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Lupus Science and Medicine
Scopus
ISSN 2053-8790 · BMJ Publishing Group · 1.819 artikel di indeks
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Artikel Jurnal Teks lengkap
Sites of skin inflammation recurrence in patients with SLE: an analysis of clinical trial data
Juga tersedia di: DOAJ
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Artikel Jurnal
Real-world experience with belimumab-based triple therapy in proliferative lupus nephritis: data from the BEL-SPAIN Registry
Objective To evaluate the efficacy, safety and predictive factors of belimumab (BEL)-based triple therapy in proliferative lupus nephritis (LN) in real-world settings.Methods We conducted a multicentre, retrospective study including patients with proliferative LN (new-onset or relapsing) who…
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Artikel Jurnal
Trajectories of long-term eGFR and proteinuria in lupus nephritis: a real-world biopsy-proven cohort study
Background The long-term trajectories of estimated glomerular filtration rate (eGFR) and their relation to early proteinuria trajectories in biopsy-proven lupus nephritis (LN) are unclear. We aimed to identify eGFR trajectories and examine their association with 24-hour urine protein (24hUP)…
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Artikel Jurnal
Alterations in the DTI-ALPS index and choroid plexus volume as brain–immune interfacing indicators in neuropsychiatric lupus erythematosus with inflammatory phenotype
Objectives This study aims to compare the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, choroid plexus (CP) volume and perivascular space (PVS) volume across different subtypes of neuropsychiatric systemic lupus erythematosus (NPSLE) in order to gain a deeper…
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Artikel Jurnal
Balancing stringency and feasibility: comparative value of disease-activity measures to predict pregnancy outcomes in systemic lupus erythematosus
Objective To compare preconception disease-activity indices—systemic lupus erythematosus Disease Activity Score low disease activity (SLE-DAS LDA), lupus low disease activity state (LLDAS) and SLE-DAS remission—with Definitions of Remission in SLE (DORIS) remission in predicting adverse maternal…
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Artikel Jurnal
Telitacicept versus belimumab for the treatment of systemic lupus erythematosus: a network meta-analysis and cost-effectiveness analysis
Objectives Both telitacicept and belimumab are approved for treating active systemic lupus erythematosus (SLE) in China. However, the economic value of these two drugs is unclear. Therefore, this study aims to evaluate the cost-effectiveness of telitacicept versus belimumab in SLE from the…
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Artikel Jurnal
Malignancies in lupus nephritis: a retrospective cohort study on epidemiology and risk factors
Objectives This study aimed to evaluate the epidemiology and predisposing factors for malignancy in lupus nephritis (LN).Methods This retrospective cohort study included 290 patients diagnosed with LN from 1969 to 2023. Demographic and clinical variables were analysed using the Mann-Whitney U test…
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Artikel Jurnal
Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun
Objective SLE is a multifaceted chronic inflammatory disorder characterised by a dysregulated immune response that involves various organ systems, with significant implications stemming from the type I interferon (IFN) signalling pathway in its pathogenesis. This study aimed to elucidate the…
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Artikel Jurnal
Lupus Nexus: developing a prospective registry, biorepository and data exchange platform to foster global collaborations, accelerate research innovation and advance precision medicine in lupus
Introduction SLE remains a disease of high unmet medical need. Protean manifestations and the lack of clear understanding of aetiology, pathogenesis and disease subgroups make it difficult to develop and employ targeted therapeutic approaches. Community-wide access to a longitudinal, highly curated…
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Artikel Jurnal
Biomarker-stratified efficacy and safety of biologics in systemic lupus erythematosus: a systematic review and meta-analysis
Objective Biologics for systemic lupus erythematosus (SLE) demonstrate variable treatment responses across trials. We evaluated baseline biomarkers as predictors of response to guide personalised therapy selection.Methods We searched PubMed, OVID, Scopus, Cochrane and PsycInfo (January 2000–October…
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Artikel Jurnal
Serum IL-2 levels are associated with disease activity and related to dyslipidaemia and the immunological profile in systemic lupus erythematosus
Introduction Systemic lupus erythematosus (SLE) is an autoimmune disorder characterised by multisystem involvement, frequently including cardiovascular manifestations. Interleukin 2 (IL-2), a key cytokine in immune regulation, plays a pivotal role in maintaining tolerance by promoting regulatory T…
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Artikel Jurnal
Clinical utility and performance of anti-C1q antibodies for SLE: comparative analysis of three different assays
Objective Despite the reported clinical significance of anti-C1q immunoglobulin G autoantibodies (anti-C1q) for SLE and the development of anti-C1q commercial kits, their performance characteristics in routine patient evaluation remain poorly defined.Methods In this cross-sectional study, an…
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Artikel Jurnal
Left Ventricular Mass Index as an independent predictor of major adverse cardiovascular and cerebrovascular events in patients with SLE
Background Although the increased risk of cardiovascular disease in patients with SLE is well-documented, effective tools for risk stratification remain elusive. This study sought to explore the prognostic value of echocardiographic parameters for major adverse cardiovascular and cerebrovascular…
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Artikel Jurnal
Serum S100A8 as a potential biomarker for diagnosis of antiphospholipid syndrome and risk stratification among aPL carriers
Background Current diagnosis of antiphospholipid syndrome (APS) relies on antiphospholipid antibodies (aPL) testing, but false-positive aPL results and asymptomatic aPL carriers pose significant clinical challenges. The importance of S100A8 in thrombosis has been demonstrated, yet its potential…
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Artikel Jurnal
Statin therapy in systemic lupus erythematosus: a meta-analysis of disease activity and inflammatory biomarkers
Objective Dyslipidaemia in systemic lupus erythematosus (SLE) contributes to pathogenesis and cardiovascular risk. The effect of statin therapy on SLE disease activity remains controversial. This meta-analysis systematically evaluates the impact of statins on SLE activity and inflammatory…
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Artikel Jurnal
Induction treatment of lupus nephritis: to pulse or not to pulse? Whether ’tis nobler to universally or selectively prescribe
Objective Although treatment guidelines recommend pulse steroids, induction treatment of lupus nephritis (LN) varies significantly among providers. This paper aims to explore evidence that intravenous pulse provides pharmacological benefits along with improved clinical efficacy without greater…
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Artikel Jurnal
Intrathecal injection of rituximab inhibits microglial M1 polarisation to alleviate neuropsychiatric SLE symptoms via the cAMP/PKA/CREB signalling pathway
Objective The objective of this study was to investigate the effects of rituximab (RTX) intrathecal injection on antibody levels in serum and cerebrospinal fluid (CSF), hippocampal tissue and neuronal injury and the behaviour of central neuropsychological lupus erythematosus (cNPSLE) model mice and…
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Artikel Jurnal
Sex-based clinical and immunological differences across lupus erythematosus subtypes: a cross-sectional multicentre study from China
Objective To investigate sex-related differences in clinical and immunological features across lupus erythematosus (LE) subtypes.Methods This cross-sectional analysis, based on the Lupus Erythematosus Multicenter Case–Control Study in Chinese populations (ChiCTR2100048939), included patients with…
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