo-electron microscopy (cryo-EM) has achieved atomic resolution in determining the 3D structures of viruses. The virus structures play a crucial role in studying their biological…
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Importin Alpha Is Implicated in the Nuclear Import of Novel Duck Reovirus Protein p18
Novel duck reovirus encodes a new nucleus-localized protein, p18. We aimed to investigate whether the nuclear entry of p18 is dependent on viral replication, identify the cellular proteins that interact with p18, and determine the transporters involved in the nuclear import. The subcellular…
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Parvovirus B19 in Children: Clinical Spectrum, Viral Load Patterns, and Atypical Cutaneous Presentations in the Post-Pandemic Outbreak
Background: Human parvovirus B19 causes a broad spectrum of clinical manifestations, ranging from the classic “fifth disease” to severe presentations. Clinical presentation varies considerably across age groups. In 2023–2024, a notable increase in parvovirus B19 cases was reported across Europe…
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Concentration- and Time-Dependent Virucidal Responses of Major Transboundary Animal Disease Viruses to Disinfectants
Transboundary animal diseases (TADs) pose persistent threats to global livestock production, and chemical disinfection remains a critical component of biosecurity. However, virucidal efficacy is commonly assessed using single-condition endpoints, limiting comparative interpretation across…
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Shellfish as a Potential Source of Hepatitis E Virus: Epidemiological Evidence, Biological Plausibility, and Research Gaps
Hepatitis E virus (HEV) is an important cause of acute and chronic hepatitis worldwide, transmitted primarily through waterborne exposure and zoonotic foodborne pathways. In recent years, shellfish have attracted growing attention as a potential vehicle for HEV transmission. This interest is driven…
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CRISPR-Based Detection of Viral Hemorrhagic Fevers at the Point of Care
Viral hemorrhagic fevers (VHFs) are highly lethal diseases that often present non-specific, influenza-like symptoms in their early stages, making clinical recognition and differentiation from other febrile illnesses difficult. This overlap underscores the critical need for diagnostic tests that are…
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Seroprevalence and Epidemiological Characteristics of Severe Fever with Thrombocytopenia Syndrome in Patients with Chronic Diseases in Korea
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease with a high mortality rate. While research has focused on high-risk rural populations and healthy individuals in endemic regions, such as Jeju Island, data on patients with underlying chronic diseases remain limited. This…
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Isolation and Genomic Characterization of Two Lytic Cutibacterium acnes Phages Defines Two Novel Pahexavirus Species
Bacteriophages are promising antibacterial agents for managing acne vulgaris caused by Cutibacterium acnes, particularly given increasing antibiotic resistance. Here, we isolated and characterized two lytic Cutibacterium phages, NS-ph1 and NS-ph2, from acne lesions. Both bacteriophages exhibited a…
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Social Determinants and Outbreak Dynamics of the 2025 Measles Epidemic in Mexico: A Nationwide Analysis of Linked Surveillance Data
Measles resurgence threatens elimination achievements in the Americas. We conducted a nationwide analysis of Mexico’s 2025–2026 measles outbreak, integrating individual-level surveillance data from the Special Surveillance System for Febrile Exanthematous Diseases with municipal-level social…
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Human Prion Disease: Pathogenesis, Diagnosis and Public Health
Background: Prion diseases represent a group of rare, progressive, and invariably fatal neurodegenerative disorders. Their hallmark is the infectious nature of the misfolded prion protein (PrP^Sc), which propagates by inducing conformational changes in the physiological form (PrP^C). Despite…
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