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Clinical & Translational Immunology
Scopus
ISSN 2050-0068 · Wiley · 546 artikel di indeks
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Artikel Jurnal
Integrating mass spectrometry‐based multi‐omic signatures of extracellular vesicles: from discovery to clinical translation
Abstract Extracellular vesicles (EVs) are increasingly recognised as key mediators of intercellular communication and disease progression. Their capacity to carry bioactive molecules, namely proteins, lipids and metabolites, reflects the physiological and pathological states of their cells of…
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Artikel Jurnal
A novel surface plasmon resonance approach to assess anti‐dsDNA antibody kinetics and disease severity in systemic lupus erythematosus
Abstract Objectives Anti‐dsDNA antibodies are established biomarkers in systemic lupus erythematosus (SLE), yet the clinical utility of conventional assays remains limited by variable analytical performance. We evaluated a novel Fibre‐Optic Surface Plasmon Resonance (FO‐SPR) biosensor for real‐time…
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Artikel Jurnal
Dissecting infant and maternal antibody repertoires exposes the early onset of infant humoral immunity
Abstract Objectives The early development of humoral immunity is important for long‐term protection of the newborn. Here, we set out to discern these infant‐produced antibodies from the vast background of maternal antibodies, which is challenging but essential to shed light on the infant‐produced…
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Artikel Jurnal
Immune activation and response dynamics of human iPSC‐derived macrophages in tuberculosis infection models
Abstract Objectives Tuberculosis (TB) remains a global health challenge, with current antibiotic therapies being limited by long treatments, side effects and multidrug‐resistant mycobacterial strains. In addition, Mycobacterium tuberculosis (Mtb), the main causative agent of TB, employs evasion…
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Artikel Jurnal
A comprehensive analysis of the correlation between plasma cytokines/chemokines and tumor immune microenvironment signature influences the response of checkpoint inhibitors in advanced non‐small‐cell lung cancer
Abstract Objectives Circulating cytokines/chemokines are linked to checkpoint inhibitors (ICIs) in non‐small cell lung cancer (NSCLC). The tumor‐immune microenvironment (TIME) plays a significant role in modulating a broad range of cytokines and chemokines. This study aimed to explore the crosstalk…
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Artikel Jurnal
Prolonged persistence of tissue‐resident memory cells in the upper airway following SARS‐CoV‐2 infection and vaccination
Abstract Objectives Here, we characterised the diversity and persistence of immunological memory cells—particularly tissue‐resident memory T (TRM) and B (BRM) cells—in the nasopharyngeal lymphoid tissues of healthy vaccinated (HV) individuals and those who experienced SARS‐CoV‐2 breakthrough…
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Artikel Jurnal
Integrated humoral and inflammatory signatures predict outcomes in severe COVID‐19: a 14‐day longitudinal analysis
Abstract Background Severe COVID‐19 is marked by profound immune dysregulation, yet the interplay between humoral and inflammatory responses that determines clinical outcomes in critically ill patients remains incompletely understood. We evaluated longitudinal antibody and soluble immune mediator…
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Artikel Jurnal
Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut–brain endothelial dysfunction
Abstract Objective Aicardi–Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism with secondary host anti‐viral (interferon) activation. This metabolomics study aimed to improve the biological understanding of AGS and explore potential biomarkers…
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Artikel Jurnal
The impact of B‐cell reconstitution on mRNA vaccine responses in allogeneic stem cell transplant recipients
Abstract Objectives Vaccine responses in haematopoietic stem cell transplant (alloHCT) recipients vary, with different degrees of B‐cell reconstitution likely playing a key role. However, mechanistic understanding of the B‐cell receptor (BCR) repertoire and its functional impact post‐alloHCT remain…
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Artikel Jurnal
CD56bright NK cells are negatively associated with antibody response to vaccination in people with multiple sclerosis on B‐cell‐depleting therapy
Abstract Objectives We sought to identify determinants of vaccine response in people with multiple sclerosis (pwMS) receiving B‐cell‐depleting therapies. Methods This was a prospective single‐centre cohort study (ACTRN12623001249640). Peripheral blood samples were collected from pwMS receiving…
