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Therapeutic Advances in Hematology
Scopus
ISSN 2040-6215 · SAGE Publishing · 474 artikel di indeks
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Artikel Jurnal
Efficacy and safety of chimeric antigen receptor T-cell therapy in relapsed/refractory large B-cell lymphoma: a systematic review and meta-analysis
Background: Individuals diagnosed with relapsed or refractory large B-cell lymphoma (R/R LBCL) typically exhibit a dismal prognosis when treated with conventional therapeutic modalities. CD19—targeted chimeric antigen receptor T (CAR-T) cell therapy has brought about a paradigm shift in the…
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Artikel Jurnal
Perioperative discovery of KLKB1 c.451dupT mutation causing prekallikrein deficiency in a Saudi child: A case report of safe surgery despite isolated severe aPTT prolongation
Prekallikrein deficiency, a rare autosomal recessive disorder, results in isolated prolongation of activated partial thromboplastin time (aPTT) without associated bleeding symptoms. This condition often complicates preoperative screenings and can lead to unnecessary testing and healthcare…
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Artikel Jurnal
Paroxysmal nocturnal hemoglobinuria perspective: Lactate Dehydrogenase (LDH) as a surrogate endpoint
Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare, acquired, life-threatening blood disorder that results in uncontrolled complement activity and intravascular hemolysis (IVH). The associated complications include anemia, fatigue, abdominal pain, hemoglobinuria, erectile dysfunction, and…
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Artikel Jurnal
Longitudinal prospective analysis of organ stiffness and cardiac function in patients with myelofibrosis treated with ruxolitinib
Background In myeloproliferative neoplasms (MPNs), fibrosis occurs not only in the bone marrow but also in extramedullary organs such as the liver and spleen, reflected by increased tissue stiffness. Patients with MPNs frequently present with echocardiographic signs of cardiac dysfunction, which…
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Artikel Jurnal
Precision medicine in acute lymphoblastic leukemia: A narrative review of current strategies and future directions
Acute lymphoblastic leukemia (ALL) is a genetically heterogeneous hematologic malignancy and the most common cancer in children, with significant morbidity and mortality in adults. Advances in molecular diagnostics and targeted therapies have shifted treatment from uniform chemotherapy toward…
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Artikel Jurnal
Molecular overlap between primary immune thrombocytopenia and inherited platelet disorders: A pediatric case report with a novel heterozygous ITGB3 variant identified by next-generation sequencing
Primary immune thrombocytopenia (ITP) in children is typically self-limited. However, persistent and treatment-resistant cases require evaluation of alternative pathogenic mechanisms. We report a 12-year-old female with persistent ITP unresponsive to corticosteroids and intravenous immunoglobulin…
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Artikel Jurnal
Impact of luspatercept in beta-thalassemia major with alloimmunization: A case report
Patients with Beta (β)-thalassemia require regular blood transfusions. The presence of red blood cell (RBC) alloantibodies can complicate transfusion treatment. This can lead to delays in obtaining compatible blood, and in some case temporarily rendering blood transfusion impossible. We present a…
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Artikel Jurnal
Treatment preferences of people with hemophilia and caregivers: a plain language summary
Summary What is this summary about? This is a summary of the results from a study that looked at the treatment preferences of people with hemophilia and caregivers of children with hemophilia in the US and UK. The study was published in a research journal called Haemophilia. People with hemophilia…
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Artikel Jurnal
A plain language summary of the BASIS study looking at people living with severe hemophilia A or B with inhibitors and being treated with marstacimab
Summary What is this summary about? This summary describes a clinical study looking at how well marstacimab works in people living with hemophilia with inhibitors. The study was published in the medical journal Blood . Hemophilia is caused by not having enough blood clotting factors, which are…
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Artikel Jurnal
Effect of marstacimab in young people living with severe hemophilia A or moderate to severe hemophilia B without inhibitors: A plain language summary from the BASIS study
Summary What is this summary about? This summary describes a study that looked at how well the study treatment (marstacimab) works in people living with hemophilia. The summary describes how well marstacimab reduced bleeding episodes in young people (adolescents) 12 to 17 years old. Hemophilia is a…
