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Biomarker Research
Scopus
ISSN 2050-7771 · BMC · 905 artikel di indeks
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Artikel Jurnal
Soluble cytokines enhance risk prediction across all stages of classical Hodgkin lymphoma
Abstract Classical Hodgkin lymphoma (cHL) is a heterogeneous malignancy with favorable outcomes, but accurate prognostic stratification remains challenging, particularly across all disease stages. Traditional risk models are focused on advanced stages and do not account for tumor microenvironment…
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Artikel Jurnal
miR-22-Galectin-1 as an integral signaling axis in regulating metabolism and immunity in HCC
Abstract Background While miR-22 is a suppressor of hepatocellular carcinoma (HCC), galectin-1 (Gal-1) serves as a HCC biomarker. Our previous studies have shown the effectiveness of miR-22 gene therapy and silencing Gal-1 as two potential novel options in treating HCC in preclinical mouse models…
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Artikel Jurnal
Unlocking the power of extracellular vesicles: multi-omics integration for cancer biomarker discovery
Abstract The search for reliable cancer biomarkers is increasingly driven by the need for non-invasive tools that can monitor tumor dynamics in real time. Extracellular vesicles (EVs) are a heterogeneous family of nanoparticles secreted by almost all cell types under physiological and pathological…
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Artikel Jurnal
Single-cell RNA sequencing unveils enhanced antitumor immunity in colorectal cancer with PD-1 blockade and LINC00673 deletion
Abstract Background Most colorectal cancers are resistant to immune checkpoint inhibitors due to an immunosuppressive tumor microenvironment. LINC00673, previously classified as a long non-coding RNA, has been implicated in tumor progression, but its role in antitumor immunity remains poorly…
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Artikel Jurnal
Machine learning-driven proteomics classifier deciphers tumor origins of primary and metastatic squamous cell carcinomas
Abstract Squamous cell carcinoma (SCC) occurs across multiple organs with highly similar histology, making the diagnosis of SCC of unknown primary (SCCUP) particularly challenging. To address this, we established a machine learning–based 39-protein biomarker classifier (39PBC) trained on proteomic…
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Artikel Jurnal
Peripheral blood biomarkers for predicting response to PD-1/PD-L1 inhibitors
Abstract Though programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) inhibitors have revolutionized cancer treatment, predicting their therapeutic efficacy largely depends on biomarkers obtained through invasive procedures, which present challenges, particularly for…
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Artikel Jurnal
Gene-body DNA methylation of ONECUT2 predicts its expression and prostate cancer aggressiveness in needle biopsies
Abstract Background ONECUT2 is a lineage plasticity driver and therapeutic target in aggressive prostate cancer (PCa). This study investigated whether ONECUT2 gene-body DNA methylation regulates its expression and assessed its potential as a biomarker in clinical specimens. Methods We analyzed…
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Artikel Jurnal
Stratifying high-risk prediabetes clusters using blood-based epigenetic markers
Abstract Background Previously, we identified six prediabetes clusters, three at moderate and three at high-risk for type 2 diabetes and/or complications. While this novel classification could enable earlier and improved disease prevention, it relies on intensive clinical phenotyping. Here, we…
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Artikel Jurnal
Evaluation of Epstein–Barr virus DNA methylation and load in saliva in the management of individuals at high risk of nasopharyngeal carcinoma
Abstract Background The current Epstein–Barr virus (EBV) antibody-based screening strategy for nasopharyngeal carcinoma (NPC) has been used for years. However, its low positive predictive value (PPV) often leads to unnecessary diagnostic procedures. Thus, further triage strategies are needed…
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Artikel Jurnal
Lactate-lactylation in tumor angiogenesis and progression: mechanisms, biomarker potential, and therapeutic implications
Abstract Tumor growth and metastasis are critically dependent on the tumor vasculature, which provides essential nutrients and oxygen. Metabolic reprogramming—a hallmark of cancer—drives aggressive progression in solid tumors and is characterized by excessive lactate production. Beyond its role as…
