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Iranian Journal of Basic Medical Sciences
Scopus
ISSN 2008-3866 · Mashhad University of Medical Sciences · 2.567 artikel di indeks
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Artikel Jurnal Teks lengkap
Comparative analysis of second and third-generation nanobody-based CAR-NK cells targeting PSMA in prostate cancer immunotherapy: In silico and in vitro studies
Objective(s): The use of CAR technology in the treatment of cancer cells is progressing, as well as the use of CAR T-cell in the treatment of blood malignancies is in the clinical trial stage. In this study, have compared the second and third generation CAR expressed in NK cells in dealing with…
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Comparative evaluation of cell types for endothelialization in cardiovascular tissue engineering
Tissue engineering represents a promising approach to overcome the limitations of current vascular grafts by promoting endothelialization. However, the successful fabrication of small-diameter (
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Artikel Jurnal Teks lengkap
Smart micro/nanoneedles for gene delivery
Gene therapy, a transformative field in biomedicine, holds immense promise for treating a wide range of diseases. Smart micro/nanoneedles (MNs/NNs) emerged as non-viral carriers, offering safety and reduced immunogenicity, in addition to precise and controlled gene delivery, and represent promising…
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Investigating the protective effect of zinc supplementation on streptozotocin-induced pancreatic beta-cell damage via the HMGB1/TLR2/MAPK pathway
Objective(s): This study investigated the protective effect of zinc supplementation on insulin release via modulation of the High Mobility Group Box 1 (HMGB1)/Toll-like receptor 2 (TLR2)/mitogen-activated protein kinase (MAPK) signaling pathway in streptozotocin (STZ)-induced pancreatic β-cell…
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Artikel Jurnal Teks lengkap
Nerolidol attenuates cardiac hypertrophy and fibrosis in mice: Modulation of collagen type I, apoptotic and endothelial gene expression
Objective(s): Cardiac hypertrophy is a major pathological feature of cardiovascular disease worldwide. The beneficial effects of terpenes on cardiovascular diseases are well known. In the current study, the cardioprotective effects of nerolidol (NRD), a sesquiterpene alcohol, were evaluated using…
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Synthesis, radiolabeling, and biodistribution evaluation of novel hyperbranched polyglycerols-based radiotracers for targeting PSMA in prostate cancer
Objective(s): Prostate-specific membrane antigen (PSMA) is a valuable target for prostate cancer imaging and therapy. This study aimed to improve the rapid blood clearance and suboptimal tumor uptake and retention of radiolabeled PSMA by developing a hyperbranched polyglycerol (HPG)-based PSMA…
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Investigating the effects of taurine on Aβ-degradation proteins and neurogenesis-related genes in an LPS-induced neuroinflammatory SH-SY5Y cell model
Objective(s): Taurine, a brain-abundant sulfonic acid, shows potential neuroprotective effects and may counter neurodegenerative processes. This study investigated the effects of taurine on neuroinflammation, focusing on Aβ-degrading proteins and gene expression related to neurogenesis in an…
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Sacubitril/Valsartan: Breaking barriers in uterine adhesion and boosting pregnancy outcomes by suppressing inflammation and fibrosis
Objective(s): Intrauterine adhesion (IUA) enhances infertility and is primarily driven by inflammation and fibrosis. Sacubitril/Valsartan (Sac/Val), an angiotensin receptor–neprilysin inhibitor, exhibits anti-inflammatory and anti-fibrotic properties; however, its effects on IUA and reproductive…
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Artikel Jurnal Teks lengkap
Beyond bioactivity: Chitosan macromolecular coatings on titanium surfaces drive osseointegration and immune suppression through targeted epigenetic regulation
Objective(s): To address titanium (Ti) implant failures caused by inadequate osseointegration and persistent inflammation by developing a novel dual-action coating. This coating utilizes a chitosan (CH) matrix to deliver epigenetic pharmaceuticals, 5-azacytidine (AZ) and trichostatin A (TR), onto…
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Artikel Jurnal Teks lengkap
Modulation of CCL5 and CXCR4 as EMT signaling biomarkers by cold atmospheric plasma and Anti-PD-1 combination therapy in melanoma: Insights from integrated bioinformatics and in vitro and in vivo validation
Objective(s): Cold atmospheric plasma (CAP) has emerged as a promising non-thermal modality with anticancer effects. Combining CAP with immune checkpoint blockade (ICB) may enhance therapeutic efficacy, yet the molecular targets underlying this synergy remain incompletely understood.Materials and…
