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International Journal of Fertility and Sterility
Scopus
ISSN 2008-076X · Royan Institute (ACECR), Tehran · 994 articles in the index
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Melatonin Improves Sperm Quality in Asthenozoospermic Men by Preserving Acrosome Integrity, Reducing Inflammation, and Regulating Apoptosis-Related Genes and Proteins during Freeze-Thawing
Background: Sperm freeze-thaw is a crucial technique in assisted reproductive technologies (ART), but it inducesoxidative stress in sperm. Melatonin, a powerful antioxidant, reduces oxidative stress by penetrating mitochondria andneutralising free radicals. However, its protective role in the sperm…
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How Many Children Do Iranian Youth Intend to Have?
The sharp decline in fertility in Iran represents one of the country’s most pressing demographic challenges. This trendhas led policymakers to promote childbearing to mitigate further population aging and structural imbalance. Thisstudy uses data from the 2017-2018 Iranian National Marriage and…
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Gene Expression Dynamics and Network Analysis Reveal Key Molecular Pathways in Spermatogenic Progression from Spermatogonial Stem Cells to Round Spermatids
Background: Spermatogenesis is a tightly regulated process that involves an orchestrated transcriptional and translationalevent across the seminiferous epithelium. While individual regulators of this process have been studied, thenetwork-level dynamics underlying the transition from spermatogonial…
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Innovative Xenotransplantation of Reconstructed Human Artificial Ovary Using 3D-Printed Scaffolds and Umbilical Cord Mesenchymal Stem Cells
Background: The primary objective of this study was to develop an artificial ovary made of polylactic acid (PLA)material, which could potentially be used for fertility preservation. This scaffold was used to carry umbilical cordmesenchymal stem cells (UCMSCs) for xenotransplantation to study…
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Obstetric Complications in Pregnant Women with and without Endometriosis: A Comparative Cohort Study
Background: Since the complications associated with endometriosis during pregnancy are rare, there is not enoughevidence to indicate that this disease has major detrimental effects on pregnancy outcome. Therefore, the present studywas conducted with the aim of investigating pregnancy complications…
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Insights into The Outcomes of Artificial Oocyte Activation: A Retrospecive Analysis of 1,300 Couples Undergoing Intracytoplasmic Sperm Injection
Background: Oocyte activation deficiency remains a significant obstacle in assisted reproductive technologies. Intracytoplasmicsperm injection combined with artificial oocyte activation (ICSI-AOA) has been introduced as a promisingstrategy to enhance fertilization efficiency and clinical outcomes…
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Phenotype-Specific Association of LHCGR rs13405728 Polymorphism with Anovulatory Infertility in Malay Women with Polycystic Ovary Syndrome: A Case-Control Study
Background: Polycystic ovary syndrome (PCOS) is a multifactorial, polygenic endocrinopathy with an incompletelyunderstood aetiology that accounts for approximately 80% of female anovulatory infertility. Both genetic and environmentalfactors contribute significantly to its pathogenesis. This study…
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Modeling Diagnosis and Clinical Outcomes in Infertility Couples Considering Multiple Factors: A Retrospective Study
Background: Infertility arises from diverse etiologies, with polycystic ovarian syndrome (PCOS) being a leadingcause among women, while male factors account for approximately 50% of cases. Selecting the most appropriate assistedreproductive technology (ART) for each couple is crucial. This study…
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Effect of Intracytoplasmic Sperm Injection Alone versus ICSI and Preimplantation Genetic Screening on Pregnancy Outcomes of Patients with A History of Gestational Trophoblastic Disease: A Retrospective Study
Background: Gestational trophoblastic disease (GTD) is characterized genetically by an excess paternal genome and maternalchromosome loss. Intracytoplasmic sperm injection (ICSI) and ICSI with preimplantation genetic screening (PGS)enhance the selection of viable embryos by ensuring that only those…
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Role of Epigenetic Modifications in The Aberrant Expression of The FOXP3 Gene in Endometriosis: A Case-Control Study
Background: Various studies have reported aberrant function of the immune system in endometriosis. This highlyprevalent disease can initiate and progress by numerous genetic and epigenetic alterations that affect immune systemfunctions. Regulatory T cells (Treg) play an important role in…
