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Journal of Intensive Care
Scopus
ISSN 2052-0492 · BMC · 722 artikel di indeks
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Artikel Jurnal
Severe community-acquired pneumonia: an integral approach
Abstract Background Severe community-acquired pneumonia represents the most critical manifestation of pneumonia acquired outside the hospital and remains a major cause of intensive care admission and death worldwide. It is frequently complicated by acute respiratory failure, circulatory shock, and…
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Artikel Jurnal
Association between antithrombin levels and prognosis in patients with sepsis: a retrospective cohort study based on the MIMIC-IV and MIMIC-III databases
Abstract Background Sepsis is a critical determinant of mortality in critical patients. Antithrombin (AT) plays a pivotal role as a serine protease inhibitor with dual anticoagulant and anti-inflammatory functions, yet its precise role in prognostic stratification remains undefined. This study…
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Artikel Jurnal
Sodium bicarbonate for “metabolic acidosis”: an illustration of the Goodhart’s law
Abstract Background Correction of “metabolic acidosis” by sodium bicarbonate is a common practice in intensive care unit or operating room. The physiological rationale underlying its use relies on the potential harmful hemodynamics effects of prolonged low extracellular pH. Main text Evidence…
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Artikel Jurnal
Extracorporeal membrane oxygenation support for tropical infections: a scoping review
Abstract Background Extracorporeal membrane oxygenation (ECMO) for infectious causes of refractory cardiopulmonary failure is established as appropriate therapy in high-income countries. Its use in low- and middle-income nations for tropical infections is not well-studied, however, perhaps because…
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Artikel Jurnal
Inhaled nitric oxide for acute respiratory distress syndrome in adults: a systematic review and meta-analysis
Abstract Background Although inhaled nitric oxide (iNO) is used as a rescue therapy in patients with acute respiratory distress syndrome (ARDS), its impact on patient-centered outcomes remains uncertain. To address this gap, we conducted a systematic review of randomized controlled trials (RCTs) to…
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Artikel Jurnal
Exploratory characterization of dynamic soluble programmed death-ligand 1 trajectories and their association with mortality in critical coronavirus disease 2019
Abstract Background Persistent immune checkpoint activation is a recognized feature of critical coronavirus disease 2019 (COVID-19). However, the temporal behavior and clinical utility of soluble programmed death-ligand 1 (sPD-L1) remain unclear. We investigated the longitudinal changes in sPD-L1…
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Artikel Jurnal
Diagnostic accuracy of tests for assessing readiness for liberation from mechanical ventilation in adults: an overview of reviews
Abstract Objectives To summarize the evidence on the accuracy of tests evaluating readiness for liberation from mechanical ventilation in the adult population. Materials and methods Searches were conducted in MEDLINE, Embase, CENTRAL, and CINAHL, with additional publications identified through…
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Artikel Jurnal
Discontinuation of the development of remimazolam for ICU sedation in Japan: background and rationale
Abstract Remimazolam, an ultra-short-acting benzodiazepine rapidly metabolized by carboxylesterase-1, was developed as a promising alternative for ICU sedation. It was anticipated to overcome the unpredictable accumulation associated with midazolam and the hemodynamic/metabolic risks of propofol…
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Artikel Jurnal
Culture, ethics and clinical practice for intensivists managing end of life care: an Australian perspective
Abstract Death and dying are significant and impactful, for individuals, families and broader society. For clinical teams working in the intensive care unit (ICU), caring for a dying patient and supporting their family are an important part of their professional role. Australian ICU practice has…
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Artikel Jurnal
Effects of two ventilator-weaning methods on lung volume and ventilation distribution by electrical impedance tomography in post-cardiac surgery patients: a prospective cohort study
Abstract Background The effect of different spontaneous breathing trial (SBT) methods on lung volume and ventilation distribution has not been well clarified in post-cardiac surgery patients. Methods In this prospective observational study, patients underwent 30 min of pressure-support ventilation…
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Artikel Jurnal
Outcomes of combined carbazochrome sodium sulfonate plus tranexamic acid therapy versus tranexamic acid monotherapy in traumatic brain injury: a retrospective cohort study in Japan
Abstract Background Traumatic brain injury (TBI) is a major public health concern associated with substantial morbidity and mortality. In Japan, carbazochrome sodium sulfonate (CSS) is widely used, often in combination with tranexamic acid (TXA), for the management of various types of bleeding…
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Artikel Jurnal
Optimizing infection management after cardiac arrest: addressing diagnostic uncertainty and therapeutic dilemmas—a narrative review
Abstract Infections are frequent after cardiac arrest and materially affect post-ICU care and outcomes. Diagnostic uncertainty is heightened by post-cardiac arrest syndrome (PCAS)—hypoxic–ischemic brain injury, myocardial dysfunction, systemic ischemia–reperfusion injury, and immune…
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Artikel Jurnal
Safety and efficacy of remimazolam in critical illness
Abstract Sedation is essential in intensive care units (ICUs) for invasive procedures and mechanical ventilation; however, commonly used agents are limited by hemodynamic instability, delayed recovery of consciousness, and delirium. Remimazolam, an ultra-short-acting benzodiazepine, introduced in…
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Artikel Jurnal
Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial
Abstract Background Nutrition therapy is essential in critically ill patients, yet large randomised trials have shown inconsistent results regarding the effect of an evidence-based feeding protocol. The NEED trial showed a feeding protocol could effectively promote delivery of enteral nutrition…
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Artikel Jurnal
A hybrid multi-criteria decision-making framework for prioritising clinical determinants of medical futility in the intensive care unit
Abstract Determinations of medical futility in the intensive care unit (ICU) are high-stakes, ethically charged, and clinically variable. Contemporary literature increasingly frames such situations as potentially inappropriate treatment (PIT), particularly when physiologically feasible…
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Artikel Jurnal
Pathogen-oriented mNGS is not equivalent to microbiome profiling: interpreting BALF mNGS diversity in ARDS
Abstract Gao et al. provide valuable data-linking bronchoalveolar lavage fluid metagenomic next-generation sequencing with inflammatory subphenotypes of acute respiratory distress syndrome. We highlight three issues relevant to interpretation: an apparent inconsistency concerning exclusion of…
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Artikel Jurnal
Diagnostic performance of package insert-based screening for potential drug–drug interactions in ICU patients receiving injectable medications: a retrospective diagnostic accuracy study using Lexi-Interact as the comparator in Japan
Abstract Background No established gold standard exists for identifying potential drug–drug interactions (pDDIs). In Japan, package inserts are commonly used for pDDI screening in clinical practice, whereas internationally curated databases such as Lexi-Interact serve widely as clinical decision…