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Antiviral Therapy
Scopus
ISSN 2040-2058 · SAGE Publishing · 100 artikel di indeks
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Artikel Jurnal
Kidney function parameters in South African children living with HIV on antiretroviral therapy
Background We evaluated longitudinal kidney function in children with perinatally acquired HIV (CWH) compared with HIV-negative controls. Methods We analyzed data from an observational study in Johannesburg, South Africa (2013–2018), including 220 CWH on non–tenofovir regimens and 220 controls…
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Artikel Jurnal
Week 96 resistance analysis in participants receiving bictegravir/lenacapavir in the phase 2 ARTISTRY-1 study
Background ARTISTRY-1 is an ongoing Phase 2/3 study evaluating the safety and efficacy of once-daily oral bictegravir (BIC) + lenacapavir (LEN) in virologically suppressed (VS; HIV-1 RNA
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Artikel Jurnal
COMbination therapy with baloxavir and oseltamivir 1 for hospitalized patients with influenza: The pragmatic COMBO 1 randomized controlled trial
Background COMBO 1 compared time to cessation of viral shedding (TCVS) among hospitalized influenza patients treated with oseltamivir plus a single dose of baloxavir vs. oseltamivir alone. Methods In a quadruple-blinded, placebo-controlled parallel group multicenter randomized controlled trial…
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Artikel Jurnal
Factors associated with immunological non-response in HIV patients receiving antiretroviral therapy in Southeast Asia: A systematic review
Objective This systematic review summarizes factors associated with immunological non-response (INR) among people with HIV on antiretroviral therapy (ART) in Southeast Asia. Methods We conducted a systematic search of PubMed, ScienceDirect, DOAJ, and Lens.org for studies published between 2010 and…
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Artikel Jurnal
Combination antiviral and anti-CMV immunoglobulin therapy for CMV infection: A case-control study
Background Intravenous hyper-immune anti-cytomegalovirus immunoglobulins (CMV-IG) therapy are licensed for prophylaxis, yet their therapeutic value in established CMV disease remains poorly defined. We aimed to evaluate the clinical and virological impact of adjunctive CMV-IG in combination with…
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Artikel Jurnal
Safety and efficacy of deltoid intramuscular long-acting cabotegravir and rilpivirine, a case series
Objective The objective was to evaluate the safety, pharmacokinetics and efficacy of an alternative deltoid site for CAR-LA. Design This is a prospective cohort of people living with HIV (PLWHIV) switching for intramuscular long acting cabotegravir and rilpivirine (CAR-LA). Methods Clinical and…
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Artikel Jurnal
Epidemiology and clinical management of cytomegalovirus infection in transplant recipients in Central and Eastern Europe – a physician survey
Background Posttransplant cytomegalovirus (PT-CMV) infection remains a challenging complication and a major cause of morbidity and mortality in transplant recipients. Methods This cross-sectional study surveyed physicians treating solid organ and hematopoietic stem cell transplantation recipients…
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Artikel Jurnal
It’s about time: The association between abacavir and cardiovascular disease
Data from the REPRIEVE trial have been used to study the association between treatment with abacavir and cardiovascular disease in people with HIV. Past exposure to abacavir before the trial was found to be just as risky as exposure during the trial. This calls into doubt the widely accepted…
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Nirmatrelvir treatment duration and frequency of COVID-19 rebound
Background Nirmatrelvir has been shown to reduce morbidity and mortality associated with COVID-19. However, it is underutilized due to concerns regarding COVID-19 symptom rebound following nirmatrelvir’s standard 5-day course. This study aims to identify and evaluate a nirmatrelvir dosage regimen…
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Artikel Jurnal
Clinical outcomes among COVID-19 patients initiated on molnupiravir in Denmark – A national registry study
Background Molnupiravir (MOV) is an orally bioavailable ribonucleoside with antiviral activity against all tested SARS-CoV-2 variants. We describe the demographic, clinical, and treatment characteristics of non-hospitalized Danish patients treated with MOV and their clinical outcomes following MOV…
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Artikel Jurnal
