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Clinical and Translational Medicine
Scopus
ISSN 2001-1326 · Wiley · 2.624 artikel di indeks
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Artikel Jurnal
Quantum medicine: A quantum–mechanical framework for redox biology, disease and precision medicine
Abstract Background Key biological processes underlying health and disease‐including electron transfer, redox regulation, and radical‐mediated signaling‐are fundamentally governed by quantum‐mechanical principles. These processes are central to mitochondrial function, metabolism, and cellular…
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Artikel Jurnal
Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours
Abstract Background Adult ovarian granulosa cell tumours (GCT) are the most common subtype of ovarian sex cord‐stromal tumours. Forkhead transcription factor FOXL2 is required for development and function of normal granulosa cells, including proliferation and ovarian hormone synthesis. A single…
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Artikel Jurnal
MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement
Abstract Background Thrombosis is a common complication in paroxysmal nocturnal haemoglobinuria (PNH) patients, but primary prevention remains controversial. Identifying high‐risk individuals could enable risk‐stratified prophylactic anticoagulation strategies. Methods We analyzed clinical data…
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Artikel Jurnal
Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma
Abstract Background DDB1 and CUL4‐associated factor 7 (DCAF7) is a WD‐repeat adaptor that recruits substrates to the CUL4DDB1 ubiquitinligase complex, but its pan‐cancer relevance and mechanistic contribution to tumor progression remain unclear. Methods Multi‐omics datasets (genomic…
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Artikel Jurnal
Feedback regulation between histone H3 lysine 18 lactylation and TROP2‐mediated glycolysis drives metastatic progression of colorectal cancer
Abstract Background TROP2, a critical cell surface oncogenic signal transducer, is increasingly linked to refractory metastatic colorectal cancer (CRC) and other solid tumours. Robust lactate accumulation within metastatic niches correlates with pathological metastatic progression. Anti‐TROP2…
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Artikel Jurnal
Multi‐omics analysis identifies PUS7 as an immune modulator driving NETs‐mediated macrophage polarization in pancreatic cancer
Abstract Pseudouridine synthases (PUS) have been implicated in various cancers, yet their roles in pancreatic cancer immunity remain unclear. Through integrative multi‐omics analyses combining genomics, transcriptomics, and clinical datasets, we evaluated associations between PUS family genes and…
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Artikel Jurnal
Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model
Abstract Background DFNB16, the second most common genetic cause of hearing loss, is caused by mutations of the STRC gene encoding stereocilin, a protein essential for the effective functioning of outer hair cells (OHCs) as cochlear amplifiers. Strc−/− mice, which lack stereocilin, display severe…
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Artikel Jurnal
Decoding innate lymphoid cell heterogeneity and plasticity in colorectal cancer
Abstract Background In colorectal cancer (CRC), innate lymphoid cells (ILCs) play a vital role in preserving and modulating immune homeostasis within the intestinal environment. However, the origins and diverse functions of ILCs in CRC remain poorly understood, making it difficult to clarify how…
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Artikel Jurnal
Roll with the punches: Fibroblast growth factor 10 alleviates pyroptosis of alveolar epithelial cells in different immune niches
Abstract Background Acute respiratory distress syndrome (ARDS) is a life‐threatening condition characterized by high mortality with no specific treatments. Fibroblast growth factor 10 (FGF10) is recognized for its tissue repair and anti‐inflammatory roles in injured lungs; however, its clinical…
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Artikel Jurnal
Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer
Abstract Background O‐linked N‐acetylglucosamine protein modification (O‐GlcNAcylation) is a dynamic, nutrient‐sensitive post‐translational modification frequently upregulated in cancers. Autophagy, a lysosome‐dependent recycling pathway, plays a context‐dependent dual role in tumorigenesis and…
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Artikel Jurnal
Melatonin‐engineered MSCs‐exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival
Abstract Background This study investigates the impact of sleep restriction (SR) on flap viability and its underlying mechanisms. It reveals that SR triggers clock rhythmic ferroptosis, which leads to impaired skin barrier function and increased flap necrosis. Methods A retrospective analysis of…
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Artikel Jurnal
Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis
Abstract Background Elevated lactate is associated with vascular endothelial dysfunction, a factor that can contribute to organ failure in sepsis. However, the specific mechanisms involved have yet to be fully elucidated. Here, we investigated the role of enolase 1 (ENO1) lactylation in modulating…
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Artikel Jurnal
Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers
Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC), contributing to tumour progression, metastatic dissemination and immune evasion. Hypoxia‐induced angiogenic signalling…
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Artikel Jurnal
FABP4‐mediated lipid droplet accumulation drives epithelial–mesenchymal transition and aggravates alveolar epithelial barrier disruption
Abstract Background Acute respiratory distress syndrome (ARDS) frequently develops after cardiopulmonary bypass (CPB), with lung ischemia/reperfusion injury (LIRI) as a major contributing factor. However, the role of fatty acid‐binding protein 4 (FABP4) in the pathogenesis of CPB‐associated ARDS…
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Artikel Jurnal
Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer
Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage non‐small‐cell lung cancer (NSCLC), but it has not consistently yielded durable responses. Biomarkers for the prediction of efficacy are warranted…
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Artikel Jurnal
Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma
Abstract Background BRD7 has been confirmed to be lowly expressed in nasopharyngeal carcinoma (NPC) tissues and exerts tumour suppressive roles. However, the molecular mechanism of the downregulation of BRD7 expression and whether the strategy of activating BRD7 expression plays anti‐tumour effects…
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