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Clinical Diabetes and Endocrinology
ISSN 2055-8260 · BMC · 163 artikel di indeks
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Artikel Jurnal
Bone health in young adults with type 1 diabetes and progressive eGFR decline
Abstract Background Type 1 Diabetes (T1D) is associated with increased risk of fractures, worsened by presence of microvascular complications. This study’s objective is to determine the impact of progressive decline in estimated glomerular filtration rate (eGFR) on bone biomarkers and bone…
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Artikel Jurnal
Application of a validated prognostic plasma protein biomarker test for renal decline in type 2 diabetes to type 1 diabetes: the Fremantle Diabetes Study Phase II
Abstract Background There are scant data relating to prognostic biomarkers for chronic kidney disease (CKD) complicating type 1 diabetes. The aim of this study was to assess the performance of the plasma protein biomarker-based PromarkerD test developed and validated for predicting renal decline in…
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Artikel Jurnal
Comparison of therapeutic effects of N-Acetylcysteine with pregabalin in improving the clinical symptoms of painful diabetic neuropathy: a randomized, double-blind clinical trial
Abstract Objectives Painful diabetic neuropathy (PDN) is highly prevalent and annoyingly in patients with diabetes. The aim of this study was to investigate the effects of oral N-acetylcysteine (NAC) compared to pregabalin in PDN. Methods One hundred two eligible patients with type 2 diabetes and…
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Artikel Jurnal
Unraveling the enigma of sarcopenia and sarcopenic obesity in Indian adults with type 2 diabetes – a comparative cross-sectional study
Abstract Background Sarcopenia and sarcopenic obesity are growing concerns associated with increasing diabetes incidence, but data from Indian diabetic cohorts are limited. This study examined the prevalence and clinical factors associated with sarcopenia and sarcopenic obesity. Methods In this…
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Artikel Jurnal
Social determinants of health and diabetes: using a nationally representative sample to determine which social determinant of health model best predicts diabetes risk
Abstract Objectives Social determinants of health (SDOH) research demonstrates poverty, access to healthcare, discrimination, and environmental factors influence health outcomes. Several models are commonly used to assess SDOH, yet there is limited understanding of how these models differ regarding…
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Artikel Jurnal
Graves disease is associated with increased risk of clinical Alzheimer’s disease: evidence from the Medicare system
Abstract Background Identification of modifiable risk factors for Alzheimer’s Disease (AD) onset is an important aspect of controlling the burden imposed by this disease on an increasing number of older U.S. adults. Graves disease (GD), the most common cause of hyperthyroidism in the U.S., has been…
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Artikel Jurnal
Predictors of lack of glycemic control in persons with type 2 diabetes
Abstract Background Professional guidelines recommend an HbA1c 8.5%). Multivariate logistic regression analysis was performed to assess independent predictors of lack of improvement in glycemic control. Results Out of 2,232 patients who met the inclusion criteria, 1,383 had an improvement in HbA1c…
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Artikel Jurnal
Long-term TNF-alpha therapy for preserving beta cell function in new onset type 1 diabetes: a case report
Abstract Background Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by destruction of pancreatic islet beta-cells. There is significant residual beta-cell function, measured through circulating C-peptide, present at the time of T1D diagnosis but this subsequently decreases with time…
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Artikel Jurnal
Metformin mitigates dementia risk among individuals with type 2 diabetes
Abstract This mini-narrative review explores the relationship between diabetes and dementia, focusing on the potential mitigating role of metformin in reducing cognitive decline among individuals with type 2 diabetes. The interplay of factors such as glycemic control, diabetic complications, and…
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Artikel Jurnal
Dermatological side effects of dipeptidyl Peptidase-4 inhibitors in diabetes management: a comprehensive review
Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of drugs that enhance the incretin-insulin pathway and offer effective glycemic control in type 2 diabetes mellitus. However, these drugs may be associated with various dermatological side effects, ranging from mild to severe. This…
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Artikel Jurnal
Thyroid storm with acute liver failure and disseminated intravascular coagulation- lessons in diagnosis and treatment
Abstract Thyroid storm is a medical emergency with a high mortality rate. Acute liver failure (ALF) and disseminated intravascular coagulation (DIC) are rarely reported with thyroid storm, and their occurrence is unrelated to the degree of free circulating thyroxine. We present the case of a…
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Artikel Jurnal
Treatment of glucocorticoid- induced hyperglycemia in hospitalized patients - a systematic review and meta- analysis
Abstract Purpose Glucocorticoid (GC)-induced hyperglycemia is a frequent issue, however there are no specific guidelines for this diabetes subtype. Although treat-to-target insulin is recommended in general to correct hyperglycemia, it remains unclear which treatment strategy has a positive effect…
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Artikel Jurnal
Efficacy and safety of fixed dose combination of Sitagliptin, metformin, and pioglitazone in type 2 Diabetes (IMPACT study): a randomized controlled trial
Abstract Background Due to the progressive decline in β-cell function, it is often necessary to utilize multiple agents with complementary mechanisms of action to address various facets and achieve glycemic control. Thus, this study aimed to evaluate the efficacy and safety of a fixed-dose…
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Artikel Jurnal
Sodium bicarbonate and intubation in severe diabetic ketoacidosis: are we too quick to dismiss them?
