909 results
Showing 1–20 · 0.23 seconds · RSS
npj Biofilms and Microbiomes
Scopus
ISSN 2055-5008 · Nature Portfolio · 909 articles in the index
-
Journal Article
Dietary fiber deficiency exacerbates intestinal inflammation via miR-6240-enriched gut extracellular vesicles
Abstract Emerging evidence underscores the critical role of dietary fiber in maintaining gut homeostasis. While extracellular vesicles (EVs) have recently gained attention as key mediators of host-microbe communication, their functional contribution to fiber deficiency-associated pathologies…
-
Journal Article
Real-time, high-resolution metabolic characterization of live bacteria using label-free optical metabolic imaging
Abstract Label-free optical imaging provides non-invasive, high-speed, high-resolution metabolic characterization of live bacteria with single-cell resolution. Here, we demonstrate the ability of label-free multiphoton autofluorescence microscopy to characterize the fast (between 0 and 30 min)…
-
Journal Article
Gut microbiome composition and function reflect socioeconomic deprivation
Abstract Socioeconomic status (SES) correlates with adverse health outcomes, but the underlying biological mechanisms remain unclear. We examined how area-level deprivation (Townsend Deprivation Index) influences gut microbiome composition and function and whether the gut microbiome mediates the…
-
Journal Article
Harnessing gut microbiota for brain health: protective role of Hungatella hathewayi for post-mTBI cognitive impairment
Abstract Cognitive impairment (CI) following mild traumatic brain injury (mTBI) poses a clinical challenge, with emerging evidence implicating gut microbiota. This study found that mTBI patients who developed CI exhibited decreased Hungatella hathewayi, while those without CI showed an increase…
-
Journal Article
Modeling diet-gut microbiome interactions and prebiotic responses in Thai adults
Abstract The impact of diet on gut microbial metabolism is essential for advancing microbiome-based health interventions. This study introduces a novel systems biology pipeline that integrates genome-scale metabolic models (GSMMs) with Thai dietary intake data to simulate gut microbiome metabolism…
-
Journal Article
Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins
Abstract Renal injury is a common complication of hyperuricemia (HUA), which has been recognized as an independent risk factor for chronic kidney disease (CKD). The gut-kidney axis theory suggests that targeting the gut microbiota may be a potential treatment option for kidney disease. In this…
-
Journal Article
Extracellular vesicles as structured vectors of quorum sensing signals influence aquatic microbial communities
Abstract Quorum sensing (QS) orchestrates collective microbial behaviors and functional acclimatization through chemical communication. However, QS in natural waters is challenged by dilution, alkaline hydrolysis, and enzymatic degradation of freely dissolved autoinducers. Here, we demonstrate that…
-
Journal Article
A novel synbiotic (SCM06) for anxiety and sensory hyperresponsiveness in children with autism spectrum disorder: an open-label pilot study
Abstract Anxiety and sensory hyperresponsiveness are common in children with autism spectrum disorder (ASD), but effective treatments are lacking. Targeting the microbiota-gut-brain axis is a promising strategy. This open-label pilot study evaluated SCM06, a novel synbiotic designed to target…
-
Journal Article
Unraveling the microbial landscape in prostate cancer: pathogenesis to therapy
Abstract Emerging evidence suggests a role of microbiota in prostate cancer, yet this association remains poorly understood. This review systematically examines microbes from the skin, oral cavity, gut, urinary tract, and the prostate cancer microenvironment, summarizing how these communities…
-
Journal Article
Mucosa-associated bacteria and metabolites in inflammatory bowel disease: from inside to insight
Abstract Inflammatory bowel disease (IBD) involves chronic gastrointestinal inflammation with complex etiologies, where gut microbiota and metabolites have emerged as key pathogenic factors. While earlier studies predominantly focused on fecal bacteria, recent research has shifted to…
-
Journal Article
Biofertilizer induces soil disease suppression by activating pathogen suppressive protist taxa
Abstract Given the increasing demand for sustainable agricultural solutions utilizing the microbiome, particularly the use of biofertilizer (BF), it is essential to understand the mode of action and the role of predatory protists, along with their interactions with biocontrol strains and resident…
-
Journal Article
Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene
Abstract Defective intestinal epithelial tight junction (TJ) barrier is a key pathogenic factor of inflammatory bowel disease (IBD). Probiotic bacterial upregulation of intestinal TJ barrier has been shown to prevent the development of intestinal inflammation. However, the mechanism of microbe-host…
-
Journal Article
Enzymes-enhanced antibiotic therapy reduces biofilms to undetectable levels in an implant-associated infection model
Abstract Implant-associated infections caused by biofilm-forming bacteria, such as Staphylococcus aureus, remain a major clinical challenge due to their high tolerance to conventional antibiotic therapies. We report a dual-targeted therapeutic strategy that combines a tri-enzymatic cocktail…
-
Journal Article
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis
Abstract Although disrupted bile acid (BA) homeostasis is implicated in necrotizing enterocolitis (NEC), its role in NEC pathogenesis remains unclear. We revealed that secondary BA accumulation in the ileum with severe NEC induced Paneth cell (PC) loss via the activation of the intestinal farnesoid…
-
Journal Article
Oral microbiota–driven immune modulation along the oral–gut axis: from local signals to systemic inflammation
Abstract The oral–gut axis is a key pathway through which oral microbiota modulate systemic immunity. Oral bacteria and their derivatives, including microbial-associated molecular patterns and extracellular vesicles, can translocate to the gut, evade mucosal defenses, interact with local immune…
-
Journal Article
From leaves to aphid honeydew: the zucchini plants enrich bacterium to recruit natural enemy to resist herbivore attacks
Abstract Plants have evolved intricate defense strategies to combat herbivorous insect attacks, including the production of toxic secondary metabolites and the attraction of natural enemies. While bacterial-mediated direct toxicity in plant defenses has been demonstrated, the ecological mechanisms…
-
Journal Article
Restoration of ethanol-induced Bifidobacterium pseudocatenulatum depletion ameliorates alcohol-associated liver disease
Abstract Alcohol-associated liver disease (ALD), characterized by gut barrier disruption and microbial dysbiosis, is associated with significant depletion of the genus Bifidobacterium in patients, as evidenced by our cohort of 127 subjects. Functional screening revealed B. pseudocatenulatum as a…
-
Journal Article
Shipped and shifted: modeling collection-induced bias in microbiome multi-omics using a tractable fermentation system
Abstract Large-scale, decentralized microbiome sampling surveys and citizen science initiatives often require periods of storage at ambient temperature, potentially altering sample composition during collection and transport. We developed a generalizable framework to quantify and model these biases…
-
Journal Article
Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns
Abstract The human gut microbiota is vital for immune function, metabolism, and resistance to pathogens. Soil-transmitted helminths like Trichuris trichiura can disrupt this microbial community, but the extent and functional significance of these disruptions across diverse regions remain unclear…