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Therapeutic Advances in Chronic Disease
Scopus
ISSN 2040-6231 · SAGE Publishing · 542 articles in the index
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Journal Article
Factors associated with disease knowledge and medication adherence among rheumatoid arthritis patients attending a private rheumatology clinic: A cross-sectional study
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires long-term pharmacotherapy and self-management. Disease knowledge and medication adherence are essential for achieving optimal outcomes, but remain under-researched in low-resource settings such as Nepal. Objective…
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Journal Article
Frailty and its association with mental health and quality of life in multiple sclerosis: A cross-sectional study
Background: With the increasing median age of people with multiple sclerosis (MS), age-related syndromes such as frailty have emerged as new challenges to patient well-being. Prior research on frailty in MS has primarily focused on physical aspects, leaving the relationship between frailty and…
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Journal Article
Practitioner’s perception of myasthenia gravis management recommendations in clinical practice: a cross-sectional survey study
Background: Myasthenia gravis (MG) is a chronic, fluctuating disease whose unique natural history complicates designing therapeutic trials. The evidence on which many MG management recommendations are based is limited. Objective: To determine the degree of knowledge, agreement, and application of…
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Journal Article
Level of medication non-adherence among ambulatory patients with dyslipidemia and comorbid illness in Northwest Ethiopia: a multicenter cross-sectional study
Background: Antilipidemic therapy adherence to medication among patients with dyslipidemia and type 2 diabetes mellitus (T2DM) remains suboptimal, particularly in developing countries. Poor adherence to lipid-lowering therapy is associated with a significantly higher risk of major adverse…
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Journal Article
The impact of body mass index on periodontitis: a cross-sectional study
Background: Obesity is a significant public health concern linked to various health complications, including periodontitis. This study uniquely integrates multiple obesity indicators (body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR)) alongside clinical periodontal…
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Journal Article
The relationship between MAFLD and CVD in a health check-up Chinese population: a prospective cohort study
Background: Cardiovascular disease (CVD) has emerged as the most significant complication and leading cause of death among metabolic-associated fatty liver disease (MAFLD). Objectives: This study aims to investigate the CVD risk among MAFLD subgroups. Design: Data of participants from June 2017 to…
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Journal Article
Metabolic dysfunction-associated steatotic liver disease: an emerging comorbidity in COPD
Chronic obstructive pulmonary disease (COPD) and metabolic dysfunction-associated steatotic liver disease (MASLD) are highly prevalent conditions that frequently coexist. MASLD, now the leading cause of chronic liver disease globally, affects up to 25% of the population and is increasingly…
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Journal Article
Smoking, alcohol consumption, and new-onset impaired glucose metabolism in male patients with type 1 autoimmune pancreatitis: a retrospective cohort study
Background: Type 1 autoimmune pancreatitis (AIP) is more prevalent among males, a significant proportion of whom are known to smoke and consume alcohol, both of which can cause damage to the pancreas. AIP is associated with the new-onset impaired glucose metabolism (NO-IGM). However, it remains…
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Journal Article
Joint effects of prognostic nutritional index and skeletal muscle index on prognosis of decompensated cirrhosis: a retrospective cohort study
Background: Liver cirrhosis, characterized by chronic inflammation, is frequently complicated by malnutrition. Nutritional indices, such as the prognostic nutritional index (PNI) and the skeletal muscle index (SMI), calculated as the muscle area quantified via CT scans at the third lumbar vertebra…
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Journal Article
The evolving roles of fetuin-A in type 2 diabetes mellitus and its potential clinical implications: a review
Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition marked by insulin resistance, decreased insulin production, and persistent low-grade inflammation. The prevalence of T2DM has increased significantly in recent decades; as a result, it is now regarded as one of the fastest-growing…
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Journal Article
Treatment of vitiligo with ruxolitinib cream in the TRuE-V1 and TRuE-V2 studies: a plain language summary of publication
Summary What is this summary about? • This is a summary of a research article published in a medical journal that describes the main results from two studies called TRuE-V1 and TRuE-V2 • These studies looked at the use of ruxolitinib cream to treat vitiligo , a long-term condition where white…
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Journal Article
A narrative review on the safety of glatiramer acetate in multiple sclerosis: focus on Europe
Glatiramer acetate (GA) has been a pivotal therapy for relapsing multiple sclerosis (MS) due to its favorable safety profile. Long-term data spanning decades demonstrate its continued use in diverse patient populations. Adverse events include manageable localized injection site reactions…
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Journal Article
Patterns of use and dose optimization of renin-angiotensin system modulators among chronic heart failure patients with reduced ejection fraction in resource-limited settings: a multicenter cohort study
Background: Optimal use of renin-angiotensin system (RAS) modulators plays a crucial role in improving the outcomes for chronic heart failure (CHF) patients with reduced ejection fraction (rEF). Despite their established benefits, there is limited evidence regarding real-world prescribing patterns…
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Journal Article
The evidence for ketamine treatment in older adults with psychiatric illness: a scoping review
Background: Ketamine, an N-methyl-D-aspartate antagonist, has been used for decades as an anesthetic agent, but more recently it has been studied in psychiatric illness. Though ketamine has been investigated for use in the general population, fewer studies have investigated the efficacy and…
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Journal Article
Short- and long-term complications of insulin pump therapy in children and adolescents with type 1 diabetes: a multicenter cross-sectional study from Saudi Arabia
Background: Insulin pump therapy improves glycemic control in children with type 1 diabetes but is associated with technical and dermatological complications that can impact adherence. Research on these adverse effects in pediatric populations is limited. Objectives: This study aimed to evaluate…
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Journal Article
Endoscopic treatment as secondary prophylaxis ameliorates short-term mortality for acute esophagogastric variceal bleeding in older patients with cirrhotic hepatocellular carcinoma
Background: Acute esophagogastric variceal bleeding (AEGVB) is a common complication of liver cirrhosis and hepatocellular carcinoma (HCC). It is unclear if older patients with cirrhotic HCC benefit from endoscopic treatment as secondary prophylaxis for AEGVB in short term. Objectives: We aim to…
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Journal Article
The profound implications of mitochondrial myopathy on activities of daily living: an observational qualitative study of standardized structured and semi-structured patient interviews
Background: The impact of Mitochondrial Myopathy (MM) symptoms on functional ability across activities of daily living (ADLs) has not been fully characterized, nor is it understood how MM patients define their key symptoms. Furthermore, it is unclear what MM individuals perceive as a clinically…
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Journal Article
Joint effects of sodium intake and circadian rhythm of urinary sodium excretion on prognosis of chronic kidney disease: a prospective study
Background: Sodium harmony is closely correlated with the progression of chronic kidney disease (CKD). Objectives: The current study aims to explore the significance of the circadian rhythm of urinary sodium excretion in CKD management and to help establish individualized salt restriction…
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Journal Article
Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis
Background: In the context of the COVID-19 pandemic, there is growing concern about the virus’s effects on individuals with existing endocrine disorders such as primary aldosteronism (PA). Objectives: This study explores the potential relationship between PA and the risk of developing obstructive…
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Journal Article
Relationship of sKlotho with hemoglobin level in patients undergoing maintenance hemodialysis: a case–control study
Background: Klotho is a kidney-derived protein that is involved in various kidney diseases. The role of serum soluble Klotho (sKlotho) in the anemia of patients undergoing hemodialysis has not been well characterized. Objective: We aimed to characterize the relationship between sKlotho and…