1.221 hasil
Menampilkan 1–20 · 0,39 detik · RSS
BMJ Open Diabetes Research & Care
Scopus
ISSN 2052-4897 · BMJ Publishing Group · 1.221 artikel di indeks
-
Artikel Jurnal Teks lengkap
Age and sex differences in diabetic ketoacidosis outcomes in type 1 diabetes: a national cohort study
Background Despite therapeutic advances, diabetic ketoacidosis (DKA) hospitalizations continue to increase. The role of demographic factors, including age and sex in the outcomes of DKA remains underexplored. We aimed to investigate the interaction between age and sex on clinical outcomes, resource…
Juga tersedia di: DOAJ
-
Artikel Jurnal
Association of genetic variation with age at diagnosis in type 1 diabetes
Introduction Type 1 diabetes is an autoimmune disease with a strong genetic basis. The aim of this study was to identify additional single-nucleotide polymorphisms (SNPs) for type 1 diabetes age at diagnosis and to replicate previously identified loci.Research design and methods Meta genome-wide…
-
Artikel Jurnal
Effects of benfotiamine treatment over 12 months on morphometric, neurophysiological and clinical measures in type 2 diabetes patients with symptomatic polyneuropathy: a randomized, placebo-controlled, double-blind clinical trial (BOND study)
Introduction Shunting of glycolytic intermediates into the pentose phosphate pathway via transketolase activation by benfotiamine has been suggested to protect from hyperglycemia-induced microvascular damage, but the long-term effects of benfotiamine on diabetic sensorimotor polyneuropathy (DSPN)…
-
Artikel Jurnal
Associations of body weight and COVID-19 with autoimmunity in pediatric new-onset type 1 diabetes: results from the prospective DPV registry
Introduction This study analyzed the effects of the COVID-19 pandemic and body weight on islet and endocrine autoimmunity in children with type 1 diabetes (T1D).Research design and methods Data from 11 973 children and adolescents aged 0.5 to <18 years with new-onset T1D (2015–2023) from the…
-
Artikel Jurnal
Zero Dollar Drug Copay program improves antidiabetic medication adherence and medication use patterns among Blue Cross and Blue Shield of Louisiana members with diabetes in Louisiana
Objective Blue Cross and Blue Shield of Louisiana (BCBSLA) launched a zero-dollar co-pay (ZDC) pharmacy benefit on July 1, 2020, to reduce cost-related barriers to diabetes medications. This study evaluated the program’s effect on antidiabetic medication adherence and use patterns.Research Design…
-
Artikel Jurnal
Serum soluble ASGR1 concentration is elevated in patients with metabolic dysfunction-associated steatotic liver disease and is associated with adiponectin
Introduction Current studies have shown that the asialoglycoprotein receptor 1 (ASGR1) is involved in glycolipid metabolism and is associated with systemic insulin resistance. This study aims to explore the correlation between serum soluble ASGR1 (sASGR1) levels and metabolic dysfunction-associated…
-
Artikel Jurnal
Cardiovascular autonomic dysfunction is linked with arterial stiffness across glucose metabolism: the Maastricht study
Objective To ascertain the cross-sectional association between cardiovascular autonomic dysfunction and arterial stiffness across glucose metabolism status.Research design and methods We performed a cross-sectional analysis of participants of the Maastricht study. Cardiovascular autonomic function…
-
Artikel Jurnal
Longitudinal changes in epigenetic age acceleration prior to type 1 diabetes onset in the Diabetes Autoimmunity Study in the Young (DAISY)
Background Type 1 diabetes is believed to be associated with early genetic and environmental stressors. Epigenetic age acceleration (EAA) is also associated with environmental stressors and the pathogenesis of many chronic diseases. This study explored longitudinal changes in EAA among individuals…
-
Artikel Jurnal
Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes
Introduction Diabetic ketoacidosis (DKA) occurs frequently in children with type 1 diabetes (T1D). The inflammatory response to DKA may play a role in complications, but the inflammatory pattern is not well characterized. We aimed to describe the inflammatory profile during and after DKA.Research…
-
Artikel Jurnal
Comparative safety of sulfonylurea therapies on cardiovascular and severe hypoglycemia outcomes among adults with type 2 diabetes and moderate cardiovascular risk: a target trial emulation
