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Cancer Medicine
Scopus
ISSN 2045-7634 · Wiley · 7,856 articles in the index
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Journal Article
Distinct Molecular and Prognostic Profiles of Left‐ and Right‐Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations
ABSTRACT Background Colorectal cancer (CRC) isthe third most common cancer and the second leading cause of cancer‐relateddeath worldwide. Its genetic heterogeneity complicates treatment. This studyaimed to compare clinicopathological, molecular, and prognostic factors betweenleft‐sided (LCC) and…
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Journal Article
Racial and Ethnic Disparities in Pharmacologic and Non‐Pharmacologic Pain Management Among Older Cancer Survivors
ABSTRACT Introduction Pain is common among cancer survivors and often managed with medication; however, racial‐ethnic disparities persist in pain treatment. Given inadequate data on pharmacologic and non‐pharmacologic pain management among minoritized cancer survivors, we investigated these…
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Journal Article
Emergence of BRCA Reversion Mutations in Prostate Cancer Prior to PARP Inhibitor Exposure: Clinical and Therapeutic Implications
ABSTRACT Background Inactivating BRCA1/2 mutations confer sensitivity to poly(ADP‐ribose) polymerase inhibitors (PARPi) in prostate cancer (PCA). However, secondary BRCA1/2 reversion mutations (BRCArev) can restore BRCA function and mediate acquired PARPi resistance. While BRCArev typically arise…
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Journal Article
Clinical and Echocardiographic Insights Into Right Heart Masses: A Retrospective Study in China (2010–2023)
ABSTRACT Background This study aimed to analyze the clinical and echocardiographic characteristics, pathological profiles, and outcomes of right heart masses, and to explore the role of echocardiography in the evaluation of these masses. Methods We retrospectively analyzed 171 patients with…
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Journal Article
Plasma Fibrinogen Predicts Response to Immune Checkpoint Inhibitor by Inflammatory Tumor Microenvironment in Esophageal Cancer
ABSTRACT Background Plasma fibrinogen (FNG) is a prognostic marker in esophageal squamous cell carcinoma (ESCC). However, its predictive value for immune checkpoint inhibitor (ICI) efficacy and the underlying mechanisms remain unclear. This study aimed to evaluate the clinical significance of…
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Journal Article
Rising Incidence of Tongue Cancer Surgeries Among Middle‐Aged and Older Women in Japan: A Nationwide Claims‐Based Analysis From 2014 to 2022
ABSTRACT Background This study investigated recent trends and demographic patterns in tongue cancer surgeries in Japan using nationwide insurance claims data. Methods Annual surgery counts and rates (per 100,000 person‐years) were analyzed using medical (2014–2022) and dental (2016–2022) claims…
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Journal Article
Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation‐Induced Lymphopenia
ABSTRACT Background The spleen dose‐volume threshold for lymphopenia in abdominal radiotherapy has not yet reached a consensus. Our previous research indicated a correlation between these factors, but the threshold has not been determined. Therefore, we investigated the dynamic changes in…
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Journal Article
Survival Benefit and Safety of Anatomic Resection in Cirrhotic Hepatocellular Carcinoma: Propensity‐Matched Analysis of 1699 Patients
ABSTRACT Background The efficacy of anatomic resection (AR) versus non‐anatomic resection (NAR) for hepatocellular carcinoma (HCC) remains controversial, particularly among patients with differing underlying liver conditions. This study aimed to compare the outcomes of AR and NAR in HCC patients…
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Journal Article
Clinical Significance and Therapeutic Potential of Long Non‐Coding RNA H19 in Soft Tissue Sarcoma
ABSTRACT Background Long non‐coding RNA (lncRNA) H19 plays a pivotal role in the pathogenesis of different human cancers, but its role in soft tissue sarcoma (STS) has not yet been defined. Methods We analyzed H19 expression patterns in various cancer cell lines, focusing on sarcoma subtypes. RNA…
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Journal Article
Neoadjuvant Chemotherapy Versus Primary Cytoreductive Surgery for Metastatic Endometrial Cancer
ABSTRACT Objective To evaluate the pattern of use and clinical outcomes associated with neoadjuvant chemotherapy (NACT) compared with primary debulking surgery (PDS) in patients with stage IV endometrial cancer. Methods We utilized the National Cancer Database to identify individuals diagnosed with…
