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BMJ Open Respiratory Research
Scopus
ISSN 2052-4439 · BMJ Publishing Group · 1,520 articles in the index
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Economic evaluation of single-inhaler triple therapy for chronic obstructive pulmonary disease in Thailand
Introduction Single-inhaler triple therapy (SITT) is known to be a cost-effective intervention for chronic obstructive pulmonary disease (COPD)in Western countries, but there is no such evidence for resource-limited countries. This study aimed to evaluate the cost-utility of SITT compared with…
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Journal Article Full text
Functional respiratory imaging reveals early structural and functional airway responses to benralizumab in severe eosinophilic asthma
Background Benralizumab improves outcomes in severe eosinophilic asthma (SEA). We aimed to evaluate early effects of benralizumab on airway pathophysiology using functional respiratory imaging (FRI).Methods In this prospective, single-arm study, 20 adults with SEA underwent CT at baseline, 4 and 12…
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Journal Article Full text
Mortality trends in chronic obstructive pulmonary disease in 27 countries within Europe from 2011 to 2021
Background Chronic obstructive pulmonary disease (COPD) incurs significant mortality worldwide. Less is known about the burden in the last decade across Europe. We report trends and variations in mortality for patients with COPD across 27 European countries from 2011 to 2021.Methods COPD mortality…
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Journal Article Full text
Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial—investigating effects of a 12-week yoga intervention for adults with cystic fibrosis
Introduction Yoga is an emerging exercise choice for people with cystic fibrosis (CF), but evidence of its effect in this population is scarce, with a recent systematic review advocating for further research. Yoga Outcomes Get Assessed in CF (YOGA-CF) is a real-world multicentre randomised…
Also available at: DOAJ
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Journal Article
Treatment pathways of lung cancer patients in the Czech Republic: insights from administrative claims data
Introduction A patient pathway is an evidence-based tool that details the phases of care with the aim of increasing the effectiveness and efficiency of patient care. We describe diagnostic and treatment pathways and related overall survival (OS) of non-small cell lung cancer patients.Methods This…
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Impulse oscillometry and traditional pulmonary function testing: correlation, advances and clinical implications
Impulse oscillometry system (IOS) is an effort-independent pulmonary function testing technique that assesses respiratory system mechanics during tidal breathing and has gained increasing interest as a complementary modality to traditional pulmonary function tests (PFTs), while its physiological…
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Journal Article
Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury
Background While delivery of supplemental oxygen is a life-saving therapy, exposure to high oxygen, called hyperoxia, leads to increased intensive care unit mortality. Hyperoxia induces oxidant-mediated acute lung injury (ALI) and pulmonary cell death, called hyperoxic ALI (HALI). Elucidating…
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Innovative Inflammatory Burden Index for identification of high mortality risk in patients with pulmonary embolism: a large retrospective cohort study
Background The prognostic significance of systemic inflammation in pulmonary embolism (PE) remains unclear. This study aimed to evaluate the predictive value of a novel Inflammatory Burden Index (IBI) for long-term mortality in patients with acute PE.Methods A total of 1642 patients with acute PE…
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Association of life’s essential 8 with chronic respiratory disease mortality and lung health: a national cohort study
Background This study aims to evaluate the association of Life’s Essential 8 (LE8) with chronic lower respiratory disease (CLRD)-specific mortality and impaired lung health outcomes.Methods This population-based cohort study used data from the National Health and Nutrition Examination Survey…
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Exacerbation-related burden in patients with severe asthma in South Korea: a population-based cohort study
Background The burden of severe asthma due to asthma exacerbation is increasing. However, recent studies identifying exacerbation-related disease burden among patients with severe asthma in South Korea are lacking.Objective To evaluate the burden of asthma exacerbations in patients with severe…
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Journal Article
COPD and vitamin K antagonism: a cohort study of 1-year all-cause mortality and risk of hospitalisation due to a severe exacerbation
Background Vitamin K, through its role in the vitamin K-dependent activation of matrix-GLA-protein, has been suggested to have a lung-protective effect, though the mechanism is unknown. Chronic obstructive pulmonary disease (COPD) patients treated with vitamin K antagonists (VKAs) may lose this…
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Journal Article
Improving the management and outcomes of preschool wheeze: protocol of a prospective multicentre cohort study
Introduction Preschool wheeze and asthma are associated with substantial morbidity and impaired future lung function. Yet, wheeze is unreliably reported with high disagreement (>50%) between parental and physician observations. Objectively defining wheeze and its reversibility could enable an…
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How doctors present treatment options in advanced lung cancer consultations: a conversation analytic study
Background To facilitate shared decision-making (SDM), it is important that doctors clearly present the decision to be made and the available treatment options to the patient. This study explored how treatment options after first-line therapy were presented in advanced lung cancer…
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Journal Article
Associations between breathlessness and individuals’ satisfaction with sexual life: a nationally representative internet survey
Introduction Sexual life is important for many people and may be limited by breathlessness. We evaluated associations between breathlessness and individuals’ perceived satisfaction with sexual lives and explored mediating factors in this relationship.Methods A cross-sectional, online…
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Societal and personal financial burden of severe asthma and impact of biologic therapy: a 19-year nationwide cost analysis
Introduction Severe asthma incurs a financial burden on both patients and societies. However, little is known about the long-term financial burden and impact of biologic therapy.Methods All Danish adults initiating biologic therapy for severe asthma between 2016 and 2020 were included and followed…
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Pulmonary function and airflow limitation in bronchiectasis: a case-control study of two independent cohorts
Background Bronchiectasis is a respiratory disease structurally characterised by irreversible airway dilatation. Functional impairments are also implicated in bronchiectasis, but the detailed changes in pulmonary function and the impact of clinical factors are yet to be examined. We analysed…
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Understanding real-world effectiveness of nirsevimab and the characteristics of breakthrough RSV infections: a study protocol of individual-participant-level data meta-analysis (the GEMINI study)
Introduction The recent rollout of nirsevimab across multiple countries represents an important advancement in respiratory syncytial virus (RSV) prevention. However, real-world evidence on how its effectiveness varies with infant age and time since administration, and on the characteristics of…
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Phase 2a randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of londamocitinib (AZD4604) two times per day for 12 weeks in adult patients with moderate-to-severe asthma uncontrolled on medium-high-dose ICS-LABA
Introduction Asthma is a heterogeneous condition and affected individuals show variable responses to available medications. An unmet need exists for add-on therapies that target novel molecular pathways, before patients escalate to biologics. Janus kinase 1 (JAK1) is implicated in multiple…
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