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Trigonelline protects against alcohol-induced brain damage by inhibition of oxidative stress, TLR4/NF-κB/proinflammatory cytokines pathway, and apoptosis
Objective(s): Brain injury is one of the most predominant complications following excessive alcohol consumption. Oxidative, inflammatory, and apoptotic processes are the essential mechanisms involved in alcohol-induced brain damage. Trigonelline is a natural compound that has a variety of…
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Artikel Jurnal Teks lengkap
Protective efficacy of thymol in testicular ischemia/reperfusion injury in rats: A biochemical and histopathological evaluation
Objective(s): Testicular torsion represents a critical urological emergency, characterised by the rotation of the testicle around the spermatic cord and the only treatment option to prevent testicular loss is detorsion. Testicular ischemia/reperfusion injury (IRI) may result from ischemia due to…
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Artikel Jurnal Teks lengkap
Synergistic myelin regenerative, immunomodulatory and anti-inflammatory effects of vanillin and adipose derived stem cells in cuprizone animal model of multiple sclerosis
Objective(s): Vanillin as a potential therapeutic agent along with transplantation of neurotrophic factors secreting cells, is considered a promising treatment for neurological disorders. In this study, the effects of vanillin in combination with human adipose derived stem cells transplantation…
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Artikel Jurnal Teks lengkap
Time-dependent modulation of FXR and Nrf2 signaling in rat models of BDL-induced cholestasis
Objective(s): Farnesoid X receptor (FXR) and nuclear factor erythroid 2-related factor 2 (Nrf2) protect the liver against cholestatic injury by regulating antioxidant and anti-inflammatory pathways. Bile duct ligation (BDL) is a standard model for studying cholestatic liver disease, yet the…
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Artikel Jurnal Teks lengkap
Role of gallic acid in sarcopenia in D-galactose-treated mice
Objective(s): Aging is a natural phenomenon that results in sarcopenia to impair living quality in humans. Gallic Acid (GA) has many biological activities against aging and muscle injury. Our purpose was to clarify possible mechanisms of GA on aged-relevant sarcopenia.Materials and Methods…
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Artikel Jurnal Teks lengkap
In vivo assessment of imoxide and diluted vitamin C’s inhibitory effects on cervical cancer in mice
Objective(s): Cervical cancer, the fourth most common malignancy among women, is strongly associated with high-risk human papillomavirus (HPV) infection. Emerging evidence suggests that hydrogen peroxide, alongside standard therapies, may enhance treatment. This study investigated the effects of…
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Artikel Jurnal Teks lengkap
Involvement of SIRT3 downstream targets ANT1, VDAC, CYPD, and Drp1 in a rat model of hepatic encephalopathy: Therapeutic role of thymoquinone
Objective(s): Hepatic encephalopathy (HE) is a brain disorder linked to hyperammonemia from liver injury. Elevated ammonia levels are known to impair mitochondrial function, the primary energy source for cells. Therefore, this study aimed to evaluate energy-related signaling pathways enhancing…
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Artikel Jurnal Teks lengkap
AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery
Triple-negative breast cancer (TNBC) is defined by profound heterogeneity, dormant metastatic reservoirs, and rapid therapy resistance. Building on our AI-Driven CRISPR Strategies in Breast Cancer framework, CRISPR–Cas9 is emerging as more than a gene-editing tool, capable of restoring circadian…
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Artikel Jurnal Teks lengkap
Hepatoprotective effect of hUC-MSC secretome in LPS-induced HepG2 cells
Objective(s): This study aimed to evaluate the cytotoxicity and hepatoprotective effects of human umbilical cord mesenchymal stem cell–derived secretome (hUCMSC-Sec) in lipopolysaccharide (LPS)-induced HepG2 cells as an in vitro model of liver inflammation.Materials and Methods: hUCMSC-Sec was…
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Artikel Jurnal Teks lengkap
Emerging trends in nanomedicine: The role of RNAi-based therapies and onpattro’s clinical journey
Nanomedicine has transformed therapeutic strategies by enabling precise delivery of nucleic acid-based drugs, including small interfering RNA (siRNA), messenger RNA (mRNA), and antisense oligonucleotides. A landmark achievement is Onpattro (patisiran), the first FDA-approved RNAi therapy, which…
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