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Journal Article
Risk of Type II Diabetes Mellitus Among B‐Cell Non‐Hodgkin's Lymphoma Survivors
ABSTRACT Purpose Advancing therapies have increased B‐cell Non‐Hodgkin's Lymphoma (B‐NHL) patient survival. However, data are limited on the risk of type II diabetes mellitus (type II DM) in adult survivors following treatment. This study examines the risk of type II DM among a Utah population of…
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Journal Article
The Effects of Bone‐Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX)
ABSTRACT Introduction Renal cell carcinoma (RCC) is the most common renal malignancy—bone metastases (BM) are indicative of aggressive disease with a poor prognosis. We aim to evaluate the overall mortality of patients with RCC with and without BM, and to elucidate the effects of bone‐remodeling…
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Journal Article
SULF1 in Cancer Associated Fibroblasts Promotes Invasion in Head and Neck Cancer Cell Lines
ABSTRACT Background Cancer‐associated fibroblasts (CAFs) significantly influence tumor behavior in head and neck squamous cell carcinoma (HNSCC) and other malignancies. We identified the extracellular sulfatase SULF1 as a key stromal factor highly expressed in CAFs and associated with poor…
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Journal Article
A Retrospective Study on the Clinicopathological Characteristics and Prognostic Analysis of Gynecologic Neuroendocrine Carcinoma
ABSTRACT Background Gynecologic neuroendocrine carcinomas (NECs) are rare, highly aggressive malignancies with early metastatic potential and limited evidence to guide optimal management across different primary sites. Aims To characterize the clinicopathological features, treatment patterns…
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Journal Article
Trends in Survival and Cure Indicators of Thin and Thick Cutaneous Malignant Melanoma in Italy
ABSTRACT Background In Italy, cure indicators of cutaneous malignant melanoma according to Breslow tumour thickness have never been assessed. Objectives To evaluate the time trend in 1‐year net survival (NS), 5|1‐year conditional NS (CNS) and cure fraction (CF). Methods Data from 10 cancer…
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Journal Article
Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen‐Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
ABSTRACT Background Reactive oxygen species (ROS) can induce cancer cell apoptosis, which plays a crucial role in breast cancer therapy. Carnosic acid (CA) exerts an anti‐tumor effect via generating ROS or activating the mitochondria‐related apoptosis pathway in vitro and in vivo. The deoxy‐glucose…
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Journal Article
The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications
ABSTRACT Objectives MET aberrations are capable of triggering oncogenesis through multiple clinical significance genomic alterations. In non‐small cell lung cancer, MET exon 14 skipping and MET amplification confer sensitivity to MET tyrosine kinase inhibitors. The MET gene is also one of the…
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Journal Article
Positive Association Between Body Mass Index and the Likelihood of Reporting an Overall Cancer Diagnosis Among College Students in the United States
ABSTRACT Introduction We conducted the first epidemiologic study to examine the dose–response relationship between body mass index (BMI) and the likelihood of reporting an overall cancer diagnosis, along with the association between overweight or obese and cancer diagnosis among college students in…
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Journal Article
A Novel MPT‐Driven Necrosis‐Related lncRNA Signature for Prognostic Prediction in Hepatocellular Carcinoma: Validation Using Organoids
ABSTRACT Background Mitochondrial permeability transition (MPT)‐driven necrosis, a recently identified form of programmed cell death, significantly influences tumor progression, therapy response, and prognosis. However, research on mitochondrial permeability transition‐driven necrosis‐related long…
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Journal Article
Prognostic Factors and Nomogram‐Based Prediction Models for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis Undergoing Cytoreductive Surgery: A Retrospective Cohort Study
ABSTRACT Background Colorectal cancer (CRC) with synchronous peritoneal metastasis (SPM) presents poor prognosis and complex treatment challenges. This study aimed to identify independent prognostic factors and develop nomogram‐based prediction models for overall survival (OS) and progression‐free…
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