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Clinical and Translational Allergy
Scopus
ISSN 2045-7022 · Wiley · 951 artikel di indeks
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Artikel Jurnal
Association Between the Angioedema Control Test and Attack Frequency in Hereditary Angioedema
ABSTRACT Background Hereditary angioedema (HAE), defined by unpredictable, painful, acute swelling attacks affecting several bodily locations, diminishes patients' quality of life. Assessing disease activity, burden, and treatment response pose challenges in routine care. The patient‐reported…
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Artikel Jurnal
T Cell/Mast Cell Crosstalk in the Skin of Patients Suffering From Immune‐Mediated Diseases, Focusing on Chronic Spontaneous Urticaria
ABSTRACT The crosstalk between immune cells in skin lesions of numerous immune‐mediated diseases such as atopic dermatitis, psoriasis and other T cell mediated is fundamental for understanding the pathogenesis and treating these diseases. The mechanisms by which most activated immune cells such as…
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Artikel Jurnal
Serum Haptoglobin as a Predictor of Treatment Response in Patients With Chronic Spontaneous Urticaria
ABSTRACT Background Chronic spontaneous urticaria (CSU) is a mast cell‐driven disease associated with systemic inflammation and altered immune responses. Haptoglobin (HP), an acute‐phase glycoprotein, exhibits antioxidative and immunomodulatory properties, while zonulin, the precursor of HP‐2…
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Artikel Jurnal
Real‐World Effectiveness of Mepolizumab in Patients With Chronic Rhinosinusitis With Nasal Polyps: Findings From the European CRS Outcome Registry (CHRINOSOR)
ABSTRACT Background The SYNAPSE phase 3 study demonstrated that mepolizumab significantly improves nasal polyp score (NPS), quality of life and symptom severity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Objective We aimed to evaluate mepolizumab effectiveness in a…
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Artikel Jurnal
Importance of Smell Loss to Patients With Chronic Rhinosinusitis With Nasal Polyps: Options for Management and Recovery
ABSTRACT Primary diffuse type 2‐dominant chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nasal cavity and paranasal sinuses associated with significant morbidity. Impaired sense of smell is a cardinal symptom of CRSwNP and one of the most burdensome for patients…
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Artikel Jurnal
Food Allergy Diagnosis in Early Childhood: Journey Mapping Study With Parents and Pediatricians
ABSTRACT Food allergy (FA) in early childhood can be challenging for families, even before a diagnosis is made, as parents often experience anxiety and have to change their routines. Research integrating parental and pediatrician perspectives during the pre‐diagnostic phase is scarce. This study…
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Artikel Jurnal
Real‐Life Safety of Japanese Cedar Pollen Sublingual Immunotherapy Tablets: A Post‐Marketing Survey
ABSTRACT Background Japanese cedar (JC) pollen sublingual immunotherapy (SLIT)‐tablets (5000 Japanese allergy units [JAU]) are licensed for the treatment of JC‐pollinosis with no age restriction on the basis of the results of a 5‐year clinical trial. However, there have been no large‐scale surveys…
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Artikel Jurnal
Adult‐Onset Compared to Childhood‐Onset Asthma: Multifaceted Symptoms, Comorbidity, and Healthcare Burden
ABSTRACT In this study, we compared symptoms, comorbidities, and healthcare burden between childhood‐onset asthma (
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Artikel Jurnal
Real‐World Efficacy and Systemic Immune Modulation Upon Tralokinumab Treatment in Atopic Dermatitis
ABSTRACT Background Tralokinumab, an interleukin‐13 (IL‐13) monoclonal antibody, has shown clinical efficacy in randomized trials for moderate‐to‐severe atopic dermatitis (AD). This study aims to evaluate clinical and immunological outcome upon tralokinumab treatment in a real‐world cohort of…
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Artikel Jurnal
Use of Artificial Intelligence‐Based Platforms to Support Searches in Evidence Synthesis Studies: A Study of the EAACI Methodology Committee
ABSTRACT Objective To demonstrate an evaluation of the use of artificial intelligence (AI) in supporting tasks in evidence synthesis (particularly search for primary studies) in the allergy or respirology fields. Methods We queried three AI‐based platforms specialised on identifying scientific…
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Artikel Jurnal
Phenotypic Clusters of Severe Asthma and Response to Dupilumab in Real‐World Practice
ABSTRACT Background Severe asthma is a heterogeneous disease with variable clinical and inflammatory profiles that may influence responses to biological therapies. Identifying phenotypic clusters may help optimize patient selection and treatment outcomes. Objective To identify phenotypic clusters…
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Artikel Jurnal
CCR2/CCR5 Signaling Defines a Pathogenic Interstitial Macrophage Subset That Drives Severe Asthma
ABSTRACT Background Severe asthma is a chronic inflammatory disease characterised by airway dysfunction, persistent immune activation and corticosteroid resistance. While macrophages are key regulators of lung immunity, how individual subsets, particularly interstitial macrophages (IMs), contribute…
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Artikel Jurnal
Longitudinal Proteomic Signatures of Dupilumab and Tralokinumab Treated Atopic Dermatitis Patients
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory disease driven by Type 2 (Th2) inflammation. Dupilumab (anti‐IL‐4Rα) and tralokinumab (anti‐IL‐13) are effective biologic therapies, but a direct comparison of their longitudinal effects on the systemic proteome is lacking. This…
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Artikel Jurnal
Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab
ABSTRACT Background In Western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is predominantly associated with a type 2 inflammatory endotype. While nasal secretion analysis shows promise for disease endotyping, current biomarkers remain limited for accurate stratification, disease…
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Artikel Jurnal
Performance of PEN‐FAST and CEPH‐FAST for Cephalosporin Allergy Delabeling
ABSTRACT Background Unverified antibiotic allergy labels lead to suboptimal antimicrobial prescribing and increased antibiotic resistance. Cephalosporins are among the most frequently administered antibiotics and cephalosporin allergy labels increasingly limit optimal therapy. Clinical decision…