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BMC Pharmacology and Toxicology
Scopus
ISSN 2050-6511 · BMC · 783 artikel di indeks
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Artikel Jurnal
In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia
Abstract Background Administration of poor-quality medications can result in various effects that jeopardize the drugs’ safety and effectiveness. Due to a lack of adequate post-market surveillance studies, making decisions regarding the quality of medicines, including metformin hydrochloride…
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Artikel Jurnal
Myricetin protects against doxorubicin-induced liver damage by modulating oxidative and inflammatory pathways
Abstract Background Doxorubicin (Dox) is a highly effective chemotherapy drug used to treat various cancers. However, its clinical application is limited by liver toxicity, which is mainly caused by oxidative stress, inflammation, and mitochondrial damage. Myricetin, a natural flavonoid present in…
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Artikel Jurnal
Synergistic combination of pirfenidone and paclitaxel suppresses migration and stemness in triple-negative breast cancer: implications of EMT and pluripotency pathways
Abstract Triple-negative breast cancer (TNBC) is an aggressive type of cancer with limited treatment options and high risks of metastasis and recurrence. Growing evidence shows that paclitaxel (PTX), a first-line chemotherapeutic agent in TNBC, may paradoxically promote pro-metastatic features of…
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Artikel Jurnal
Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer
Abstract Background Breast cancer remains a leading cause of cancer-related mortality among women worldwide, highlighting the need for safer multitarget therapies. Genistein (GNT) and Apigenin are plant-derived flavonoids with reported anticancer properties, but their dual mechanisms against key…
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Artikel Jurnal
Development and validation of a nomogram for predicting thrombocytopenia in sepsis patients treated with linezolid
Abstract Background The incidence of thrombocytopenia in sepsis patients treated with linezolid is higher, and the mortality rate is significantly increased. This study aimed to develop and validate a nomogram for predicting thrombocytopenia in sepsis patients treated with linezolid. Methods Data…
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Artikel Jurnal
Integrated network toxicology, molecular docking, and molecular dynamics simulation reveals mechanisms of benzo[a]pyrene-induced pan-cancer
Abstract Background Benzo[a]pyrene (B[a]P), a ubiquitous environmental pollutant, is prevalent in emissions, food products, and tobacco. Although B[a]P’s carcinogenicity is well-established, the common molecular mechanisms underlying its pan-cancer carcinogenesis remain incompletely understood…
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Artikel Jurnal
Impact of aging on the pharmacokinetic profile of everolimus in male mice
Abstract Background Age-related changes in drug-metabolizing enzymes and transporters can alter pharmacokinetics, yet data on everolimus, a widely used mTOR inhibitor, remain limited. This study investigated the pharmacokinetic profile of everolimus in male C57BL/6J mice at three life stages—young…
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Artikel Jurnal
Compound 7 h exerts its anti-oncogenic effects on colorectal cancer cells by inducing death-receptor-mediated apoptosis, promoting DNA damage, and obstructing autophagic flux
Abstract Background and aim Previous research described a catalyst-free, post-Ugi synthesis of two distinct series of highly substituted fused pyrazolo-pyrazines. One of these series demonstrated antitumor activity against colorectal cancer (CRC) cells. However, the precise mechanistic pathways…
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Artikel Jurnal
Investigating the impact of gut microbiota-derived metabolites on benign prostatic hyperplasia using network pharmacology approaches
Abstract Background The gut microecosystem represents the most abundant and complex microbial ecosystem in the human body. Maintaining homeostasis of gut microbiota and their metabolites is essential for human health. As a chronic metabolic disorder, the association between benign prostatic…
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Artikel Jurnal
Mechanistic study of deoxycholic acid in colorectal cancer based on network toxicology and machine learning approaches
Abstract Objective This study aims to explore the mechanistic role of deoxycholic acid (DCA) in colorectal cancer (CRC) through the integration of network toxicology and machine learning approaches. Methods Gene differential expression analysis was first performed using datasets from the GEO…
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Artikel Jurnal
