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Translational Neurodegeneration
Scopus
ISSN 2047-9158 · BMC · 536 artikel di indeks
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Artikel Jurnal
Mapping cellular vulnerability in Parkinson’s disease using retro-AAVs and preformed α-synuclein fibrils
Abstract Background Parkinson disease (PD) is characterized by progressive neuronal loss within defined brain regions, accompanied by α-synuclein (αSyn)-rich inclusions, termed Lewy pathology (LP). However, it is unclear which cellular factors render certain neuronal populations vulnerable, while…
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Artikel Jurnal
Proximity labeling in neuroscience: decoding molecular landscapes for precision neurology
Abstract The intricate cellular architecture and dynamic molecular interplay in the nervous system have long challenged mechanistic studies of neurological diseases. Conventional approaches often miss the transient, low-affinity, or spatially confined interactions that underlie neural homeostasis…
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Artikel Jurnal
Implications of virus-induced stress granules in tauopathies
Abstract Tauopathies are characterized by aberrant tau structure and function, which is associated with neurodegenerative dementias, such as Alzheimer’s disease, Pick’s disease, and frontotemporal dementia, as well as the motor neuron disease amyotrophic lateral sclerosis. Consistent association of…
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Artikel Jurnal
Mitochondrial DNA: a molecular switch driving sterile neuroinflammation
Abstract Mitochondrial DNA (mtDNA) plays a pivotal role in the regulation of neuroinflammation, acting as a potent trigger of innate immune responses when released into the cytoplasm or extracellular space. mtDNA is structurally similar to bacterial DNA, containing unmethylated CpG motifs that are…
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Artikel Jurnal
Microbiota and Alzheimer’s disease: mechanistic insights from a multi-organ perspective
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder driven by multifactorial mechanisms. Increasing evidence suggests that dysbiosis, a term denoting an imbalance in the composition of the microbiota, may play a pivotal role in the pathogenesis of AD across multiple bodily…
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Artikel Jurnal
Brain region-resolved pharmacodynamics of an antisense oligonucleotide targeting human SNCA 3′UTR in BAC-hSNCA rats
Abstract Background Alpha-synuclein accumulation contributes to Parkinson’s disease (PD), and lowering α-synuclein expression is a candidate disease-modifying approach. The brain-wide pharmacodynamic profile of human-targeting antisense oligonucleotides (ASOs) remains incompletely defined in…
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Artikel Jurnal
What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review
Abstract The degenerating motor neurons of amyotrophic lateral sclerosis (ALS) patients are characterized by the accumulation of cytoplasmic aggregates, specifically enriched in ubiquitinated TDP-43. Expressed mainly in the nucleus and partially in the cytoplasm to execute its role in RNA…
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Artikel Jurnal
Species-dependent activities of the PINK1–parkin axis
Abstract In vitro studies have established that PTEN-induced putative kinase 1 (PINK1) and parkin are central regulators of mitophagy, and loss-of-function mutations in either gene can cause early-onset Parkinson’s disease (PD). Although various animal models, including mice and pigs with PINK1 or…
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Artikel Jurnal
Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration
Abstract Background Extensive research evidence indicates that neuronal immune receptors play a critical role in Alzheimer's disease (AD). However, it remains unclear how these receptors convert extracellular signals into cellular pathological changes. Proteolytic cleavage of membrane receptors…
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Artikel Jurnal
From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson’s disease
Abstract The definition of Parkinson’s disease (PD) is undergoing a profound transformation from a “clinical syndrome” to a “biological entity”, with development of two objective biological classification systems, the NSD-ISS (Neuronal Alpha-Synuclein Disease Integrated Staging System) and the…
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Artikel Jurnal
Ketogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges
Abstract The ketogenic diet (KD) is increasingly recognized as a promising therapeutic strategy for neurodegenerative disorders because of its multifaceted impacts on key pathophysiological mechanisms. This review explores the molecular pathways through which KD may protect against…
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Artikel Jurnal
Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD
Abstract Background Accumulation of Annexin A11 (ANXA11) aggregates is a distinct pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While genetic studies have linked ANXA11 mutations (e.g., D40G) to disease, the precise molecular events…
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Artikel Jurnal
Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy
Abstract Astrocytes, the most abundant glial cells in the central nervous system, play increasingly recognized roles in metabolic regulation beyond their classical supportive functions. This review summarizes current understanding of astrocyte morphological and molecular heterogeneity, with…
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Artikel Jurnal
Human amniotic mesenchymal stromal cell-derived extracellular vesicles reprogram microglia and prevent neurodegeneration in experimental models of Alzheimer’s disease
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and disproportionately affects women, with neuroinflammation emerging as a key driver of disease onset and progression. Beyond amyloid-β (Aβ) and hyperphosphorylated tau protein accumulation, chronic…
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Artikel Jurnal
Phase separation in neurodegenerative disorders: a metabolic perspective on protein aggregation and therapeutic targeting
Abstract Biomolecular condensates formed via liquid–liquid phase separation (LLPS) are increasingly recognised as dynamic organisers of intracellular biochemistry, particularly in neurons where spatially restricted signalling, RNA metabolism, and proteostasis are essential. Aberrant phase…
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Artikel Jurnal
Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases
Abstract The brain was long been regarded as an immune-privileged organ with a lack of lymphatic drainage, partly because of the absence of parenchymal lymphatic vessels. This long-held doctrine has been challenged by recent advancements in central lymphatic vascular biology. The central drainage…
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Artikel Jurnal
The gut neuroepithelial unit as a neurodegeneration-relevant interface in the gut–brain axis
Abstract Neurodegenerative diseases are increasingly linked to abnormalities in the gut–brain axis, yet the local intestinal interface at which luminal and mucosal perturbations are related with the central nervous system remains poorly defined. The gut neuroepithelial unit (GNU) is proposed as a…
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Artikel Jurnal
Calbindin-D28k deficiency mediates tau-driven hippocampal hyperexcitement and cognitive impairment
Abstract Background Medial temporal lobe hyperexcitation or seizures originating from the hippocampus are frequently observed in Alzheimer's disease (AD) patients, contributing to accelerated cognitive decline. As the hippocampus is an early vulnerable area of tau pathology, the mechanisms by which…
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Artikel Jurnal
Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington’s disease
Abstract Background Huntington’s disease (HD) is a genetically dominant neurodegenerative disorder characterized by several pathological mechanisms, including the disruption of brain cholesterol homeostasis. In several HD animal models, brain cholesterol biosynthesis and levels are reduced. Since…