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Artikel Jurnal
Isolation and typing techniques for circulating tumor cells
Abstract Circulating tumor cells (CTCs) are tumor cells that detach from primary tumors or metastatic sites and enter the peripheral blood. As an important biomarker for liquid biopsy, their detection and analysis have offered a promising avenue in early diagnosis, treatment response monitoring…
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Artikel Jurnal
In vivo engineering of CAR-T cells: delivery strategies and clinical translation
Abstract Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment landscape for hematologic malignancies. Nonetheless, its broad clinical adoption is constrained by the logistical, financial, and safety burdens associated with ex vivo cell manufacturing. In vivo CAR-T…
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Artikel Jurnal
Targeting YAP1-CD70 axis potentiates the efficacy of anti-PD-1 therapy in prostate cancer
Abstract The mechanisms by which prostate cancer (PCa) evades anti-tumor immunity and the immune checkpoint blockade (ICB) response are poorly understood. Yes-associated protein 1 (YAP1) activation is a common feature in PCa. However, to date, there is no direct evidence regarding the effect of…
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Artikel Jurnal
Comparative analysis of microRNA expression in serum and plasma in patients screened for BRCA1 or BRCA2 mutations
Abstract MicroRNA-based biomarkers hold promise for precision oncology, but standardization and pre-analytical variability remain barriers to clinical use. We performed a technical study to assess how the type of biological material (plasma, serum) and quantification (miRNA-seq, RT-qPCR) method…
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Artikel Jurnal
Spatial multi-omics mapping of tumor microanatomy dynamics following radiotherapy combined with targeted-immunotherapy in hepatocellular carcinoma
Abstract Remodeling of the tumor microenvironment (TME) under therapeutic pressure is a critical determinant of treatment response and resistance in hepatocellular carcinoma (HCC). Triple-combination therapy integrating targeted agents, immune checkpoint inhibitors, and radiotherapy (T+I+R) has…
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Artikel Jurnal
Emerging roles of circular RNAs and enhancer RNAs: new insights into the development and management of neurodegenerative disorders
Abstract Neurodegenerative disorders involve the gradual breakdown of neurons, leading to problems with thinking, movement, and mental health. More evidence is emerging about the important roles of non-coding RNAs (ncRNAs). CircRNAs are a type of ncRNA formed through back-splicing and are widely…
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Artikel Jurnal
Multi-omics profiling reveals intrathymic triggers and novel biomarkers in thymoma-associated myasthenia gravis
Abstract Background The pathogenic mechanisms through which thymoma induces myasthenia gravis (MG) remain incompletely understood. While MG pathogenesis involves neuromuscular junction defects and peripheral immune dysregulation, the specific contribution of thymoma microenvironment is poorly…
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Artikel Jurnal
RBM10 modulation of circRNA biogenesis contributes to its tumor suppressor role in lung adenocarcinoma
Abstract Circular RNAs (circRNAs) are emerging regulators in cancer biology, yet the mechanisms underlying their biogenesis remain incompletely defined. RBM10, a splicing regulator frequently mutated in lung adenocarcinoma (LUAD), modulates RNA processing, but its involvement in circRNA regulation…
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Artikel Jurnal
Migrasomes: a journey from biogenesis to multifaceted roles in health and disease
Abstract Migrasomes are newly identified extracellular organelles that form on the retraction fibers of migrating cells. Characterized by their pomegranate-like, membrane-bound structure, they encapsulate diverse molecular cargo, including proteins, lipids, RNA, and even damaged mitochondria. The…
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Artikel Jurnal
Mitochondrial DNA mutations and intercellular mitochondrial transfer in cancer: mechanisms, biological effects, and clinical potential
Abstract Mitochondrial DNA (mtDNA) mutations are frequently detected in tumor cells and represent a distinctive aspect of cancer genomics. Common types of mtDNA alterations include single nucleotide variants, insertions and deletions, and copy number changes. These mutations often result in a range…