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Iranian Journal of Microbiology
Scopus
ISSN 2008-3289 · Tehran University of Medical Sciences · 1.247 artikel di indeks
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Artikel Jurnal
Incidence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from women with urinary tract infections in Jordan
Background and Objectives: Urinary tract infections are one of the world's major health problems. In addition, clinical disorders may result from the presence of bacteria or fungi in urine. The aim of this study was to isolate Escherichia coli (E. coli) strains from midstream urine samples, and to…
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Artikel Jurnal
Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles
Following the worldwide spread of Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), there is a vital requirement for safe and effective vaccines against Coronavirus disease 2019 (COVID-19). Therefore, several vaccine-candidate platforms have been designed, tested, and developed. Based…
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Artikel Jurnal
In vitro investigations of coelomic fluid of Eisenia fetida: protein analysis, antioxidant activities and antibacterial effects on diabetic wounds' bacteria
Background and Objectives: Diabetes is a metabolic disorder characterized by elevated glucose levels, leading to complications such as infections and impaired wound healing. Diabetic wounds are prone to bacterial infections, with common pathogens including Staphylococcus, Escherichia coli, Bacillus…
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Artikel Jurnal
Comparative analysis of gut microbiota composition in the fecal samples from type 2 diabetes mellitus patients and healthy individuals: a case control study
Background and Objectives: Insulin resistance and elevated blood glucose levels are the hallmarks of Type 2 Diabetes Mellitus (T2DM), a chronic metabolic condition. Emerging research suggests that gut microbiota may play a causal role in T2DM. This study compares T2DM patients' gut microbiota to…
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Artikel Jurnal
Effect of supplementation on biofilms and antibiotic efficacy against Pseudomonas aeruginosa
Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is one of the leading causes of nosocomial infections, particularly in vulnerable patients. However, treating these infections is challenging due to its various antibiotic resistance mechanisms and biofilm formation ability. As…
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Artikel Jurnal
Tight junctions expression is affected by active, inactive, and derivatives of Akkermansia muciniphila
Background and Objectives: Tight junctions (TJs) in the gastrointestinal tract are comprised of various junctional proteins including Occludin and Zonula Occludens (ZO-1) that have a critical role in epithelial barrier function. Gut microbiota and their derived metabolites can maintain and regulate…
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Artikel Jurnal
Human milk as a source of next-generation probiotics: quantifying Akkermansia muciniphila and microbial contamination risks in donor milk
Background and Objectives: Human milk provides nutrients, prebiotics, and probiotics that support infants’ physical and mental growth. Human milk microbiota, as a potential source of probiotics and an indicator of the safety of donor milk, is of great importance. Akkermansia muciniphila, a core…
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Artikel Jurnal
Core genome expansion in Brevibacterium across marine provinces reveals genomic footprint for long-term marine adaptation
Background and Objectives: Actinobacteria are ubiquitous across diverse environmental niches. Brevibacterium strains within this phylum are widely distributed in both marine and terrestrial ecosystems worldwide. Marine environments are defined by distinct physicochemical properties—high salinity…
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Artikel Jurnal
Preliminary investigation of changes in pathogen presence in the vaginal microbiome in association with age
Background and Objectives: The vaginal microbiome represents a dynamic ecosystem that undergoes significant transformations throughout a woman's lifespan, influenced by hormonal fluctuations and physiological changes. Interpreting pathogen distribution and developing suitable therapeutic care…
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Artikel Jurnal
Estimation of second line anti-tubercular drug susceptibility to Mycobacterium tuberculosis in clinical isolates
Background and Objectives: Tuberculosis (TB) is an infectious disease that is among the most common in the world and is a leading cause of high mortality and morbidity. In India, there is very limited data on second line drug susceptibility testing. The aim of the study was to find out the…
