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Endocrine Connections
Scopus
ISSN 2049-3614 · Bioscientifica · 1.645 artikel di indeks
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Artikel Jurnal
The value of serum creatinine-to-cystatin C ratio in newly diagnosed ketosis-prone diabetes
Purpose: Ketosis-prone diabetes (KPD) is a new subtype of diabetes distinct from traditional type 2 diabetes, and the role of muscle mass in KPD remains unclear. Serum creatinine-to-cystatin C ratio (CCR) has been identified as a marker of muscle mass. The present study aims to investigate the…
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Artikel Jurnal
Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in response to an oral glucose challenge (as a…
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Artikel Jurnal
A systematic review of ipilimumab-induced hypophysitis
Background: Ipilimumab, a CTLA-4-targeting monoclonal antibody, enhances T-cell activation and improves outcomes in various malignancies. However, it is associated with immune-related adverse events (IRAEs), including hypophysitis – a rare but potentially life-threatening condition. This review…
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Artikel Jurnal
Continuous subcutaneous hydrocortisone infusion in pediatric primary adrenal insufficiency: a cohort study
Objective: Primary adrenal insufficiency (PAI) in children, most commonly caused by congenital adrenal hyperplasia (CAH), is challenging to treat due to the short half-life of hydrocortisone and the difficulty in mimicking the physiological rhythm of cortisol. Continuous subcutaneous hydrocortisone…
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Artikel Jurnal
PERSPECTIVE: Prioritizing quality of life in the management of hyperthyroidism: an expert clinical perspective
Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental and social functioning and well-being. Patients with hyperthyroidism often complain of anxiety, physical symptoms and tiredness. Concurrent thyroid eye disease (TED) further reduces QoL. With treatment of…
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Artikel Jurnal
Glucocorticoid-induced adrenal insufficiency: physiological dose tapering promotes recovery
Objective: Glucocorticoid discontinuation is complicated by glucocorticoid-induced adrenal insufficiency. Guidelines discourage tapering below physiological doses (prednisolone 3–6 mg) when morning cortisol is ≤300 nmol/L, with values 2 mg producing larger cortisol increases than 1 mg reductions…
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Artikel Jurnal
Dynamic testing of cortisol in consecutive patients with suspected adrenal disorders: a comparison of Elecsys Cortisol II and LC-MS/MS
The increased detection of adrenal incidentalomas and drug-induced adrenal insufficiency increases the demand for cortisol testing. While liquid chromatography–tandem mass spectrometry (LC-MS/MS) and dynamic testing remain the gold standard, more expedient tools are needed. We compared the Elecsys…
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Artikel Jurnal
Distribution of glucagon-like peptide 1 receptor and insulin in phaeochromocytomas
Introduction: Most phaeochromocytomas produce insulin, and some produce glucagon-like peptide 1 receptor (GLP-1R). In pancreatic β-cells, stimulation of GLP-1R causes insulin release. A few phaeochromocytoma patients experience hypoglycaemic attacks. Therefore, we studied the distribution of…
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The impact of hyperparathyroidism on skeletal muscle pathophysiology and physical function
Primary hyperparathyroidism (PHPT), increasingly diagnosed in its asymptomatic form, is associated with clinically significant neuromuscular dysfunction. Growing evidence indicates that skeletal muscle is a direct target of parathyroid hormone (PTH), with chronic PTH excess impairing mitochondrial…
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Artikel Jurnal
Reduced plasma epidermal growth factor levels reflect poor glycaemic status in type 2 diabetes
Background: Epidermal growth factor (EGF) plays a crucial role in cellular growth, differentiation, and pancreatic β-cell maintenance. Despite reports on EGF deficiency in diabetic animal models, its relevance in type 2 diabetes (T2D), particularly in relation to obesity, remains underexplored. The…
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Artikel Jurnal
Associations between CT-based body composition parameters and glycemic control in adults with type 2 diabetes mellitus: a retrospective cohort study
Background: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and impaired insulin secretion, leading to persistent hyperglycemia and multisystem complications. Adipose tissue distribution – visceral, subcutaneous, and intermuscular – varies in metabolic and inflammatory…
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Artikel Jurnal
Exploring the risk of depression and suicide/self-injury in patients receiving GLP-1RAs combined with metformin versus GLP-1RA monotherapy: a real-word analysis of the FAERS database
Objective: This study aimed to assess the latent threat of depression and suicide/self-injury associated with the combination of glucagon-like peptide-1 agonists (GLP-1RAs) and metformin versus GLP-1RAs monotherapy, through analyzing the data from the Food and Drug Administration (FDA) Adverse…
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Artikel Jurnal
Association between younger-onset type 2 diabetes and long-term risk of CVD events: a 34-year follow-up of the Da Qing Diabetes Prevention Study
Background and aims: This study aimed to explore whether a younger age of diabetes onset is associated with an increased risk of CVD events. Methods: This study included 621 patients with younger-onset T2DM (age, ≤50 years) and 573 with older-onset T2DM (age, >50 years) from the original Da Qing…
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Artikel Jurnal
Metabolic, enterohepatic and gut microbial effects of atorvastatin in healthy men
Objective: Statins are low-density lipoprotein cholesterol-lowering drugs that are highly effective in the prevention of cardiovascular disease and death. Evidence that statin therapy increases the risk of type 2 diabetes is accumulating, but the mechanism behind this phenomenon remains obscure…
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Artikel Jurnal
Digital vs conventional glycemic monitoring in rare endocrine cancers: comparison of effectiveness during chemotherapy
Aims: Chemotherapy regimens can induce severe hyperglycemia, which may be underestimated using conventional point-of-care blood glucose (POC-G) measurement techniques. Real-time continuous glucose monitoring (rtCGM) systems may offer a more accurate assessment of glucose metabolism. In this study…
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Artikel Jurnal
Burosumab for adults with tumor-induced osteomalacia in China
A better understanding of the benefit of burosumab for treating tumor-induced osteomalacia (TIO) in Chinese patients is needed. The objective of this open-label, multicenter, single-cohort, post-marketing phase 4 study was to assess the efficacy, pharmacokinetics, pharmacodynamics, and safety of…
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Artikel Jurnal
ACTH and renin in 529 healthy youths: associations to sex, puberty and contraceptives
Objective: To establish sex- and age-specific reference intervals for plasma concentrations of adrenocorticotropic hormone (ACTH) and direct renin in healthy youth. Design: 529 healthy subjects (5.8–20.4 years) were recruited as part of the third Copenhagen Puberty Study, an ongoing cross-sectional…
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Artikel Jurnal
Prevalence and prognostic impact of rhabdomyolysis in adults hospitalized with diabetic ketosis: a 10-year single-center cohort study
Objective: To determine the prevalence and clinical impact of rhabdomyolysis (RML) among adults hospitalized with diabetic ketosis. Design: Ten-year retrospective single-center cohort study. Methods: We reviewed adults admitted with diabetic ketosis, including isolated ketosis and diabetic…
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