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Correction: The rise of rat models for Duchenne muscular dystrophy and therapeutic evaluations

Frederic Relaix; Peggy Lafuste; Valentina Taglietti dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regeneration

Jinfang Liu; Na Li; Shuwei Jing dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Skeletal muscle regeneration is a dynamically complex and multistage process in which balanced polarization of M1/M2 macrophages plays a crucial role. M1/M2 macrophages defend against microbial invasion, regulate tissue repair by engulfing pathogens and cellular debris, and…

The contribution of skeletal muscle interstitial cells to myogenesis

Fayez Issa; Frédéric Relaix; Joana Esteves de Lima

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract The developmental origin of skeletal muscle cell lineages has been extensively studied in the last 50 years. PAX3 + /PAX7 + myogenic progenitors are the foundation for skeletal muscle development and give rise to muscle satellite cells that support skeletal muscle postnatal growth…

Humidity impacts volatile anesthetic and heat responses of malignant hyperthermia susceptible mice

Miao He; Sheila Riazi; Luuk R. van den Bersselaar dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Malignant Hyperthermia (MH) is characterized by life-threatening whole-body hyperthermic reactions triggered by volatile anesthetics in susceptible individuals. MH susceptibility (MHS) and exertional heat stroke (EHS) are linked to mutations in the type I ryanodine receptor…

Non-regenerative myogenesis in adult skeletal muscles: myofiber death-independent muscle satellite cell expansion

So-ichiro Fukada; Atsushi Kubo; Takashi Yamada dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Muscle regeneration processes triggered by injuries following myofiber death have been extensively investigated owing to the availability of suitable in vivo animal models, including disease models. During muscle regeneration, skeletal muscle-resident stem cells, also known as muscle…

Regenerative Index: a method to assess muscle regeneration in patients with Duchenne muscular dystrophy

Johnathan K. Smid; Charis A. McPherson; Jacob G. Monast dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Duchenne muscular dystrophy (DMD) is a devastating disease manifested in skeletal muscle by repetitious myonecrosis and regeneration. Because the regenerative process is closely linked to the cumulative severity of muscle damage, which is variably distributed within and between…

Caloric restriction reprograms skeletal muscle molecular pathways in non-human primates: potential relevance to human aging biology

Jayanta Kumar Das; Nirad Banskota; Stefano Donega dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Caloric restriction (CR), achieved by reducing energy intake without malnutrition, has been shown to preserve muscle function and delay age-related declines in strength and mobility by modulating key metabolic and molecular pathways involved in muscle maintenance. While most…

Mechanobiological landscape of muscle stem cells

Kotaro Hirano; Yuji Hara

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Skeletal muscle is distinguished by its remarkable regenerative capacity and mechanical resilience. Continuously challenged by mechanical stress, it adapts to increased load through hypertrophy but undergoes atrophy when mechanical stress is reduced. This regenerative plasticity depends on…

Elizabeth Chen is elected to the U.S. National Academy of Sciences

Robert S. Krauss

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Targeting muscle fibrosis using non-specific collagenase injections destabilizes the basal lamina and induces matrix remodeling

Ross P. Wohlgemuth; Sathvik Sriram; Sarah E. Brashear dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Muscle passive and active function is dependent on the extracellular matrix (ECM). In diseases characterized by muscle fibrosis, namely Duchenne Muscular Dystrophy (DMD), the ECM contributes to deficits in muscle mechanical function and regeneration. Because fibrosis is often…

Duchenne muscular dystrophy: from gene to gene-ius therapies

Antoine Muchir; Antonio Musaro; Jeffrey Chamberlain

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder caused by mutations in the dystrophin gene that result in the absence of functional dystrophin, leading to progressive muscle degeneration, loss of ambulation, respiratory failure, cardiomyopathy, and premature…

Combatting ventilator induced diaphragm dysfunction with human bone marrow mesenchymal stromal cell-derived extracellular vesicles

Ya Wen; Xiang Zhang; Yvette Hedström dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Prolonged mechanical ventilation is closely associated with ventilator-induced lung injury (VILI) and ventilator-induced diaphragm dysfunction (VIDD). These two conditions occur in parallel and contribute to delayed weaning, prolonged intensive care unit (ICU) stay, and poor…

Enhancers integrate microenvironmental signals in muscle stem cells during regeneration in health, disease, and aging

Sarah Hachmer; F. Jeffrey Dilworth

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Effective skeletal muscle regeneration requires muscle stem cells (MuSCs) to continuously interpret and respond to signals from their surrounding microenvironment. These niche-derived cues, including inflammatory, extracellular matrix, paracrine, metabolic, and biomechanical signals…

Declining muscle hyperplasia in juvenile trout is associated with a significant impairment of the supportive function of the myogenic progenitor niche

Sabrina Jagot; Nathalie Sabin; Cécile Rallière dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Unlike mammals and birds, where new muscle fiber formation (hyperplasia) ceases around birth, large and fast-growing fish such as trout undergo a spectacular post-hatching surge of hyperplasia, followed by a considerably delayed hyperplasia decline. This study investigated the…

Insights into the heterogeneous muscle lipidome of dysferlin-deficient mice: effects of age, muscle type, and sex

Stacey N. Keenan; Jackie Bayliss; Olivia Lee dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Dysferlinopathy is an age-dependent muscular dystrophy caused by loss of the membrane-associated protein dysferlin. Disease severity increases with age and selectively affects specific muscle groups, yet the molecular basis for this vulnerability remains unclear. Since lipid remodeling is…

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

Joyce Esposito; Felipe de Souza Leite; Igor Neves Barbosa dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background The progressive skeletal muscle degeneration observed in Duchenne Muscular Dystrophy (DMD) patients requires multiple cycles of satellite cells (SCs) activation to promote tissue regeneration. Dystrophic SCs present intrinsic defects, and the disrupting fibrotic niche hinders…

Senescence dynamics define therapeutic windows for Duchenne muscular dystrophy in DBA/2-mdx mice

Aina Calls-Cobos; Aida Beà Tàrrega; Andrés Cisneros dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Duchenne muscular dystrophy (DMD) is a severe X-linked disorder marked by progressive muscle degeneration and regeneration, inflammation and fibrosis. Cellular senescence has emerged as a potential driver of chronic muscle damage, yet its temporal dynamics and therapeutic…

Stimulation of EGFR signaling in fibro-adipogenic precursors decreases adipogenesis in Duchenne muscular dystrophy

Jules Guillemaud; Georgiana Panci; Aurélie Fessard dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Duchenne Muscular Dystrophy (DMD) is characterized by the formation of fibrosis and fat deposits that progressively replace muscle fibers, resulting in the loss of muscle function. Both fibrosis and adipogenesis are operated by fibroadipogenic precursors (FAPs), but the…

Integrin αVβ5 regulates myoblast proliferation and differentiation in sarcopenia mice treated with FNDC5 gene delivery

Guoxi Gao; Qiyang Wang; Yuqiong Zhang dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Irisin which is encoded by FNDC5 gene, has emerged as a promising therapeutic candidate for alleviating sarcopenia; however, its long-term therapeutic application in muscle regeneration remains insufficiently developed. Methods Our study investigated the potential of FNDC5 gene…

A 3D skeletal muscle system for disease modelling and secretome profiling of Duchenne muscular dystrophy

Mariam Zouhair; Marianna Cosentino; Ludovica Apa dkk.

Skeletal Muscle, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disease characterized by progressive muscle degeneration, exhaustion of the muscle stem cell pool, and extensive fibrotic remodelling, ultimately leading to loss of function and reduced quality of life. Although…