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Cell & Bioscience
Scopus
ISSN 2045-3701 · BMC · 1.562 artikel di indeks
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Artikel Jurnal
The methyltransferase activity of Dot1L is essential for Xenopus tropicalis tadpole development and survival
Abstract Epigenetic modifications of histones play key roles in transcriptional regulation by diverse transcription factors. One such modification is the methylation of histone H3 at lysine 79 (H3K79). The methyltransferase DOT1L is the only known, highly conserved enzyme capable of methylating…
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Artikel Jurnal
Inflammation-induced impairment of synaptic plasticity accelerates atherosclerosis co-depression disease: insights from bioinformatics analysis and transcriptomics
Abstract Background Atherosclerosis (AS) serves as the pathological foundation for numerous cardiovascular and cerebrovascular diseases and is highly comorbid with depression. The mechanisms underlying this co-morbidity are exceptionally complex, posing significant challenges to effective clinical…
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Artikel Jurnal
Targeting epigenetic regulators to boost T cell immunotherapy against cancer
Abstract Epigenetic regulation is crucial in directing T-cell differentiation, function, and fate, thereby influencing the success of T-cell-based immunotherapies. This review begins with an overview of the evolution of T-cell immunotherapies in cancer treatment. We then examine key epigenetic…
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Artikel Jurnal
Fusion oncoproteins orchestrate tumorigenesis and sustain malignant progression via a positive feedback mechanism
Abstract Chromosomal translocations are prevalent genetic events across multiple pediatric cancers, notably in CNS tumors, solid tumors, and leukemias. For decades, Fusion oncoproteins resulting from chromosomal translocations have been proposed as a hallmark of cancers, some of which can drive the…
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Artikel Jurnal
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m6A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response
Abstract Japanese encephalitis virus (JEV), a neurotropic flavivirus, poses a significant public health threat, yet the molecular mechanisms underlying its interaction with host immunity remain poorly understood. This study reveals that zinc finger protein ZNF33B promotes JEV replication by…
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Artikel Jurnal
Anti-seizure potential of J4, an equilibrative nucleoside transporter 1 inhibitor, in a mouse model of tuberous sclerosis complex in response to pentylenetetrazol
Abstract Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder with epileptic seizures caused by genetic mutations in either TSC1 or TSC2 gene. Multiple genetic, epigenetic, and environmental factors can affect the phenotypical outcomes of TSC individuals. Accumulating evidence has…
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Artikel Jurnal
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma
Abstract Background Loss of tumor suppressor Krüpple-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC) is crucial for aggressive tumor progression and poor patient prognosis. However, the mechanisms underlying KLF4 loss in human HCC are poorly characterized. Here, we explore the…
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Artikel Jurnal
IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis
Abstract Background Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses. However, recent evidence suggests that these diseases may share overlapping immune mechanisms, especially concerning keratinocyte…
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Artikel Jurnal
Maternal hyperhomocysteinemia induces fetal growth restriction by suppressing angiogenesis at the maternal-fetal interface
Abstract Maternal hyperhomocysteinemia (HHcy) is closely linked to fetal growth restriction (FGR), yet the underlying mechanisms remain incompletely understood. In this study, we established a rat model of HHcy by administering a high-methionine diet during pregnancy and confirmed the presence of…
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Artikel Jurnal
The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair
Abstract Background Resistance to chemotherapy drugs is one of the significant factors for limited treatment options and poor prognosis in esophageal cancer. A study has found that SOX12 plays a role in cisplatin resistance in hepatocellular carcinoma cells, but the function and mechanism of SOX12…
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Artikel Jurnal
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice
Abstract Aims/hypothesis Metabolic dysfunction–associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease globally and is closely associated with type 2 diabetes (T2D) and obesity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) offer partial therapeutic benefits in…
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Artikel Jurnal
Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila
Abstract Most neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis. However, the regulation of the NSC maintenance during brain development is not well understood…
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Artikel Jurnal
In vitro mimicking of humanized cardiogenesis under porcine condition
Abstract Background One promising strategy to generate humanized organs is through embryo complementation by injecting human pluripotent stem cells (PSCs) into gene-edited porcine embryos. This strategy is predicated on how human cells adapt to a porcine environment, which has a body temperature of…
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Artikel Jurnal
α-Synuclein triggers intercellular nanotubes formation to prevent apoptosis in astroglia by promoting stemness
Abstract Astrocytes play a significant role in neuroprotection by internalizing neurodegenerative aggregates and facilitating their degradation. Recent studies indicate that α-Synuclein (α-SYN) protofibrils promote the transfer of pathogenic aggregates and dysfunctional mitochondria between…
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Artikel Jurnal
Dual repression modes triggered by constitutively stabilized beta-catenin in the dorsal neural tube underlie cell fate alterations of the roof plate, neural crest, and dorsal interneurons
Abstract The roof plate that covers the dorsal neural tube is a key organizer or signaling center that generates morphogenetic signaling proteins to regulate neural crest cell production and dorsal CNS patterning. However, knowledge remains limited regarding the molecular mechanism regulating roof…
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Artikel Jurnal
The ubiquitin E3 ligase TRIM59 in myeloid cell regulates complement C3 through degrading CCAAT/enhancer binding protein β to promote neuron survival after ischemic stroke
Abstract Background Ischemic stroke is a cerebrovascular disease that activates the complement system, leading to inflammation and neuronal injury. TRIM59, an E3 ubiquitin ligase, has been extensively studied in cancer, sepsis, and myocardial infarction, and is upregulated in macrophages after…
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Artikel Jurnal
SIAH2-EPHB6 axis enhances filopodia formation in hepatocellular carcinoma cells by regulating RHOF
Abstract Seven in absentia homologue 2 (SIAH2) has been shown to contribute to the progression of various human tumors, including hepatocellular carcinoma (HCC). However, the precise mechanisms by which SIAH2 promotes HCC cell migration remain to be fully elucidated. In this study, we demonstrate…
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Artikel Jurnal
Lactate metabolic reprogramming and lactylation modification: molecular mechanisms reshaping the tumor immunosuppressive microenvironment
Abstract The immunosuppressive tumor microenvironment (TME) remains a major therapeutic challenge in oncology. This immunosuppression arises through two synergistic mechanisms: impaired cytotoxic function of T cells and NK cells, and differentiation of immune cells into immunosuppressive subtypes…
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