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International Journal of Oral Science
Scopus
ISSN 2049-3169 · Nature Publishing Group · 378 artikel di indeks
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Artikel Jurnal
Expert consensus on the diagnosis and management of tooth developmental anomalies
Abstract Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process, resulting in abnormalities in tooth number, structure, and morphology. These anomalies typically manifest during childhood, impairing dental function, maxillofacial…
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Artikel Jurnal
The YTHDC1-m6A-GADD45B axis promotes chondrogenesis of hPDLSCs via suppressing senescence through p53/p21 signalling pathway
Abstract Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with limited therapeutic options. Stem cell-based tissue engineering, particularly utilizing human periodontal ligament stem cells (hPDLSCs), represents a promising approach for cartilage regeneration. However, we…
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Artikel Jurnal
Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder
Abstract Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive degenerative disease in which the intricate mechanisms of the condyle cartilage damage are yet to be disclosed. A detailed characterization of cellular composition and signal networks involved in the pathogenesis is in…
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Artikel Jurnal
DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries
Abstract Early childhood caries is a form of tooth decay in children under the age of 6 and impacts more than 514 million children worldwide. Severe early childhood caries (S-ECC) represents the most advanced and aggressive form of early childhood caries, defined by an age-dependent number of…
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ANKRD1 sustains a neurogenic BMSC niche and counters cognitive aging
Abstract Craniomaxillofacial bone marrow mesenchymal stromal cells (BMSCs) retaining neural crest–derived neurogenic niche is driven by lineage memory and niche homeostasis. Elucidating how the neurogenic potential is maintained is critical for neurological health. Here, we explored a neural…
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Artikel Jurnal
Identification of GLDN+ odontogenic stem cells as crucial for human tooth development and regeneration
Abstract The dental papilla (DP) is essential for the development of dentin and pulp. The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures during odontogenesis. However, the critical cell types within human DP that…
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Artikel Jurnal
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux
Abstract Splice quantitative trait loci (sQTL) serve as another critical link between genetic variations and human diseases, besides expression quantitative trait loci (eQTL). Their role in oral squamous cell carcinoma (OSCC) development remains unexplored. We collected surgically resected cancer…
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Artikel Jurnal
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities
Abstract Dento-maxillofacial abnormalities are highly prevalent and arise as a result of a variety of etiological factors, presenting substantial challenges to treatment. The JAK-STAT signaling plays a pivotal role in dentofacial development, regulating endochondral ossification, intramembranous…
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Artikel Jurnal
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion
Abstract Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abrasion or demineralization. For an effective long-term therapeutic desensitizing agent, the ability to achieve deep tubular occlusion, stable remineralization, and…
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Artikel Jurnal
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
Abstract Enamel, the hardest mineralized material in the human body, protects the underlying living tissues, the dentin and pulp of the tooth. However, over 90% of adults have lost or damaged enamel and cannot regenerate the protective structure due to lack of enamel-producing cells, ameloblasts…
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Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism
Abstract Copper, predominantly present in bones, plays a crucial role in bone formation. However, when copper homeostasis is disrupted, excessive copper can trigger harmful inflammation and a novel form of cell death known as cuproptosis. The impact of cuproptosis on bone metabolism remains…
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Artikel Jurnal
Enamel decussation pattern originates from directional sliding of ameloblasts
Abstract Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastructural level, it consists of directionally…
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Artikel Jurnal
Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis
Abstract Rheumatoid arthritis (RA) is an autoimmune disorder that triggers progressive joint destruction by inducing excessive osteoclastogenesis. Porphyromonas gingivalis (Pg), the main pathogenic bacterium involved in periodontitis (PD), is closely related to RA. Pg can secrete extracellular…
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Artikel Jurnal
LOXL2 deletion triggers TMJ osteoarthritis, while overexpression protects it from NF-κB-induced chondrocyte apoptosis
Abstract Temporomandibular joint osteoarthritis (TMJ-OA) affects a significant proportion of the population worldwide. However, there has been no substantial progress in the development of FDA-approved drugs for treatment due to a lack of understanding of the specific factors regulating key TMJ-OA…
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Artikel Jurnal
Engineered Lactobacillus reuteri for scavenging reactive oxygen species and modulating oral microflora in periodontitis therapy
Abstract The onset and progression of periodontitis are closely associated with subgingival dysbiosis and excessive localized oxidative stress. While some oral probiotics exhibit certain inhibitory effects on periodontitis-related pathogens, they often struggle to effectively colonize and…
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Stimuli-responsive, antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration
Abstract Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials. Here, nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon entry into oral biofilms are reviewed…
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Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways
Abstract Excessive lighting is integral to dentists’ daily routines but can impair their vision, affecting personal and professional performance. Most studies focus on acute photodamage, neglecting chronic photo-injury from dental lighting and its impact on the blood-retinal barrier homeostasis. An…
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Artikel Jurnal
Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction
Abstract Alveolar bone resorption during the socket healing process compromises subsequent restoration outcomes. Recent clinical evidence suggests that dental implant placement can effectively prevent such bone loss, yet the mechanisms remain elusive. In this study, combined multi-dataset screening…
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Artikel Jurnal
ID3-directed sonogenetics to enhance osteogenesis and bone defect healing
Abstract Sonogenetics, a noninvasive approach combining ultrasound physics with genetic engineering, has shown clinical potential in promoting bone repair. However, its therapeutic efficacy remains suboptimal due to the scarcity of bone-specific ultrasound-responsive targets and insufficient…