Drug re-purposing to improve outcomes in the management of prostate cancer – aims, outcome measures and design of current phase III trials
Abstract Prostate cancer remains a major cause of cancer morbidity and mortality and is rising in incidence across the world. Although a succession of randomised controlled trials have improved outcomes across all stages of disease, there remain significant clinical challenges and unmet needs…
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Artikel Jurnal
Canadine protects against doxorubicin-induced cardiac and brain injury by inhibiting Oxidative stress
Abstract Background Patients receiving doxorubicin (DOX) chemotherapy are susceptible to cardiac and brain tissue damage, with oxidative stress (OS) as the primary mechanism of injury. The purpose of this research is to identify effective agents to reduce the level of DOX-induced OS in the heart…
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Artikel Jurnal
Preservative-free latanoprost induces meibomian gland dysfunction through inflammatory and oxidative stress pathways
Abstract Purpose This study aimed to investigate the effects of preservative-free latanoprost on meibomian gland function in mice and its possible mechanism. Methods Disproportionality analysis was conducted using the FAERS database to evaluate adverse reaction reports and epidemiological…
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Artikel Jurnal
Exploratory identification of COL1A1 as a potential gene linking endocrine-disrupting chemicals and lung adenocarcinoma: a bioinformatics and machine learning analysis
Abstract Background Endocrine-disrupting chemicals (EDCs) are common environmental pollutants that affect human health. These chemicals have been linked to the development and progression of many types of cancer. However, the mechanism by which EDCs affect the development of lung adenocarcinoma…
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Artikel Jurnal
Decrypting potential mechanisms linking ochratoxin A to hepatocellular carcinoma: an integrated approach combining toxicology, machine learning, molecular docking, and molecular dynamics simulation
Abstract Background Ochratoxin A (OTA), a common food-borne mycotoxin, is a potential human carcinogen, yet the specific molecular mechanisms linking it to hepatocellular carcinoma (HCC) remain unclear. Methods We integrated network toxicology to predict OTA targets and intersected them with HCC…
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Artikel Jurnal
Novel mechanisms of atrazine endocrine disruption: an integrated approach reveals progesterone and glucocorticoid receptor targeting
Abstract Background Atrazine is a widely used herbicide with reported endocrine-disrupting effects, yet the molecular targets and pathway-level mechanisms remain to be fully elucidated. We aimed to build an integrated, hypothesis-generating workflow to prioritize candidate atrazine targets by…
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Artikel Jurnal
Association of elevated linezolid trough concentrations with hyperlactatemia in elderly patients: a multicenter observational study in China
Abstract Background The association between hyperlactatemia (HLA) and linezolid concentrations in elderly patients remains poorly understood. This study aimed to explore the associations among linezolid trough concentrations, HLA, and clinical outcomes in elderly patients. Methods Elderly patients…
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Artikel Jurnal
Assessing the toxicological effects of synthetic musk ketone using the Caenorhabditis elegans model
Abstract Background Synthetic musk ketone (MK) is extensively used in perfumes, cosmetics, and detergents. Due to its high lipophilicity, persistence, and limited removal efficiency in wastewater treatment, MK has been detected in various environmental matrices and human tissues. However, the…
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Artikel Jurnal
Comparative analysis of serious adverse effects of antidiabetic drugs and complications associated with type II diabetes mellitus
Abstract Background Type 2 diabetes mellitus (T2DM) is a major global health problem for which a wide range of antidiabetic medications are available. Adverse effects of antidiabetic medications may negatively affect patients’ health and treatment adherence. In Egypt, limited data are available…
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Artikel Jurnal
Meta-analysis of clinical trials assessing the safety of pharmacological treatments for muscular degeneration in Duchenne muscular dystrophy
Abstract Introduction Currently, there is a lack of meta-analysis providing precise incidence estimates of adverse drug reactions (ADRs) and associated risk differences (RDs) linked to pharmacological treatments for muscle degeneration in Duchenne Muscular Dystrophy (DMD). Methods A systematic…