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Journal of Diabetes Investigation
Scopus
ISSN 2040-1124 · Wiley · 1,809 articles in the index
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Journal Article
A phase 1 single and multiple ascending dose study of orforglipron in Japanese participants with type 2 diabetes
ABSTRACT Introduction We aimed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of orforglipron in Japanese participants with type 2 diabetes. Materials and Methods This was a double‐blind, placebo‐controlled, randomized, phase 1 study. In…
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Journal Article
Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized…
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Journal Article
Differential impact of COVID‐19 on change in body composition in young and older individuals with diabetes in the post‐COVID‐19 Era
Abstract Aims/Introduction COVID‐19 containment measures in Japan, characterized by intermittent states of emergency (SE) without strict lockdowns from April 2020 to September 2021, may have significantly impacted lifestyle, weight, and body composition in individuals with diabetes. This study…
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Journal Article
Electrophysiological diagnosis using the coefficient of variation of R‐R intervals and a point‐of‐care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs
ABSTRACT Aims/Introduction While treatment for diabetic polyneuropathy (DPN) is still developing, progress has stagnated. The alignment between pathological neurodegeneration in DPN and patients' subjective symptoms is often low, yet these symptoms are frequently used for diagnosis. This reliance…
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Journal Article
Outcomes of insulin treatment using an automated insulin delivery system from the onset of type 1 diabetes in pediatric patients—A 1‐year retrospective, observational, two‐center study
ABSTRACT Introduction MiniMed 780G was the first automated insulin delivery (AID) system approved in Poland. Although it has been studied extensively, there are relatively less data regarding its use in children with type 1 diabetes from the onset of the disease. We aimed to evaluate and compare…
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Journal Article
Diabetic peripheral neuropathy as measured using a point‐of‐care sural nerve conduction device is associated with a faster decline in renal function in patients with type 2 diabetes
ABSTRACT Aims/Introduction Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus and may be linked to renal function decline. However, the prognostic value of point‐of‐care nerve conduction devices such as DPN‐Check® for renal outcomes remains unclear. Materials and…
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Journal Article
Risk factors for persistent decline in eGFR of Japanese patients with diabetes: Analysis using a large‐scale diabetes registry J‐DREAMS
ABSTRACT Aims/Introduction This study aimed to identify clinical predictors associated with sustained decline in estimated glomerular filtration rate (eGFR) among Japanese individuals diagnosed with diabetes mellitus. Materials and Methods We conducted a retrospective analysis using J‐DREAMS (Japan…
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Journal Article
Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome—A case report
ABSTRACT A 48‐year‐old man was referred to our hospital due to hyperglycemia. His casual plasma glucose and glycated hemoglobin A1c were 25.2 mmol/L and 8.7%, respectively. He had undergone bilateral cataract surgery in his 30s. He exhibited a bird‐like face contour, gray hair, alopecia, and…
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Journal Article
Predictors of glycemic control with imeglimin for type 2 diabetes: Results of machine learning analyses using clinical trial data
ABSTRACT Introduction Identifying patient characteristics predictive of treatment response is crucial for optimizing type 2 diabetes outcomes. Using data from three phase 2/3 imeglimin trials in Japan, this analysis applied machine learning to determine characteristics associated with HbA1c…
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Journal Article
Lower glycemic status was associated with pancreatic cancer risk in prediabetes, but not in diabetes: A nationwide cohort study
ABSTRACT Introduction Hyperglycemia or diabetes mellitus (DM) is a well‐known risk factor for pancreatic cancer, but it is uncertain whether well‐controlled glycemic status can affect the pancreatic cancer incidence rate. Methods This study used 2,993,519 individuals who underwent four consecutive…
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Journal Article
The difference in type 2 diabetes care between the National Health Insurance beneficiaries and public assistance recipients in Japan: A retrospective cohort study based on claims data in a municipality
ABSTRACT Aims/Introduction We examined the differences in diabetes care between public assistance recipients (PARs), exempt from medical costs and guaranteed a minimum income, and the National Health Insurance (NHI) beneficiaries, covering non‐employed and self‐employed individuals with some cost…
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Journal Article
The biology of PKM2 in the metabolism and senescence in diabetic kidney disease
ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from…
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Journal Article
Investigation and future trend prediction of disease burden of chronic kidney disease due to diabetes mellitus type 2 globally and in China from 1990 to 2021
ABSTRACT Objective To analyze the disease burden of chronic kidney disease due to diabetes mellitus type 2 (CKD due to diabetes mellitus type 2) in China and the global population from 1990 to 2021, and to predict the future trend of the population. Methods Joinpoint regression quantifies trends by…
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Journal Article
Impact of glycemic variability on early detection of sudomotor dysfunction: Implications for early intervention and personalized treatment
ABSTRACT Background This study investigates the impact of glycemic variability on sudomotor dysfunction in type 2 diabetes mellitus. Methods A total of 206 type 2 diabetes mellitus patients and 34 healthy controls were included. Sweat function (SF) was assessed using electrochemical conductance of…
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Journal Article
Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two‐sample Mendelian randomization
ABSTRACT Aims/Introduction Leukocytes are implicated in the inflammatory cascades of diabetic retinopathy (DR), but their causal roles remain ambiguous. This study employed a two‐sample Mendelian randomization (MR) analysis to dissect the causal effects of circulating leukocyte counts on DR risk…
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Journal Article
Advances in insulin pump systems lead to stepwise improvements in treatment satisfaction in people with type 1 diabetes: A single‐center retrospective study
ABSTRACT Introduction Transition from the MiniMed™ 770G hybrid closed loop (HCL) to the MiniMed™ 780G advanced hybrid closed loop (AHCL) insulin pump system has been demonstrated to improve glycemic control in people with type 1 diabetes (T1D). However, evidence regarding changes in treatment…
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Journal Article
Incidence of treatment intensification based on HbA1c trends in people with type 2 diabetes
ABSTRACT Aims Clinical inertia, the failure to intensify treatment despite unmet glycemic goals, is a key factor in poor glycemic management for type 2 diabetes. No studies have defined clinical inertia based on HbA1c trends. In this study, we aimed to assess treatment intensification according to…
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