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Fluids and Barriers of the CNS
Scopus
ISSN 2045-8118 · BMC · 852 artikel di indeks
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Artikel Jurnal
Histone and non-histone (de)acetylation impact on the blood-brain barrier
Abstract Background The blood-brain barrier (BBB) ensures the homeostasis of the central nervous system by regulating the composition of the brain interstitial fluid, required for proper brain function. Nonetheless, its properties are dynamic and susceptible to the influence of environmental…
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Artikel Jurnal
Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease
Abstract Background With the progression of late-onset Alzheimer disease (LOAD), there is a dysregulation and then a breakdown of the blood-brain barrier (BBB). An important pathological feature in the brains of patients is the accumulation of amyloid beta (Aβ) peptides. Their aggregation leads to…
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Artikel Jurnal
IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells
Abstract Background IIIG9 was originally identified as a novel regulatory subunit of protein phosphatase 1 (PP1, PPP1R32) in ependymal cells, where it localizes to cilia and adherens junctions. However, it remains unclear whether IIIG9 forms complexes with PP1α, β, or γ to regulate ciliary function…
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Artikel Jurnal
A novel method of fabricating dynamic, heterogenous benchtop lateral and third ventricle phantoms from MRI of hydrocephalus patients: a verification and validation study
Abstract Background Investigation of the failure of shunts used to treat hydrocephalus has been a topic of research for several decades, though it is difficult to understand the role of heterogeneous patient ventriculomegaly shifts over time. In this work, we present the design, verification, and…
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Artikel Jurnal
MicroRNA210 regulated brain pericyte dysfunction exacerbates hypoxic-ischemic brain injury in neonatal mice
Abstract Background While the role of pericytes in blood-brain barrier (BBB) disruption and neuroinflammation is well-established in adult neurological disorders, their contribution to neonatal brain injury is largely unexplored. Here, we investigated the role of brain pericytes in hypoxic-ischemic…
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Artikel Jurnal
Neurovascular and metabolic dysfunction with cell type-specific transcriptomic changes in presymptomatic 5XFAD mice
Abstract Background Altered cerebral metabolism and blood-brain barrier (BBB) dysfunction are increasingly recognized as key contributors to the preclinical phase of Alzheimer’s disease (AD), highlighting their importance in early pathogenesis. Sensitive biomarkers that precede irreversible…
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Artikel Jurnal
Inflammatory protein profiles and shunt response in iNPH
Abstract Introduction Neuroinflammation in the context of idiopathic normal pressure hydrocephalus (iNPH) is poorly studied. Currently, no single objective test can reliably predict outcomes after shunt surgery. The aim was to investigate whether neuroinflammatory proteins in cerebrospinal fluid…
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Artikel Jurnal
Modeling neurovascular dysfunction in Alzheimer’s disease using an isogenic brain-chip model
Abstract Background The pathology of Alzheimer’s Disease (AD) is characterized by aggregates of amyloid beta (Aβ) peptides and neurofibrillary tau tangles. Increased blood-brain barrier (BBB) permeability and reduced Aβ clearance, which signal neurovascular dysfunction, have also been proposed as…
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Artikel Jurnal
Notch signaling activation reduces vesicular endocytosis in human pluripotent stem cell-derived CNS-like endothelial cells
Abstract Background Mechanisms guiding the induction of blood-brain barrier (BBB) properties in central nervous system (CNS) endothelial cells during human development are incompletely understood. For example, there is a limited understanding of signaling pathways that influence the unique property…
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Artikel Jurnal
Bridging the blood-brain barrier: strategies to improve delivery of biologics to tumors in the brain
Abstract The unique anatomical and physiological features of the blood-brain barrier (BBB), while essential for maintenance of normal brain health, present significant challenges in development of effective therapies for neurological disorders from a drug delivery perspective. This is particularly…
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Artikel Jurnal
Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain
Abstract Background Dynamic contrast-enhanced MRI has become an invaluable tool for mapping cerebrospinal fluid (CSF) flow and delineating solute transport pathways in the brain. However, the influence of experimental parameters, including infusion location, infusion rate, and anesthetic regimen…
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Artikel Jurnal
Estimation of metabolic water production in human and rat brain and spinal cord
Abstract Background Cerebrospinal fluid (CSF) is vital to maintain brain homeostasis by facilitating waste removal, nutrient transport, and regulation of intracranial pressure. The choroid plexus is generally assigned as the primary source of CSF secretion, but it remains unresolved to what extent…
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Artikel Jurnal
The impact of human brain geometry on the transport of an intrathecal tracer
Abstract Background Intrathecal contrast-enhanced magnetic resonance imaging (MRI), utilizing the contrast agent gadobutrol as cerebrospinal fluid (CSF) tracer is emerging as a useful method to study glymphatic function in the human brain. A consistent finding with this technique is large…
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Artikel Jurnal
Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow
Abstract The blood vessels of the central nervous (CNS) system form a tight, protective blood-brain barrier (BBB). This barrier is essential for healthy CNS function but also poses a hurdle in the treatment of increasingly common neurological disorders. Additionally, BBB dysfunction is a hallmark…
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Artikel Jurnal
Assessment of patients affected by INPH after external lumbar drainage: what is the better timing?
Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological condition characterized by cerebrospinal fluid (CSF) accumulation contributing to clinical symptoms. Removal of excess CSF can lead to improvement, and among the available approaches…
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Artikel Jurnal
Translational applicability of human blood-brain barrier spheroid models for the development of brain-penetrant therapeutic antibodies
Abstract Drug delivery systems play a key role in the development of new therapeutic strategies for brain diseases. Antibodies capable of crossing the blood–brain barrier (BBB) have attracted considerable attention as promising drug carriers. To facilitate their development, we previously…
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Artikel Jurnal
The impact of chronic and acute sleep deprivation on key Alzheimer’s disease biomarkers: a systematic review and meta-analysis
Abstract Background Sleep disruption is recognized as a risk factor for Alzheimer’s disease (AD). Both chronic and acute sleep deprivation (SD) may increase cerebrospinal fluid (CSF) levels of amyloid-beta (Aβ) and tau, potentially complicating early AD diagnoses. Some studies also suggest an…
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Artikel Jurnal
Evaluation of shunt valve flow dynamics in series
Abstract Background and purpose Dysregulation of cerebrospinal fluid (CSF) volume results in hydrocephalus, a disease that leads to over 30,000 surgical shunt-valve implantations annually in the US. These shunt-valves require a trial-and-error process to determine optimal settings for each…