Introduction To examine within-class sulfonylurea safety, we compared risks of major adverse cardiovascular events (MACE) and severe hypoglycemia among adults with type 2 diabetes (T2D) and moderate cardiovascular risk following sulfonylurea initiation.Research design and methods We conducted a…
-
Artikel Jurnal
Management and outcomes of people presenting with new diabetes-related foot infections: a prospective observational study from Australia and New Zealand
Introduction Infections precede nearly all hospitalizations and amputations related to diabetes-related foot disease. Focusing on antibiotic management, we aimed to report the outcomes of people presenting with a new diabetes-related foot infection (DFI).Research design and methods In this…
-
Artikel Jurnal
Feasibility and cost-effectiveness of at-home self-sampling screening for type 2 diabetes: a pilot screening study in Denmark
Objective The increased use of HbA1c as a diagnostic criterion, novel methods to collect and store blood samples as well as the quality of national registers enable screening targeted individuals, who are not screened opportunistically. The study evaluates whether screening for type 2 diabetes…
-
Artikel Jurnal
Association of weekday sleep duration and estimated glucose disposal rate: the role of weekend catch-up sleep
Background Existing studies have demonstrated a close association between sleep duration and insulin resistance (IR), diabetes, and related metabolic disorders. The estimated glucose disposal rate (eGDR) serves as a reliable marker of IR. This study examined the association between weekday sleep…
-
Artikel Jurnal
Economic evaluation of NT-proBNP testing plus standard clinical assessment versus standard clinical assessment alone for the prevention of heart failure in older adults with type 2 diabetes
Introduction N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing for early heart failure (HF) detection in asymptomatic older adults with diabetes in the USA remains limited despite guideline recommendations. This study evaluated the cost-effectiveness of incorporating NT-proBNP testing…
-
Artikel Jurnal
Selective glomerular hypofiltration syndrome: a novel renal phenotype associated with cardiovascular disease and adverse outcomes in diabetic kidney disease
Introduction Selective glomerular hypofiltration syndrome (SGHS), defined by a low ratio of estimated glomerular filtration rate using cystatin C (eGFRcys) to estimated glomerular filtration rate using creatinine (eGFRcr), has emerged as a novel kidney dysfunction phenotype. Its role in diabetic…
-
Artikel Jurnal
Associations of Life’s Essential 8 cardiovascular health score with prevalent microvascular complications stratified by sex and menopausal status in Chinese adults with type 2 diabetes: a cross-sectional study
Objective To assess the association between Life’s Essential 8 (LE8) cardiovascular health score and prevalent microvascular complications in Chinese adults with type 2 diabetes mellitus (T2DM) and to explore whether this association differed by sex and menopausal status.Research design and methods…
-
Artikel Jurnal
Resetting the glucose sensor: dorzagliatin and the evolution of glucokinase activation in diabetes therapy
The progressive decline in functional β-cell mass represents a fundamental, unmet challenge in type 2 diabetes (T2DM) management. Dorzagliatin (HMS5552), a fourth-generation, dual-acting, and glucose-dependent glucokinase activator (GKA), offers a distinct mechanistic approach that aims to move…
-
Artikel Jurnal
Reduced circulating Mig-6 levels are associated with dysglycemia in metabolic dysfunction associated steatotic liver disease (MASLD)
Introduction Type 2 diabetes mellitus (T2D) accelerates the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to hepatic fibrosis, and a subset of MASLD subjects has T2D. Identification of molecular mediators linking T2D and MASLD progression remains unmet. Studies…
-
Artikel Jurnal
Mapping shared genetic determinants of eGFR and albuminuria with a focus on type 2 diabetes: a large-scale European study
Background and hypothesis Chronic kidney disease (CKD) is a global health and economic burden, particularly among individuals with type 2 diabetes (T2D). According to Kidney Disease: Improving Global Outcomes guidelines, key CKD indicators include urine albumin-creatinine ratio (UACR) and estimated…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.