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Fertility Preservation in Female Patients with Cancer. Part III: Royan Human Ovarian Tissue Bank Guideline for Prepubertal Girls and Women, A Review
Advances in early cancer diagnosis and treatment have significantly improved survival rates. However, as awarenessgrows about the adverse effects of cytotoxic therapies on ovarian function and fertility, an increasing number of patientsare seeking fertility preservation before undergoing…
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Moderate Intensity Exercise Training in Combination with L-Carnitine Ameliorates The Varicocele-Suppressed Self-Renewal; Implication on Gdnf/C-ret/Gfrɑ1 Complex Signaling in Rats
Background: For the first time, this study aimed to investigate the potential protective effects of L-carnitineand moderate-intensity exercise training (MIET), both individually and in combination, against varicocele(VCL)-induced impairment of spermatogonial stem cell (SSC) self-renewal.Materials…
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The Effect of Human Papillomavirus on Sperm Parameters: An Umbrella Review and Meta-analysis
Background: Human papillomavirus (HPV) is a prevalent sexually transmitted virus hypothesised to contribute tounexplained male infertility that potentially affects sperm quality. The current research looks at the impact of HPVinfections on sperm quality.Materials and Methods: Web of Science…
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Combined Effects of 7,12-dimethylbenz[a]anthracene (DMBA) with Cobalt, Cadmium, or Zinc on Fertility in Rats
Background: Infertility remains a multifactorial disorder influenced by both genetic and environmental factors, yetthe molecular interplay between these two dimensions is poorly understood. The Brca1 gene, classically known forits tumor-suppressive role in mammary tissue, also plays a crucial role…
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Association of Antiphospholipid Antibodies with Pregnancy Outcomes in Women with Recurrent Implantation Failure: A Retrospective Cohort Study
Background: Antiphospholipid antibodies (aPL) may contribute to recurrent implantation failure (RIF) in womenundergoing in vitro fertilization (IVF). These antibodies may impair endometrial receptivity and placentation, thoughevidence remains contradictory due to incomplete aPL data…
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The Effectiveness of Pelvic Floor Physiotherapy on Endometrial Thickness during Embryo Transfer in Infertile Women: A Systematic Review and Meta-analysis
Background: Embryo transfer is a complex process that often fails due to poor endometrial growth. Pelvic floorphysiotherapy improves endometrial thickness by enhancing pelvic blood circulation and stimulating uterine musclewith varied frequency flows, consequently boosting embryo implantation and…
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The Effects of Alpha-Lipoic Acid Supplement on Sperm Parameters and DNA Fragmentation in Couples with Recurrent Pregnancy Loss: A Randomized Controlled Trial
Background: Previous studies have shown that the level of oxidative stress in individuals with recurrent pregnancyloss (RPL) is significantly higher than in fertile individuals. Alpha-lipoic acid (ALA) has been considered anantioxidant that can improve male fertility. This study aimed to…
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Protocol for Evaluating The Effect of Pelvic Physiotherapy on Uterine Blood Flow: A Single-Center, Two-Arm, Parallel, Randomized, Clinical Trial
Background: Repeated implantation failure (RIF) is a major challenge in in vitro fertilization (IVF). Insufficientuterine blood flow and reduced endometrial thickness are important factors contributing to implantation failure. Pelvicphysiotherapy, including electrotherapy, manual therapy, and…
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The Effect of Intramuscular Human Chorionic Gonadotropin on Endometrial Preparation in Frozen-Thawed Embryo Transfer: A Randomized Clinical Trial
Background: Experimental evidence suggests that the human endometrium expresses receptors for human chorionic gonadotropin (hCG), and activation of these receptors may enhance embryo implantation. Numerous studies have explored the effects of intrauterine hCG injection on embryo transfer (ET)…
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Intracytoplasmic Sperm Injection Clinical Outcomes: A Non-Inferiority Comparison of The Novel Felix™ Electrophoretic System and Conventional Density Gradient Centrifugation for Sperm Selection, A Prospective Clinical Trial
Background: In intracytoplasmic sperm injection (ICSI), sperm selection has traditionally relied on motility and morphology,often overlooking DNA integrity. This study evaluates the Felix™ Electrophoretic System, which isolatessperm based on membrane surface electric charge, by assessing its…