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Artikel Jurnal
Corticosteroids plus statins in patients with primary immune thrombocytopenia and hyperlipidemia: A multicenter retrospective cohort study
Background Hyperlipidemia is prevalent in primary immune thrombocytopenia (ITP) and may exacerbate bleeding severity and compromise treatment responses. Statins possess lipid-lowering and anti-inflammatory properties, but their influence on corticosteroid therapy in ITP patients with hyperlipidemia…
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Artikel Jurnal
A real-world, multi-center, prospective, observational study for paroxysmal nocturnal haemoglobinuria (PNH) in China: Baseline characteristics, disease burden and treatment patterns
Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare life-threatening hematologic disorder with high thromboembolic mortality. In the context of large patient population and limited use of complement inhibitors, the clinical characteristics and disease progression of patients in China…
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Artikel Jurnal
Efficacy and safety of daratumumab-based quadruplet therapy vs non-daratumumab-based triplet therapy in newly diagnosed multiple myeloma patients: A GRADE assessed systematic review and meta-analysis of randomized controlled trials
Background Multiple myeloma (MM) is the second most common hematologic malignancy worldwide. Recent therapeutic innovations, including the addition of daratumumab to standard regimens, have shown promising improvements in patient outcomes. Objectives This study aims to compare the efficacy and…
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Artikel Jurnal
Efficacy and safety of different TPO-RAs combined with cyclosporine in the treatment of NSAA
Background TPO receptor agonists (TPO-RAs) have significantly improved the treatment outcomes of patients with aplastic anemia. Currently, three small-molecule TPO-RAs (eltrombopag, hetrombopag, and avatrombopag) are available for clinical use and work well. Objectives This article aims to compare…
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Artikel Jurnal
Fulminant extramedullary relapse of multiple myeloma with rare cardiac, vascular, and multivisceral involvement: A case report
Multiple myeloma (MM) is a plasma cell malignancy that typically follows a protracted clinical course. Extramedullary disease (EMD) represents an aggressive manifestation of MM with a relatively low incidence, traditionally involving the skin and soft tissues. While MM usually progresses…
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Artikel Jurnal
Hypoplastic acute myeloid leukemia with aberrant lymphoid antigen expression and fusion: A rare case report and literature review
Ewing sarcoma breakpoint region 1 ( EWSR1 ):: Fifth Ewing variant ( FEV )-positive acute leukemia is exceptionally rare, and its clinicopathological features, molecular profile, and optimal treatment remain poorly defined. Here, we report a case of acute myeloid leukemia (AML) with bone marrow…
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Artikel Jurnal
Immune and cytokine landscape differs between cytopenic and proliferative phenotypes in primary myelofibrosis
Background Cytopenia represents a distinct clinical phenotype in primary myelofibrosis (PMF), often associated with advanced disease and poor prognosis. We propose that while a common driver mutation initiates the disease, the clinical phenotype of PMF is shaped by inter-individual variability in…
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Artikel Jurnal
Identification of novel and fusion transcripts in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematologic malignancy caused by the malignant proliferation and differentiation block of immature myeloid cells (blasts) in the bone marrow. The pathogenesis, diagnostic classification, treatment, and prognosis of AML are fundamentally linked to the accumulation…
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Artikel Jurnal
Romiplostim during pregnancy in refractory primary immune thrombocytopenia: Literature review and case series
Primary immune thrombocytopenia (ITP) in pregnancy presents significant therapeutic challenges, particularly when refractory to standard treatments such as corticosteroids, intravenous immunoglobulin, and immunosuppressants. Data on thrombopoietin receptor agonists (TPO-RAs) during pregnancy remain…
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Artikel Jurnal
Targeting CD38 in relapsed /refractory T-cell acute lymphoblastic leukemia/lymphoma: A systematic review of daratumumab-based therapy
Background Relapsed/refractory (R/R) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) has poor outcomes and limited salvage options. Objectives: To evaluate the efficacy and safety of daratumumab-based therapy in R/R T-ALL/T-LBL. Design Systematic review of observational reports. Methods…