Abstract Management of diabetic ketoacidosis (DKA) has internationally established guidelines. However, management of severe, refractory DKA with multiple contributors to acidosis, and management of DKA in patients with altered mentation, remain ambiguous. Use of sodium bicarbonate and intubation…
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Artikel Jurnal
Effectiveness of a nurse-led management intervention on systolic blood pressure among type 2 diabetes patients in Uganda: a cluster randomized trial
Abstract Background Hypertension (HT) is an orchestrator of atherosclerotic cardiovascular disease (ASCVD) in people living with type 2 diabetes (T2D). Control of systolic blood pressure (SBP) and HT as a whole is suboptimal in diabetes, partly due to the scarcity of doctors. While nurse-led…
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Artikel Jurnal
Exploring the silent epidemic: investigating the hidden burden of normal weight obesity in type 2 Diabetes Mellitus in India - a cross-sectional study
Abstract Objective This study aimed to determine the prevalence of Normal Weight Obesity (NWO) and evaluate its association with cardiometabolic risk factors among patients with Type 2 Diabetes Mellitus (T2DM) in Gujarat, India. Methods This cross-sectional study included 432 adults with T2DM…
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Artikel Jurnal
Online diabetes self-management education application for reducing glycated hemoglobin level among patients with type 1 diabetes mellitus: a systematic review and meta-analysis
Abstract Background This meta-analysis study aims to evaluate the Diabetes Self-Management Education and Support (DSMES) online application for reducing glycated hemoglobin levels among patients with type 1 diabetes mellitus (T1DM) patients. Main text The Web of Science (WoS), Cochrane Library…
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Artikel Jurnal
Adjuvant local antibiotic therapy in the management of diabetic foot osteomyelitis
Abstract Background The management of diabetic foot osteomyelitis (DFO) is complex. The targeted use of adjuvant local antibiotics, in the form of biocomposite bone void filler, in DFO, can enhance patient outcomes while minimising the adverse effects associated with systemic antibiotic therapy and…
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Artikel Jurnal
A prospective, multicentre study evaluating safety and efficacy of a fixed dose combination of Remogliflozin etabonate, Vildagliptin, and Metformin in Indian patients with type 2 diabetes mellitus (Triad-RMV)
Abstract Aims The ICMR INDIAB-17 study revealed a diabetes prevalence of 11.4% in India, emphasizing the need for effective treatment for glycemic control. A Phase IV study was conducted to evaluate the safety and efficacy of a Fixed Dose Combination (FDC) of Remogliflozin, Metformin and…
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Artikel Jurnal
Propylthiouracil-induced vasculitis with alveolar hemorrhage after 31 years of treatment: a case report
Abstract Background Propylthiouracil is an antithyroid medication that is associated with ANCA positivity, often in the absence of clinically overt vasculitis. Propylthiouracil-induced ANCA-associated vasculitis (AAV) is characterized by multiple antigenicity and presents similarly to other forms…