19.653 hasil
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eLife
ISSN 2050-084X · eLife Sciences Publications Ltd · 19.653 artikel di indeks
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Artikel Jurnal
Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring
DNA origami technology is a method for designing and constructing nanoscale structures using DNA, and it is being applied across various fields. This technology was advanced by developing the nanospring (NS), a fluorescently visible molecular spring that quantifies forces through its extension and…
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The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients
Understanding the physical basis of cellular shape change in response to both internal and external mechanical stresses requires characterisation of cytoplasmic rheology. At subsecond time-scales and micron length-scales, cells behave as fluid-filled sponges in which shape changes necessitate…
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Executive resources shape the impact of language predictability across the adult lifespan
Humans routinely anticipate upcoming language, but whether such predictions come at a cognitive cost remains debated. In this study, we demonstrate the resource-dependent nature of predictive mechanisms in language comprehension across the lifespan: Experimentally limiting executive resources…
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Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onwards
Avian influenza (AI) is a highly contagious viral disease affecting poultry and wild water birds, posing significant global challenges due to its high mortality rates and economic impacts. Highly pathogenic avian influenza (HPAI) outbreaks, particularly those caused by H5N1 and its variants, have…
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Mast cells promote pathology and susceptibility in tuberculosis
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), infects approximately one-fourth of the world’s population. We reported an increased accumulation of mast cells (MCs) in the lungs of macaques with active pulmonary TB (PTB), compared with those with latent TB infection…
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Identifying regulators of associative learning using a protein-labelling approach in Caenorhabditis elegans
The ability to learn and form memories is critical for animals to make choices that promote their survival. The biological processes underlying learning and memory are mediated by a variety of genes in the nervous system, acting at specific times during memory encoding, consolidation, and…
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Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty acyltransferase
Legionella pneumophila is an opportunistic bacterial pathogen that causes Legionnaires’ disease. To establish an intracellular niche conducive to replication, L. pneumophila translocates a diverse array of effector proteins that manipulate various host cellular processes, including the actin…
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Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making
Humans and animals can flexibly choose their actions based on different information, ranging from objective states of the environment (e.g., apples are bigger than cherries) to subjective preferences (e.g., cherries are tastier than apples). Whether the brain instantiates these different choices by…
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Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location
Even seemingly homogeneous populations of cells can express phenotypic diversity in response to environmental changes. Thus, X-ray irradiation of tissues composed of diverse cell types can have complex outcomes. We have used single-cell RNA sequencing to study the effects of X-ray radiation on the…
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Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration
Skeletal muscle regeneration is a multistep process involving the activation, proliferation, differentiation, and fusion of muscle stem cells, known as satellite cells. Fusion of satellite cell-derived myoblasts (SCMs) is indispensable for generating the multinucleated, contractile myofibers during…
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Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function
The rapid and sustained proliferation of cancer cells necessitates increased protein production, which, along with their disrupted metabolism, elevates the likelihood of translation errors. Ribosome-associated quality control (RQC), a recently identified mechanism, mitigates ribosome collisions…
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Feeding rates in sessile versus motile ciliates are hydrodynamically equivalent
Motility endows microorganisms with the ability to swim to nutrient-rich environments, but many species are sessile. Existing hydrodynamic arguments in support of either strategy, to swim or to attach and generate feeding currents, are often built on a limited set of experimental or modeling…
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Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells
Tendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging. We investigated the characteristics of tendon stem/progenitor cells (TSPCs) by focusing on the declining tendon repair capacity with growth. Using…
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Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B
Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases, including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA-DR3 haplotype…
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A geometric shape regularity effect in the human brain
The perception and production of regular geometric shapes, a characteristic trait of human cultures since prehistory, has unknown neural mechanisms. Behavioral studies suggest that humans are attuned to discrete regularities such as symmetries and parallelism and rely on their combinations to…
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Human brain dynamics and spatiotemporal trajectories during threat processing
Functional MRI (fMRI) research has traditionally investigated task processing using static blocked or event-related designs. Consequently, our understanding of threat processing remains limited to findings from paradigms with restricted dynamics. In this paper, we applied switching linear dynamical…
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Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs
Despite the growing public health threat of electronic cigarettes (e-cigs), the cell-specific immune responses to differently flavored e-cig exposure remain poorly understood. To bridge this gap, we characterized the lung immune landscape following acute nose-only exposure to flavored e-cig…
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Accelerated evolution in networked metapopulations of Pseudomonas aeruginosa
Natural populations are often spatially structured, meaning they exist as metapopulations composed of subpopulations connected by migration. Little is known about the impact of spatial structure, in particular the topology of connections among subpopulations, on adaptive evolution. Typically…
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