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Artikel Jurnal
Manufacturing cost analysis and exploratory economic evaluation of natural killer cell immunotherapy for paediatric solid tumors
Abstract Objectives Natural killer (NK) cell therapy is a promising allogeneic, off‐the‐shelf immunotherapy for solid tumors, yet economic evidence to guide its clinical translation is absent. This study aimed to conduct a micro‐costing analysis of their manufacturing and perform an exploratory…
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Artikel Jurnal
Prolonged molecular control during intermittent reduced‐intensity blinatumomab maintenance in a transplant‐ineligible patient with Philadelphia chromosome‐positive acute lymphoblastic leukaemia and IKZF1 deletion
Abstract Objectives Long‐term disease control in transplant‐ineligible patients with high‐risk Philadelphia chromosome‐positive acute lymphoblastic leukaemia (Ph+ ALL) remains difficult, particularly when adverse genetic lesions and acquired kinase domain mutations coexist. Methods Clinical…
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Parallel processing of T cells and natural killer cells to enhance in vivo CAR T cell activity against blood and solid cancers
Abstract Objectives Despite their anti‐cancer properties, natural killer (NK) cells are discarded during CAR T cell manufacturing. NK cells display promising responses as a cell therapy, exhibiting remarkable safety at high doses. Moreover, NK cells have complementary cytokine profiles and distinct…
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Artikel Jurnal
High‐dimensional multiomics reveals perturbations to IL‐6/IL‐6R axis and RUNX3 in CD4+ T cells during third‐trimester pregnancy
Abstract Objectives CD4+ T cells play key roles in regulating immune responses during pregnancy; therefore, we aimed to understand the CD4+ T‐cell surface proteome and transcriptome during pregnancy. Methods CD4+ T cells were analysed in blood and decidua from term pregnancies (> 37 weeks) and…
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Artikel Jurnal
Enhanced Fc and complement activity of Fc‐modified avelumab boosts anti‐tumor activity but promotes NK cell fratricide
Abstract Objectives The anti‐PD‐L1 antibody avelumab has demonstrated efficacy across multiple cancer types. Avelumab primarily blocks the PD‐1/L1 immune checkpoint, while inducing antibody‐dependent cellular cytotoxicity (ADCC) from CD16a+ NK cells. However, subsets of patients possess…
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Artikel Jurnal
A novel case of autosomal recessive CARD11 loss‐of‐function underlying impaired antiviral immunity and a review of literature
Abstract Objectives Germline CARD11 variants lead to a spectrum of disease depending on the effect of signalling augmentation or impairment. Autosomal recessive (AR) CARD11 loss‐of‐function (LOF) is rare with only 12 cases reported to date. Methods Clinical and immunological information was…
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Artikel Jurnal
Aberrant intra‐epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103‐β7‐receptor‐mediated granzyme‐B degranulation which can be restored by etrolizumab
Abstract Objectives Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra‐epithelial T‐lymphocytes (IEL). The severe enteropathy found in RCDII is caused by aberrant IEL that exert cytotoxicity against enterocytes. In this study, we investigated the cell death mechanism…
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Artikel Jurnal
Characterisation of tumor‐infiltrating gamma‐delta T cells in human colorectal cancer with MHC‐I loss
Abstract Objectives Gamma‐delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhibit an intrinsic tropism for the tumor microenvironment, largely driven…
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Artikel Jurnal
Control of poorly immunogenic tumors with systemic STING agonist‐loaded liposomes targeting cross‐presenting dendritic cells
Abstract Objectives Cancer vaccines combine tumor antigen and adjuvant to drive an anti‐tumor immune response. Clec9A‐targeted nanoparticles directing CD4 and CD8 neo‐epitopes to cross‐presenting dendritic cells (DCs) stimulate adjuvant‐free therapeutically effective tumor‐specific immunity…
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Artikel Jurnal
Effect of CXCR5, PD‐1 and ICOS on B‐cell responses and relevance to myasthenia gravis
Abstract Objectives T follicular helper (Tfh) cells regulate B‐cell responses within germinal centres primarily via programmed cell death protein 1 (PD‐1) and inducible T‐cell costimulator (ICOS), whereas CXC chemokine receptor type 5 (CXCR5)‐negative T peripheral helper (Tph) cells provide similar…