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Open Biology
Scopus
ISSN 2046-2441 · The Royal Society · 1,570 articles in the index
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A luminal proteome of the endoplasmic reticulum and Golgi apparatus reveals a novel modulator of ER stress tolerance in African trypanosomesA luminal proteome of the endoplasmic reticulum and Golgi apparatus reveals a novel modulator of ER stress tolerance in African trypanosomes
AbstractAfrican trypanosomes employ specialized mechanisms of membrane trafficking as a strategy to persist in both the mammalian host and insect vector. Their survival relies on continuous synthesis and surface delivery of extremely abundant surface coat proteins, imposing an extraordinary…
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Interaction of genetic and environmental risk factors in the aetiology of keratoconusInteraction of genetic and environmental risk factors in the aetiology of keratoconus
AbstractKeratoconus (KC) is a multifactorial corneal ectasia disorder that is influenced by genetic and environmental risk factors. The manner and degree to which any risk factor contributes mechanistically to KC pathogenesis is not fully understood, despite epidemiological associations. Likewise…
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Structural basis of Drosophila insulin receptor activation by DILP2 hormoneStructural basis of Drosophila insulin receptor activation by DILP2 hormone
AbstractInsulin-related hormones regulate key life processes in the animal kingdom, from metabolism to growth, lifespan and ageing, through an evolutionarily conserved insulin and insulin-like hormones signalling axis (IIS). In humans, the IIS axis is controlled by insulin, two insulin-like growth…
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A CDCA2–MYC positive feedback loop controls cancer cells survival
AbstractCellular myelocytomatosis oncogene (MYC) transcription factors are encoded by a family of genes that include the prototype member MYC, MYCN and MYCL, and most human cancers display expression alterations of MYC genes. MYC is regulated at multiple levels, and its stability and activity are…
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Pan-resistome and genomic plasticity analysis of antibiotic resistance in Aeromonas: new vaccine targets for A. caviae, A. veronii and A. hydrophila through reverse vaccinology
AbstractAeromonas species are globally significant pathogens. However, the mechanisms driving their antimicrobial resistance patterns remain unclear. This study addresses the spread of resistance genes in the Aeromonas genus through a large-scale genomic analysis of all complete Aeromonas genomes…
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The evolution and functional significance of neuropeptide cocktails: insights from SALMFamides in asteroid echinodermsThe evolution and functional significance of neuropeptide cocktails: insights from SALMFamides in asteroid echinoderms
AbstractNeuropeptides derived from larger precursor proteins are neuronal signalling molecules that regulate physiological processes and behaviour. Some precursors, particularly in invertebrates, give rise to ‘cocktails’ of structurally related neuropeptides, but the functional significance of this…
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The periosteum as an endocrine organ: historical foundations and new insightsThe periosteum as an endocrine organ: historical foundations and new insights
AbstractAnatomists have recognized the periosteum as essential for bone growth and repair, and yet its broader physiological roles have remained underappreciated. Emerging evidence now positions the periosteum not only as a structural membrane, but also as a dynamic interface that integrates…
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tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations
AbstracttRNA modifications are central to bacterial translational control. Here, we integrated genetics, mass spectrometry, epitranscriptomics and comparative genomics to map the tRNA modification genes of the Gram-positive pathogens Streptococcus mutans and Streptococcus pneumoniae. Both species…
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NudC moonlights in ribosome biogenesis and homeostasis in polyploid cells of Drosophila melanogasterNudC moonlights in ribosome biogenesis and homeostasis in polyploid cells of Drosophila melanogaster
AbstractRibosomes, the cellular machinery responsible for protein synthesis, are fundamental across all kingdoms of life. Disruption of ribosome biogenesis (RiBi) can cause severe ribosomopathies, underscoring the need for precise regulatory mechanisms. In this study, we identified a role for the…
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Emerging role for R-loops in chromosome segregationEmerging role for R-loops in chromosome segregation
AbstractR-loops are evolutionarily conserved three-stranded nucleic acid structures formed when a nascent RNA transcript hybridizes with its complementary DNA strand, thereby exposing the non-template strand as single-stranded DNA. Traditionally viewed as a by-product of transcription, R-loops are…
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Assessment of adult structural plasticity in Drosophila neuronsAssessment of adult structural plasticity in Drosophila neurons
AbstractUnravelling how adult neurons reshape their architecture is key to understanding post-developmental plasticity. Drosophila clock neurons, which remodel their terminals on a daily basis, offer a unique model to examine the mechanisms underlying structural plasticity. In this study, we…
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Molecular basis and therapeutic potential of sortase A inhibitors as new antibiotics against MDR pathogensMolecular basis and therapeutic potential of sortase A inhibitors as new antibiotics against MDR pathogens
AbstractAttaching proteins to the cell surface presents a technical challenge to Gram-positive bacteria. A class of enzymes called sortases solves this challenge by covalently anchoring proteins, including an arsenal of virulence factors, to the cell wall. Most Gram-positive bacteria have multiple…
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Parental rearing shapes brain functional networks and socio-sexual behaviours in the prairie vole
Abstract Animal models with natural variation in family structure, like the prairie vole (Microtus ochrogaster), offer valuable insight into how parental care shapes offspring behaviour. While prior studies have linked early care to long-term behavioural outcomes, the underlying brain network…
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Structural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaPStructural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaP
AbstractHost–pathogen interactions frequently depend on key components of the bacterial cell surface, such as capsules and lipopolysaccharides in Gram-negative bacteria. The first step in the synthesis of lipid-linked polysaccharides is the substitution of a uridine diphosphate (UDP)-sugar by a…
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A modern toolbox to elucidate the role of the human microbiome in modulating mycobacterial gut infectionsA modern toolbox to elucidate the role of the human microbiome in modulating mycobacterial gut infections
AbstractInflammatory bowel diseases (IBDs) are a major public and veterinary health concern, but the causes are poorly understood. In this review, we discuss the potential of mycobacteria as causative factors for such diseases. We focus on similarities between the most common human IBD, Crohn's…
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CDK1-Cyclin B mediated phosphorylation of PP2A-B56 on B56Par1.T73T75 controls mitotic entry timing and Schizosaccharomyces pombe cell sizeCDK1-Cyclin B mediated phosphorylation of PP2A-B56 on B56Par1.T73T75 controls mitotic entry timing and Schizosaccharomyces pombe cell size
AbstractMitosis is triggered when the rising activity of CDK1-Cyclin B, amplified by the CDK1/Cdc25/Wee1 feedback loop, overcomes inhibitory signalling from Wee1 and counteracting phosphatases. CDK-opposing phosphatases PP1, PP2A-B55 and PP2A-B56 are regulators of mitosis. A screen for…
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Contribution of mechanical forces in multiciliated cell differentiationContribution of mechanical forces in multiciliated cell differentiation
AbstractMulticiliated cells, through the coordinated beating of motile cilia, are vital for moving fluids in the brain and mucus in the airways and in the reproductive organs. Their dysfunction leads to diseases, associated with chronic airway infections, subfertility and ventricular enlargement. A…
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Challenges and opportunities in type III secretion system effector predictionChallenges and opportunities in type III secretion system effector prediction
AbstractType III secretion system effectors (T3SEs) are small bacterial proteins with big biological roles. They act as central molecular mediators of interactions between Gram-negative bacteria and eukaryotic hosts, spanning pathogenic, symbiotic and environmental contexts. Over the past three…
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