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Immunity, Inflammation and Disease
Scopus
ISSN 2050-4527 · Wiley · 1.541 artikel di indeks
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Artikel Jurnal
Concordance Analysis of ALEX‐2, ImmunoCAP, and Prick Test for Respiratory Allergies in Lima, Peru
ABSTRACT Background Accurate identification of respiratory allergen sensitization is essential for managing asthma and allergic rhinitis (AR). While Skin Prick Test (SPT) and ImmunoCAP are standard diagnostic tools, exploratory comparative data for the novel Allergy Explorer 2 (ALEX‐2) test in…
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Artikel Jurnal
Clinical Characteristics of Patients With Anti‐Signal Recognition Particle Antibody: A Cohort Study
ABSTRACT Background Anti‐signal recognition particle (anti‐SRP) antibodies are myositis‐specific autoantibodies associated with immune‐mediated necrotizing myopathy. This study was undertaken to better understand how patients with anti‐SRP antibodies have been managed at our tertiary centre and to…
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Artikel Jurnal
The Progress of Ferroptosis of Immune Cells in the Tumor Microenvironment and Its Impact on Tumorigenesis and Development
ABSTRACT Background The immune cells within the tumor microenvironment (TME) play important roles in tumorigenesis. Ferroptosis is an iron‐dependent form of non‐apoptotic cell death characterized by the accumulation of lipid peroxides. The interplay between ferroptosis and the tumor immune…
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Artikel Jurnal
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H2O2‐Damaged PC12 Cells
ABSTRACT Background Spinal cord injury (SCI) leads to severe neurological dysfunction. Current therapeutic strategies remain limited, with poor recovery rates. Oxidative stress and ferroptosis are key mechanisms underlying secondary SCI. Paeoniflorin has anti‐inflammatory, antioxidant, and…
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Artikel Jurnal
Association of the Geriatric Nutritional Risk Index With Prognosis in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
ABSTRACT Background and Aims The geriatric nutritional risk index (GNRI) has shown good predictive value for some diseases. However, its association with major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) remains…
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Artikel Jurnal
Liver Cirrhosis Caused by Food‐Borne Zoonotic Fasciola gigantica in Cattle in Bangladesh: Pathology and Immunological Orchestra
ABSTRACT Background Fasciolosis is a food‐borne parasitic zoonotic disease caused by widespread liver flukes that affect ruminants and humans, and is responsible for non‐resolving hepatic damage. Although fasciolosis occurs in both acute and chronic forms, chronic fasciolosis is more common…
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Artikel Jurnal
Role of Macrophages in Cardiac Remodeling: Cues From Zebrafish Heart
ABSTRACT Background Macrophages are a key component of innate immunity and regulate cardiac phenotypes by their polarization state. The classical M1 macrophages are activated by pro‐inflammatory stimuli, whereas M2 macrophages are activated by anti‐inflammatory stimuli. The balance between M1 and…
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Artikel Jurnal
Bilateral Chronic Expanding Hematomas of the Gluteus Maximus Presenting With Gluteal Muscle Contracture: A Case Report
ABSTRACT Background Chronic expanding hematoma is defined as a progressively enlarging soft tissue mass persisting beyond 1 month, typically resulting from prior trauma or surgical procedures. Although the condition is rare, its occurrence within deep musculature—particularly with bilateral…
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Artikel Jurnal
Kaempferitrin Attenuates Lipopolysaccharide‐Induced Cardiac Dysfunction Through Suppression of the NF‐κB/NLRP3 Signaling Pathway
ABSTRACT Purpose The inflammatory activation and metabolic disorders of cardiomyocytes are essential mechanisms in sepsis‐related cardiac dysfunction. Kaempferitrin (Kae), a flavonoid compound, possesses various properties including anti‐inflammatory and anti‐glycation effects. Hence, the current…
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Artikel Jurnal
Integrated Analysis of the Immune Infiltration Pattern and Novel Diagnostic Biomarkers in Septic Cardiomyopathy
