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Middle East Journal of Cancer
Scopus
ISSN 2008-6709 · Shiraz University of Medical Sciences · 775 artikel di indeks
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Artikel Jurnal Teks lengkap
Modulation of CTLA-4, STAT3 and LAG-3 Expression by Ibrutinib and Idelalisib in Leukemic Cells of Patients with Chronic Lymphocytic Leukemia
Background: Small molecule inhibitors are the new therapeutic approaches for many cancers, but their exact mechanisms in tumor evasion and expansion remains unknown. The present study aimed to evaluate the expression of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), lymphocyte-activation…
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Evaluation of Toxicity Profiles of Lacrimal Glands in Nasopharyngeal Carcinoma Patients Treated with Volumetric Modulated Arc Therapy
Background: Lacrimal gland forms the integral part of tear film production. In view of close proximity to treatment portals, the present study aimed to investigate the relationship between lacrimal gland radiotherapy dose and its toxicity among patients treated with volumetric modulated arc therapy…
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Pentoxifylline Mouthwash: A Novel Approach to Managing Chemotherapy-Induced Oral Mucositis, a Randomized, Double blind, and Placebo-controlled Clinical Trial
Background: Chemotherapy-induced oral mucositis (CIOM) is a prevalent inflammatory condition among cancer patients. Pentoxifylline (PTX), a phosphodiesterase inhibitor with established anti-inflammatory properties, has shown potential in CIOM management. The present study investigated the efficacy…
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Breast Cancer Susceptibility Genes in Estrogen Receptor Signaling Pathway in a Southern Indian Population
Background: Ovarian cancer starts in the ovaries and is hard to detect early due to vague symptoms. The present study aimed to investigate whether the ESR1 gene is linked to breast cancer. Also, we aimed to examine whether genetic changes in the ESR1 gene affect breast cancer risk through estrogen…
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Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation
Background: Deep inspiration breath-hold (DIBH) technique is superior to the free breathing (FB) in irradiation of breast and chest wall. The radiation exposure of liver, lungs and heart is decreased considerably when right breast cancer (RBC) is treated with DIBH. The present study aimed to reduce…
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The Effect of Neoadjuvant Chemoradiotherapy in Converting Unresectable and Locally Advanced Pancreatic Adenocarcinoma to Resectable Status: A Systematic Review and Meta-analysis
Background: Neoadjuvant chemoradiotherapy (NCRT) is increasingly used in locally advanced unresectable pancreatic adenocarcinoma. In the present study, we systematically evaluated the effects of NCRT on downstaging, resectability, and survival.Method: A systematic review and meta-analysis of 70…
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Dosimetric Evaluation of Two LINAC-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis
Background: Stereotactic radiosurgery (SRS) relies on precise, highly conformal radiation with sharp dose falloff to protect adjacent normal brain tissue. Differences in multileaf collimator (MLC) configuration and planning system algorithms can affect dosimetric performance and delivery…
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Differentiating Benign from Malignant Papillary Breast Lesions: Insights from a Multi-Modality Imaging Approach
Background: Papillary breast lesions are a heterogeneous group of breast lesions with overlapping benign and malignant imaging features, often posing diagnostic and management challenges. The present study aimed to evaluate the imaging characteristics of papillary breast lesions using ultrasound…
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Clinical Evaluation of LncRNA XIST and TUG1 Expression Levels in Patients with Hepatocellular Carcinoma
Background: Among long non-coding RNAs, as key regulators in oncogenesis, X-inactive specific transcript (XIST) and Taurine upregulated 1 (TUG1) are frequently reported in various cancers. The aim of this study was to investigate the expression patterns and potential clinicopathological and…
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Long-term Breast Tumor Control with Brachytherapy and External Beam Radiotherapy: A Case Report
While surgical resection of the primary tumour and regional nodes is part of the standard algorithm for the treatment of early-stage invasive breast carcinomas, not all patients are surgical candidates or agree for surgery. This case report is about one such patient who refused surgery for a biopsy…
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Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma
Background: Long non-coding RNAs (LncRNAs) have been implicated in various biological processes and tumorigenesis. PANDAR is one of the long non-coding RNAs implicated in the development of multiple cancers, which has yet to be investigated for its clinical significance in hepatocellular carcinoma…
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Venetoclax Drives Significant Shifts in BIM and BCL-2 but not MCL-1 Gene Expression in a Mouse Model of Acute Lymphoblastic Leukemia
Background: T and B acute lymphoblastic leukemia (T, B-ALL) has seen improved survival rates with intensified chemotherapy, but therapy-resistant or refractory ALL remains a significant clinical challenge. This study examined the inhibitory effects of Venetoclax drug on the apoptosis gene to…
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Investigating the Role of Escherichia coli Infection in the Pathogenesis of Bladder Cancer: A Comparative Genomics Interaction
Background: Bladder cancer (BC) is the 10th most common cancer worldwide. Microorganisms, including bacteria, may contribute to urological tumor development. Escherichia coli, responsible for 70% of urinary tract infections, has been linked to BC progression. This study investigated the potential…
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Investigating the Protective Effects of Atorvastatin against Radiotherapy-Induced Gastrointestinal Toxicity in Abdominal and Pelvic Cancers: A Randomized, Double-Blind, Placebo-Controlled Trial
Background: Radiotherapy (RT) for pelvic cancers often causes gastrointestinal toxicity. While statins show promise in reducing radiation-induced injury through anti-inflammatory properties, their impact on acute toxicity remains unclear. The aim of this study was to evaluate the effects of…
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Hairy Cell Leukemia Variant Masquerading as Acute Leukemia: A Rare Case Report
The key purpose of this report is to present an uncommon case of hairy cell leukemia variant (HCLv). HCLv is found to be a striking clinico-pathological condition which encompasses the features of classical hairy cell leukemia (cHCL) as well as B cell prolymphocytic leukemia. It is a rather rare…
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Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer
Background: Improvement in quality of life and palliation of symptoms forms the primary end point in patients unfit for definitive treatment modalities. Quad-shot like radiotherapy aims to achieve these objectives with addition of chemotherapy in advanced head and neck malignancy.Method: In this…
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Pelvic Nodal Irradiation in Muscle Invasive Bladder Cancer (MIBC)
Background: Bladder cancer preservation treatment achieved 5/10-year overall survival rates comparable to those of radical cystectomy. Bladder-preserving trials have recommended coverage of pelvic lymph nodes (LN) in radiation portals (micrometastases in pelvic LN 25 to 44%). Gemcitabine-based…
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Primary Hodgkin's Lymphoma of Thyroid Simulating Subacute Thyroiditis: A Case Report
Primary thyroid lymphoma is rare, with the majority of cases being non-Hodgkin and occurs in patients with autoimmune thyroid disease. Primary thyroid Hodgkin’s lymphoma is extremely rare and only about 20 previous cases have been reported. We report a 24-year-old woman presented with one month…