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Therapeutic Advances in Infectious Disease
Scopus
ISSN 2049-937X · SAGE Publishing · 583 artikel di indeks
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Artikel Jurnal
Determinants of active pulmonary tuberculosis and implications of a novel mining risk factor for TB control: An unmatched case-control study in Guji Zone, Oromia Region, Ethiopia
Background Tuberculosis (TB) remains a major global health challenge, especially in low-income countries like Ethiopia. Despite ongoing control efforts, TB remains prevalent, highlighting the need for more in-depth research. Guji Zone of Oromia Region is among high TB burden zones in Ethiopia with…
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Artikel Jurnal
Prevalence of perceived stigma and associated factors among patients with tuberculosis in Napak district, Karamoja region, Uganda: A cross-sectional study
Background Tuberculosis (TB) remains a leading cause of infectious disease mortality globally. Stigma is a critical social determinant that undermines health-seeking behavior and treatment adherence, threatening TB control. The Karamoja region in Uganda has the highest TB burden and continues to…
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Artikel Jurnal
Respiratory pathogen detection and Co-detection in hospitalized children with lower respiratory tract infections using multiplex RT-qPCR: A single-center retrospective Observational Study
Background Lower respiratory tract infections (LRTIs) are a common cause of pediatric hospitalization, but distinguishing viral from bacterial etiologies based solely on clinical findings remains challenging. Multiplex real-time polymerase chain reaction (RT-qPCR) enables the simultaneous detection…
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Artikel Jurnal
Modeling the potential clinical and economic impact of clesrovimab for the prevention of RSV in infants in England and Wales
Background Respiratory syncytial virus (RSV) infects nearly all children under two years, causing mild lower respiratory tract infections (LRTIs) although serious disease, mortality and long-term recurrent wheezing can also occur. Objectives This study evaluates the health and economic impact of…
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Artikel Jurnal
Community perspectives on hepatitis B transmission and vaccination among adults in Northwest Ethiopia: a qualitative study
Background: Hepatitis B virus (HBV) infection remains a major public health problem in sub-Saharan Africa, including Ethiopia, where adult vaccination uptake is limited. While quantitative studies have assessed knowledge and attitudes, little is known about how culturally embedded beliefs shape…
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Artikel Jurnal
Treatment gaps and risk factors for multidrug-resistant Enterobacterales in Belize: a 6-year (2018–2023) nationwide retrospective analysis
Background: Antimicrobial resistance (AMR) in Escherichia coli , Klebsiella pneumoniae , and Enterobacter cloacae is a global threat, yet data from Belize and the wider Caribbean are scarce. Understanding local resistance patterns is critical for effective treatment and stewardship. Objectives: To…
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Artikel Jurnal
Interpretable machine learning models for pre- and postoperative prediction of early intra-abdominal infections after liver transplantation: a multicenter retrospective cohort study
Background: Early intra-abdominal infections (EIAIs) are among the most frequent and life-threatening complications following liver transplantation (LT). Early identification of high-risk patients remains challenging, and no standardized risk stratification tool is currently available. Objective…
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Artikel Jurnal
Precision geospatial targeting for cost-effective tuberculosis case finding in Eastern Uganda: a quasi-experimental study
Background: Universal community-based tuberculosis (TB) screening in high-burden settings is resource-intensive and inefficient, frequently missing cases and leading to suboptimal resource allocation. Integrating routine surveillance data with geospatial analytics offers a promising approach to…
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Artikel Jurnal
Secondary spontaneous pneumothorax due to extensive pulmonary tuberculosis in a patient with acute hepatitis B flare: clinical challenges and therapeutic decision making—a case report
Secondary spontaneous pneumothorax (SSP), particularly when complicated by a persistent air leak, is an uncommon but serious manifestation of active pulmonary tuberculosis. Such cases often require pleural drainage or surgical intervention. Management becomes significantly more challenging when…
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Artikel Jurnal
Bacterial neonatal sepsis, antimicrobial resistance, and risk factors among neonates in Ethiopia: a systematic review and meta-analysis
Background: Antimicrobial resistance and bacterial neonatal sepsis are major threats causing high morbidity and mortality among neonates in developing countries, including in Ethiopia. Given the lack of comprehensive and synthesized evidence on the magnitude of the bacterial profile, neonatal…
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Artikel Jurnal
Prognostic factors in the selection of antivirals for COVID-19 in high-risk outpatients: A retrospective cohort study
Background Early oral antiviral treatment reduced disease progression and hospitalisation in high-risk COVID-19 outpatients. In practice, prescribing decisions were influenced by clinical risk, drug interaction concerns, and physician judgment, even in settings where guidelines prioritised…
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Artikel Jurnal
Bacterial profile and antimicrobial resistance patterns of infected diabetic foot ulcers in low- and middle-income countries: a systematic review and meta‑analysis
Background: Diabetic foot ulcers (DFUs) are often polymicrobial infections, necessitating antibiotic therapy. However, the high prevalence of antibiotic misuse and the growing issue of antibiotic resistance in low- and middle-income countries (LMICs) exacerbate the challenges in managing these…
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Artikel Jurnal
Association of alanine aminotransferase flares with hepatitis B surface antigen loss and clinical outcomes in treated and untreated patients with chronic hepatitis B virus infection: A US retrospective cohort study
Background Previous research has demonstrated the clinical significance of alanine aminotransferase (ALT) flares; however, studies have mostly been in Asian countries or populations, and it remains unclear whether ALT flares during treatment are associated with hepatitis B surface antigen (HBsAg)…
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Artikel Jurnal
Managing HIV care in daily life: A qualitative study of ART adherence and retention barriers and facilitators among people attending two urban ART clinics in Panama
Background Optimal antiretroviral therapy (ART) adherence and retention in HIV care are important for viral suppression among people living with HIV (PLHIV). Although ART is free in Panamanian public clinics, ART adherence and care continuity remain challenges. Prior studies in Panama have…
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Artikel Jurnal
High-risk HPV detection via GeneXpert in self-collected anal swabs among MSM living with HIV: Insights from a cross-sectional study
Background Men who have sex with men living with HIV (MSMLWHIV) have a high risk of persistent high-risk HPV infection, and rapid tools like Xpert HPV can help expand screening in low-resource settings. Objectives This study aimed to assess the feasibility of using self-collected anal swabs for…
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Artikel Jurnal
Respiratory morbidity in human toxocariasis: A scoping review of the literature
Background Human toxocariasis is among the most common helminthic zoonoses worldwide, and larvae traverse the lungs during visceral migration. Respiratory morbidity among diagnosed patients remains poorly characterised, in contrast to the much larger seroepidemiological literature linking Toxocara…
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Artikel Jurnal
Community awareness, perception, and preventive practices towards rabies in Ethiopia: A systematic review and meta-analysis
Background Rabies is a major global public health problem, with case fatality rate approaching 100% once clinical symptoms appear, causing severe neurological complications and significant social and economic burdens. Ethiopia bears a high burden of rabies, with the disease remaining endemic and…
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Artikel Jurnal
Determinants of visceral leishmaniasis among patients admitted to selected public hospitals in Guji and Borena Zones, southern Oromia, Ethiopia: An unmatched case-control study
Background Visceral leishmaniasis (VL) remains a significant public health concern in East Africa, with an estimated 30,000 cases reported annually. Ethiopia is among the most affected countries in the region, with the southern part of the country bearing a substantial share of the disease burden…