Increased insulin resistance following switch from efavirenz to cobicistat-boosted elvitegravir
Background Integrase strand transfer inhibitors (INSTIs) have been associated with excess weight gain in people living with HIV compared to other antiretroviral agents. The mechanisms that underlie these effects are not well defined. Thus, we aimed to examine the effects of switching to…
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Artikel Jurnal
Functional foods and immune system: A sustainable inhibitory approach against SARS-COV-2
Background: COVID-19 has become the center of attention since its outbreak in December 2019. Despite the discovery of its preventive vaccine, role of healthy immune system is undebatable. Functional foods are continuously hunted as a promising option for a safe natural therapeutic treatment…
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The diagnostic significance of the C-reactive protein (CRP) in HIV/TB coinfection: A systematic review and meta-analysis
Background Drug-resistant Mycobacterium tuberculosis strains have challenged efforts to combat tuberculosis (TB), a major global killer. C-reactive protein (CRP) shows promise as a biomarker for TB screening, particularly in HIV-positive cases, with demonstrated sensitivity and specificity in…
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Artikel Jurnal
Pediatric darunavir/cobicistat fixed-dose combination tablet for dispersion: Bioequivalence versus separate agents in healthy participants and acceptability in children living with human immunodeficiency virus-1
Objective The bioequivalence of the simplified protease-inhibitor-based HIV-1 antiretroviral regimen darunavir/cobicistat (DRV/COBI) 600/90-mg fixed-dose combination (FDC) tablet dispersed in water was evaluated in healthy adults and swallowability in children living with HIV aged >3 years and…
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Artikel Jurnal
Evaluation of combining the PDX analogue AN-137B with oseltamivir in a mouse model of severe influenza A (H1N1) infection
Severe influenza infections involve an exacerbation of the pro-inflammatory response, which is influenced by both viral and host factors. Protectins PD1 and PDX previously demonstrated anti-influenza activity as well as anti-inflammatory properties. We recently reported that the combination of…
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Artikel Jurnal
A review of photodynamic therapy for the treatment of viral skin diseases
Introduction: Photodynamic therapy (PDT) is a two-stage treatment method making use of light energy and a photosensitizer in the presence of oxygen. PDT has already proved to bring good anti-inflammatory and anti-proliferative effects in the treatment of actinic keratosis, squamous cell carcinoma…
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Artikel Jurnal
Durability of multi-drug antiretroviral therapy (mega-ART) in treatment-experienced people with HIV in the ARCA database
Objective To explore the durability of multi-drug antiretroviral regimens in treatment-experienced PWH. Design This retrospective observational study including PWH who started mega-ART regimens between 1 January 2009 and 31 December 2019, selected from the ARCA cohort. Methods Time-dependent events…
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A Phase 1 study of the safety, tolerability, and pharmacokinetics of ALG-000184 (pevifoscorvir sodium), a novel Class E capsid assembly modulator, in healthy participants
Background Class E (empty) capsid assembly modulators (CAM-Es) inhibit HBV capsid assembly, pregenomic RNA encapsidation preventing formation the establishment of covalently closed circular HBV DNA (ccDNA). ALG-000184 (pevifoscorvir sodium), is a prodrug of the Class E CAM ALG-001075. Methods…
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Artikel Jurnal
Cost-effectiveness of tenofovir alafenamide fumarate for treatment of chronic hepatitis B: Evidence from a tertiary hospital in Vietnam
Background This study aims to evaluate the cost-effectiveness of tenofovir alafenamide fumarate (TAF) versus tenofovir disoproxil fumarate (TDF) for chronic hepatitis B treatment from a payer’s perspective in a limited-income context like Vietnam. Methods A Markov model was developed to estimate…
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Artikel Jurnal
Pharmacokinetic and mass balance characterization of [C] RAY1216, a SARS-CoV-2 M inhibitor, in healthy Chinese male subjects
Background RAY1216 is an alpha-ketoamide-based peptide inhibitor of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) major protease (M pro ). This study evaluated the absorption, distribution, metabolism and excretion of [ 14 C]-labelled RAY1216 by oral administration. Research…