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Journal of Pharmaceutical Health Care and Sciences
Scopus
ISSN 2055-0294 · BMC · 521 articles in the index
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Journal Article
Clinical outcomes after switching from sulfamethoxazole-trimethoprim to atovaquone due to intolerance in patients with non-HIV Pneumocystis pneumonia: a single-center retrospective study
Abstract Background Atovaquone (Atov), a second-line drug, is used to treat patients with Pneumocystis pneumonia (PCP) who cannot tolerate sulfamethoxazole/trimethoprim (SMX/TMP). However, the efficacy and safety of Atov are based on clinical trials conducted in patients with human immunodeficiency…
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Journal Article
Development and practical validation of BUBBLESS tapping instrument for efficient bubble removal during antibody drug mixing
Abstract Background Antibody drugs play a central role in modern medical treatments, despite their tendency to aggregate under physical stimuli being a major challenge. Generically, these are prone to foaming, and bubble from syringes is typically manually removed by means of tapping. Hence, this…
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Journal Article
Knowledge, attitude and practice towards antimicrobial resistance among final-year undergraduate students in the health sciences at Addis Ababa University, Ethiopia
Abstract Background Globally, antimicrobial resistance (AMR) is a complex and growing public health challenge, primarily driven by the inappropriate use of antimicrobials. Promoting the rational use of these agents is the most effective strategy for preventing AMR. This can be achieved by improving…
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Journal Article
The effect of pharmaceutical supply chain management practice on operational performance: the case of the central clusters and central Ethiopian pharmaceutical supply service
Abstract Background Effective pharmaceutical supply chain management ensures the availability of medicines and improves healthcare, while supply chain integration and transparent sharing of quality information are critical to increasing profitability and performance. However, the Ethiopian…
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Journal Article
Ibuprofen gargle for quality of life and pain improvement in oral lichen planus: randomized crossover and long-term extension phase II study
Abstract Background Oral lichen planus (OLP) is a chronic immune-mediated inflammatory disease of the oral mucosa that frequently causes erosive lesions accompanied by pain, thereby impairing the patient’s ability to eat and drink and their overall quality of life (QOL). Current guidelines…
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Journal Article
Risk factor analysis for ceftriaxone-associated liver dysfunction in older patients
Abstract Background Information on ceftriaxone (CTRX)-associated liver dysfunction in older patients remains limited. This study, investigated the risk factors for CTRX-associated liver dysfunction in patients aged ≥65 years. Methods We conducted a retrospective chart review of the medical records…
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Journal Article
Rhodiola rosea L. roots powder strongly reduces anxiety and corticosterone level induced by chronic stress in a murine model
Abstract Chronic stress disrupts physiological and psychological homeostasis, yet effective therapeutic strategies remain limited. This study investigated the adaptogenic effects of Rhodiola rosea root powder (standardized to 3% salidroside) on stress-induced behavioral and physiological changes in…
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Journal Article
Investigating rituximab-induced infusion-related reactions in patients with non-Hodgkin lymphoma, with a focus on follicular lymphoma: a retrospective observational study
Abstract Introduction The incidence of infusion-related reactions (IRRs) caused by rituximab is very high, and many studies have explored factors related to the onset of IRR; however, most analyses have been conducted on a mixed range of disease indications. This study aimed to investigate…
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Journal Article
Experience-based ambivalence toward medical opioid use among Japanese adults: a nationwide cross-sectional survey using the barriers questionnaire II
Abstract Background Pain is one of the most distressing symptoms in patients with cancer. Although established guidelines now recommend appropriate opioid use, even for mild-to-moderate pain, Japan’s prescription volume remains markedly lower than that of Western countries. Public ambivalence…
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Journal Article
Use of Upadacitinib in elderly patients with IBD: a case series
Abstract Background Upadacitinib (UPA) is a selective Janus kinase (JAK) 1 inhibitor that may rapidly induce and maintain a remission of inflammatory bowel disease (IBD) through potent suppression of cytokine signaling. While a pan-JAK inhibitor has been shown to increase the risk of thromboembolic…
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Journal Article
The impact of pharmacist-led medication therapy management on the efficacy of cancer pain control: a pre-post interventional study
Abstract Background Cancer pain remains a prevalent and debilitating symptom among patients with advanced malignancies, significantly compromising quality of life. While clinical guidelines for pain management exist, real-world challenges such as polypharmacy, poor adherence, and drug-related…
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Journal Article
Placental transfer of third-generation antiepileptic drugs: in vivo lacosamide case study and in vitro investigation of transporter inhibition by lacosamide and perampanel
Abstract Background Antiepileptic drugs must be continually used to control seizures in pregnant people with epilepsy. Lacosamide (LCM) and perampanel (PER) are third-generation antiepileptic drugs that were introduced to clinical practice in 2008 and 2012, respectively. LCM and PER are…
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Journal Article
Troxipide nanosuspensions prevent indomethacin‑induced gastrointestinal lesions in adjuvant-induced arthritis rats
Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for managing inflammatory disorders such as rheumatoid arthritis (RA); however, their long-term use is frequently associated with gastrointestinal (GI) complications, often leading to RA treatment discontinuation. To…
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Journal Article
Trends in Linezolid Prescription in Japan based on National database open Data: implications for the need for therapeutic drug monitoring
Abstract Background Linezolid is an oxazolidinone antibiotic widely used to treat infections caused by resistant Gram-positive bacteria. It has long been regarded as a drug that does not require therapeutic drug monitoring, owing to its limited pharmacokinetic variability. However, recent clinical…
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Journal Article
Serum KL-6 and eGFR predict everolimus-associated KL-6 elevation in heart transplant recipients: a retrospective observational study
Abstract Background Everolimus (EVR), which is widely used in heart transplant recipients, has been associated with drug-induced lung injury. Although EVR-associated lung injury has been reported in patients with malignancies and recipients of other solid organ transplants, its incidence and risk…
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Journal Article
Risk modifiers of immune-related adverse events in patients with NSCLC undergoing immunotherapy: a retrospective cohort study
Abstract Background To investigate immune-related adverse events (irAEs) in patients with non-small cell lung cancer receiving immune checkpoint inhibitor (ICI) therapy, and to identify clinical factors associated with irAE onset, thus supporting safer immunotherapy through effective monitoring…
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Journal Article
Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events
Abstract Background Carbonic anhydrase inhibitors used as antiepileptic drugs promote calcium phosphate stones. Patients with epilepsy often receive vitamin D concurrently, which may increase urinary calcium and stone formation. We analyzed drug-drug interactions to determine if vitamin D…
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Journal Article
Pharmacist-driven antimicrobial stewardship: evolving roles in clinical practice
Abstract Antimicrobial resistance (AMR) poses a major global public health threat. The effective implementation of antimicrobial stewardship (AS) is essential for optimizing antimicrobial use and improving clinical outcomes. In this context, pharmacists play a central role by managing…
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Journal Article
Impact of community pharmacists on improving polypharmacy in elderly outpatients: a community-based intervention study
Abstract Background Polypharmacy, defined as the inappropriate use of multiple concomitant medications, represents a major concern in elderly care and is associated with drug–drug interactions, adverse effects, and poor medication adherence. Previous studies have emphasized the importance of…
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Journal Article
Chemical stability study of diuretics in a concomitant simple suspension with magnesium oxide
Abstract Background A simple suspension method has been widely used in Japan, however, chemical interactions among drugs in co-suspensions have not been fully clarified. Magnesium oxide (MgO), which is frequently prescribed as a laxative, can interact with various drugs. Eplerenone and…