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Artikel Jurnal
Multiplex PCR for lower respiratory tract infection diagnosis in ICU and non-ICU settings: enhancing diagnostic stewardship in Indian tertiary care
Background and Objectives: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in both ICU and non-ICU patients. Timely identification of causative pathogens and antimicrobial resistance (AMR) genes is critical for optimizing therapy. This study evaluated the…
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Artikel Jurnal
Investigation of the effect of dimethyl sulfoxide on growth and biofilm formation of Pseudomonas aeruginosa
Background and Objectives: The antimicrobial resistance of Pseudomonas aeruginosa bacteria limits the spectrum of effective antibiotics. Considerable focus has been placed on the identification of more contemporary and cost-effective antimicrobial drugs. In this study, the antibacterial properties…
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Artikel Jurnal
The etiology of acute infectious febrile illnesses at a tertiary care hospital: an experience from a hilly region of Uttarakhand
Background and Objectives: The differential diagnosis of acute febrile illness (AFI) is influenced by the regional distribution of prevalent diseases. Hence, in our hospital-based data analysis, we evaluated the AFI cases presented to our center to raise awareness among clinicians and…
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Artikel Jurnal
Prevalence of exoA, cepA, plcH, lasB, and algD virulence genes in clinical isolates of Pseudomonas aeruginosa from hospitals in Yasuj and Shiraz, Iran
Background and Objectives: Pseudomonas aeruginosa, an opportunistic Gram-negative bacterium, is ubiquitous and represents one of the most challenging multidrug-resistant pathogens today. This multicenter study aimed to evaluate antibiotic resistance patterns, detect the cepA antibiotic resistance…
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Artikel Jurnal
Evaluation of Helicobacter pylori-derived outer membrane vesicles on the expression of inflammatory cytokines
Background and Objectives: Helicobacter pylori infection has been increasingly linked to extra-gastric diseases. Outer membrane vesicles are a key virulence factor of H. pylori. This study investigates the influence of H. pylori-derived outer membrane vesicles on inflammatory marker expression in…
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Artikel Jurnal
The occurrences of E. coli strains with multi-drug resistance profiles and virulence genes from poultry slaughterhouse waste in Abidjan (côte d’ivoire)
Background and Objectives: Poultry production generates huge quantities of waste, mainly from slaughterhouses, which can be major reservoirs of pathogenic microorganisms. Escherichia coli is of particular concern due to its ability to acquire antibiotic resistance and virulence factors. This study…
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Artikel Jurnal
Yeast-mediated display: probing Helicobacter pylori HopQ and CEACAM1 interaction
Background and Objectives: Helicobacter pylori (H. pylori), as a Gram-negative pathogen plays a key role in causing gastritis, peptic ulcer disease, and gastric malignancies. The bacterial adhesin HopQ binds human CEACAM1, promoting adherence and CagA oncoprotein translocation. This study aimed to…
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Artikel Jurnal
Identification of plasmid encoded qepA efflux pump gene in Citrobacter freundii isolates from a renowned hospital, Bangladesh
Background and Objectives: The emergence of plasmid-mediated resistance to quinolones is a growing global threat that complicates the control of multidrug-resistance (MDR) in Enterobacteriaceae. This study was conducted to determine the frequency of the qepA gene and its association with antibiotic…
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Artikel Jurnal
Molecular identification and diagnostic challenges of Kodamaea ohmeri fungemia in a neonate - first report from Pakistan
Background and Objectives: Kodamaea ohmeri is an uncommon opportunistic yeast increasingly recognized as a cause of invasive infections, particularly in immunocompromised individuals and neonates. We report the first case of Kodamaea ohmeri fungemia in a neonate from Pakistan, highlighting the…
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Artikel Jurnal
Sulfonamide resistance, virulence traits, and in-silico target interactions among clinical isolates in Setif, Algeria (2021–2023)
Background and Objectives: Antibiotic-resistant bacteria are a growing global health concern, particularly in developing regions. Sulfonamides, once widely used, now face increasing resistance. This study assessed the prevalence, resistance profiles, and virulences traites of sulfonamide-resistant…
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