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SAGE Open Medicine
Scopus
ISSN 2050-3121 · SAGE Publishing · 2,277 articles in the index
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Journal Article
Association of pre-procedural state and trait anxiety with myocardial perfusion SPECT findings: A prospective observational study in patients undergoing 99mTc-Sestamibi imaging
Background Anxiety is common among patients undergoing myocardial perfusion SPECT (MPS). This study aimed to investigate whether pre-procedural state anxiety influences MPS outcomes and to compare the predictive value of state versus trait anxiety. Methods This prospective observational study…
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Journal Article
Prevalence of suboptimal health status and its association with insomnia and smartphone addiction among medical students in Palestine: A multi-university cross-sectional study
Background Suboptimal health status (SHS) is a reversible intermediate state between health and disease. It is associated with the early development of chronic conditions and is strongly influenced by lifestyle factors. Medical training may foster unhealthy lifestyle patterns that increase…
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Journal Article
WEE1 as a checkpoint regulator and therapeutic vulnerability: From biology to clinical development
WEE1 is a critical cell-cycle checkpoint kinase that inhibits cyclin-dependent kinase activity via phosphorylation, coordinating DNA replication, repair, and mitotic entry. Although primarily recognized for its canonical function at the G2/M checkpoint, WEE1 also modulates S-phase dynamics by…
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Journal Article
Self-medication practices and associated knowledge among health sciences students: A cross-sectional study
Objectives To investigate the prevalence, knowledge, and factors associated with self-medication among students at the University of Wolverhampton, UK, including examination of medication knowledge, advertising influences, and awareness of harmful effects. Methods A cross-sectional study was…
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Journal Article
Subnational trends and regional disparities in HIV burden among reproductive-age women in Ethiopia, 1990-2023: Analysis of global burden of diseases 2023 estimates
Objective The aim of this study was to estimate the age standardized rate of prevalence, incidence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) due to Human Immune Deficiency (HIV) among reproductive-age women in Ethiopia from…
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Journal Article
Prevalence of short birth interval and associated factors among women, who gave birth in the past three years in Shebedino woreda, sidama region, Ethiopia, 2023
Background Short birth intervals significantly increase the risk of adverse maternal and neonatal outcomes like preterm birth, low birth weight, and maternal anemia. While optimizing birth spacing is critical for reproductive health interventions, localized and up-to-date epidemiological data from…
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Journal Article
Cutaneous manifestations in infants evaluated for congenital syphilis: A 10-year retrospective study
Background Congenital syphilis remains a preventable cause of neonatal morbidity and mortality despite effective antenatal screening and treatment. Cutaneous manifestations are among the earliest recognizable clinical signs and may facilitate prompt diagnosis. This study evaluated maternal and…
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Journal Article
Accelerating autism prevalence in California with changepoint in the mid-2010s and divergence by county and socioeconomic indicators
Background/Objectives The Autism and Developmental Disabilities Monitoring (ADDM) network has observed an ongoing increase in autism spectrum disorder (ASD) among U.S. children, with highest prevalence in California. Recent county-level trends in California were analyzed to provide insight into…
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Journal Article
Characteristics of junior residents choosing alternative career pathways without entering traditional specialty residency programs: An exploratory descriptive study
Objectives In Japan, the standard post-training trajectory for physicians involves entering a specialty residency program to obtain board certification. However, a growing number of recent graduates are opting for alternative career pathways immediately following their two-year mandatory…
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Journal Article
Household disposal of unused and expired medications in Bahir Dar City, Northwest Ethiopia: Knowledge, attitudes, practices, and factors associated with good disposal practices
Introduction Proper household management of unused and expired medications reduces environmental and public health risks. The aim of this study was to assess household knowledge, attitudes, and disposal practices of unused and expired medications, and identifies factors associated with good…
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Journal Article
Association of COVID-19 vaccination before 12 weeks of gestation with ultrasound-detected congenital anomalies compared with later or no vaccination: A registry-based cohort study
Objective Our objective was to evaluate the occurrence of congenital anomalies in pregnant women who received at least one dose of COVID-19 vaccine from conception up to 11 w and 6 d in comparison to those vaccinated after 12 weeks of pregnancy or not vaccinated at all. Methods This study is a…
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Journal Article
Link between physical activity, nutrition, and antimicrobial pharmacokinetics and therapeutic efficacy: Implications for resistance management
Antimicrobial resistance (AMR) is a critical global health challenge, as it reduces the effectiveness of current therapies and demands novel integrative approaches. This narrative, integrative review analyzes how physical activity and nutrition interact with the pharmacological design of…
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Journal Article
The effect of voluntary chronic alcohol consumption on Th1/Th2 cytokine signature during adolescence in Sprague-Dawley Rats
Background: Chronic alcohol use is a global health concern with adverse effects on immune function, potentially altering the T-helper (Th)1/Th2 axis. This study modelled chronic alcohol consumption using Sprague–Dawley (SD) rats to determine whether chronic alcohol consumption during adolescence…
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Journal Article
Invasive versus non-invasive management in non-ST segment elevation myocardial infarction patients with pulmonary hypertension
Background Non–ST-segment elevation myocardial infarction (NSTEMI) represents a substantial proportion of acute coronary syndrome and is associated with considerable morbidity and mortality. Pulmonary hypertension (PH) is linked to adverse cardiovascular outcomes and may complicate management…
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Journal Article
Association between hospital overcrowding-related stress and self-reported medical errors among nurses in government healthcare facilities
Background Hospital overcrowding is a patient-safety concern in resource-constrained health systems, where limited bed capacity, staffing shortages, high patient acuity, and weak organizational support increase pressure on nurses. Although international evidence links crowded clinical environments…
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Journal Article
Time to death and its predictors among adults on mechanical ventilation at Hiwot Fana comprehensive specialized hospital, eastern Ethiopia: A retrospective cohort study
Introduction Mechanical ventilation is an essential lifesaving intervention for patients with severe illness. Mortality among patients receiving mechanical ventilation is high in low-resource settings, including Ethiopia. Evidence on predictors of time to death in such settings is limited…
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Journal Article
Determinants of pneumonia among adult asthmatic patients attending public hospitals in Awi Zone, Northwest Ethiopia: A case control study
Background Asthma and pneumonia are common respiratory conditions worldwide. Pneumonia is a life-threatening lung infection and a frequent comorbidity among adult asthmatic patients, often causing hospital admission. Despite the global burden, evidence on determinants of pneumonia among adult…
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Journal Article
Etiologic spectrum and predictors of visual acuity in non-glaucomatous optic atrophy
Aim To determine the prevalence and underlying causes of nonglaucomatous optic atrophy (NGOA) in a tertiary referral center in southeastern Iran and to identify predictors of current visual acuity in this population. Methods In this descriptive cross-sectional study, patients with a confirmed…
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Journal Article
Physicochemical and bacteriological quality of drinking water in Debre Markos town, Northwest, Ethiopia
Background Access to safe drinking water is essential for human health; however, water contamination remains a major concern in developing countries such as Ethiopia. Rapid urbanization and inadequate sanitation threaten water quality. This study evaluated the physicochemical and bacteriological…
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Journal Article
Magnitude and associated factors of poor surgical treatment outcomes of bowel obstruction in Ethiopia: A systematic review and meta-analysis
Introduction Bowel obstruction is a major surgical emergency associated with considerable postoperative morbidity and mortality, particularly in low-resource settings. Evidence on surgical outcomes in Ethiopia remains inconsistent. This systematic review and meta-analysis aimed to estimate the…
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