ABSTRACT Purpose In this study, various informatics analyses were employed to identify the hub genes associated with septic cardiomyopathy (SCM) onset and investigate their immune infiltration status. Methods High‐throughput sequencing data of myocardial tissue samples from mice with SCM were…
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Artikel Jurnal
COVID‐19‐Related Hematological Abnormalities Among Adults; A Cross‐Sectional Study in a Resource‐Limited Setting
ABSTRACT Background Alterations in hematological parameters in SARS‐CoV‐2 infection may contribute to disease severity and poor outcomes. This study reports the hematological profile of COVID‐19 patients. Methods This was a cross‐sectional study involving 169 confirmed COVID‐19 patients conducted…
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Artikel Jurnal
MAFG Induces the Methylation of CRYAB to Promote the Activation of A1 Astrocyte After Spinal Cord Injury
ABSTRACT Purpose To investigate the effects of MAF bZIP transcription factor G (MAFG) on the transformation of A1/A2 reactive astrocytes and the production of inflammatory factors after spinal cord injury (SCI). Methods An SCI model was established using Sprague–Dawley rats. Astrocyte conditioned…
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Artikel Jurnal
Short‐Term Change in IgG Antibody Elicited by Omicron BA.5 Infection and Inhaled Ad5‐nCoV Vaccine Among Healthcare Workers
ABSTRACT Background Little is known about the immune response induced by the SARS‐CoV‐2 Omicron BA.5 variants or the inhaled adenovirus vector vaccine. In this study, we investigated the short‐term profile of antireceptor‐binding‐domain IgG antibody responses elicited by either the virus or the…
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Artikel Jurnal
Lipoic Acid Ameliorates Lipopolysaccharide‐Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages
ABSTRACT Background Sustained pulmonary inflammation contributes significantly to lung carcinogenesis. Macrophages play a pivotal role in perpetuating inflammatory responses, undergoing a metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis upon activation. The interplay between…
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Artikel Jurnal
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its…
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Artikel Jurnal
Investigating the Role of A20 in Respiratory Syncytial Virus Immunopathogenesis in a BALB/c Mouse Model
ABSTRACT Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory tract infections in children and the elderly worldwide. RSV pathogenesis is largely driven by exaggerated host immune responses that result in lung injury. In this study, we examined the role of A20…
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Artikel Jurnal
Cycle Threshold (Ct) Value Trends in COVID‐19: Analyzing Gender, Age, and Severity Factors Across Major Waves in India
ABSTRACT Objectives This study investigates the variations in cycle threshold (Ct) values from RT‐PCR tests across different COVID‐19 waves, age groups, and genders to assess their correlation with viral load, disease severity, and epidemiological indicators in India. Methods We analysed a data set…
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Artikel Jurnal
Integrative Omics Analysis Reveals the Potential Value of CEACAM6 in Pan‐Gastrointestinal Cancers
ABSTRACT Objective Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) is known as a cell adhesion receptor which could regulate proliferation and other signaling in cancer. The role of CEACAM6 in pan‐gastrointestinal cancers remains largely uncharacterized. This study employed multi‐omics…
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Artikel Jurnal
Human Leukocyte Antigen (HLA) and Tumor Immunity: A Critical Link in Cancer Immunotherapy
ABSTRACT Background Malignant tumors pose a serious threat to human health and survival, with profound economic consequences worldwide. Human leukocyte antigens (HLAs), encoded by the human major histocompatibility complex, represent one of the most polymorphic genetic systems and play a vital role…
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Artikel Jurnal
Role of LIGHT in the Inflammatory Mechanisms of Psoriasis via Upregulation of Proliferation and Cytokine Production of Keratinocytes
ABSTRACT Background The pathogenesis of psoriasis is associated with abnormalities in immune pathways. HVEM is known as a receptor of LIGHT (homologous to lymphotoxins, inducible, and competes with HSV glycoprotein D), which is a newly identified member of the TNF superfamily. The expression of…
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