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Cell Discovery
Scopus
ISSN 2056-5968 · Nature Publishing Group · 726 artikel di indeks
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Artikel Jurnal
Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases
Abstract Osteoclasts are bone-resorbing cells that play a central role in normal bone remodeling and contribute to bone loss associated with pathological conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, periodontal disease, and bone metastases of cancer. The commitment…
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Artikel Jurnal
IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration
Abstract Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo experiments, we first confirmed age-associated…
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Artikel Jurnal
ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression
Abstract S-palmitoylation, a reversible post-translational modification regulates protein stability and cellular functions, yet its role in glutamine metabolism remains unclear. Here, we show that ZDHHC14 as the key palmitoyltransferase catalyzing ASCT2 palmitoylation at conserved Cys39 and Cys48…
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Artikel Jurnal
Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC
Abstract Deciphering the spatial organization of cell states is fundamental for understanding development, tissue homeostasis and disease. Emerging advances in spatial transcriptomic profiling techniques allow transcript localization but face limitations in unambiguous cell state assignments due to…
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Artikel Jurnal
Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks
Abstract Neurotropic viruses invade neural tissues, resulting in severe diseases such as poliomyelitis, rabies, herpesviral encephalitis, and viral meningitis. Given this neurotropism, we investigated whether the infection of the host by these viruses is under circadian control. In this study, we…
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Artikel Jurnal
Palmitic acid activates c-Myc via dual palmitoylation-dependent pathways to promote colon cancer
Abstract c-Myc is broadly hyperactivated in colon cancer, yet the mechanisms sustaining its transcriptional activation remain elusive. Here we identify palmitic acid (PA) as a metabolite cue that activates c-Myc via dual palmitoylation-dependent pathways operating across tumor initiation and…
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Artikel Jurnal
Eggerthella lenta disrupts the gut vascular barrier to drive colorectal cancer liver metastasis
Abstract Distant metastasis is the leading cause of death in colorectal cancer (CRC), and the gut vascular barrier (GVB) is the first obstacle to hematogenous spread. To investigate whether GVB function is directly influenced by metastasis-associated bacteria, we analyzed two cohorts comprising 20…
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Artikel Jurnal
The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis
Abstract Beta-coronavirus infection disrupts endoplasmic reticulum (ER) homeostasis; however, the mechanisms by which viral proteins manipulate ER-resident factors remain unclear. Here, we report that the SARS-CoV-2 accessory protein ORF3a binds to the ER chloride channel CLCC1, thereby impairing…
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Artikel Jurnal
Top-down medial prefrontal cortex-to-hypothalamic paraventricular nucleus circuit regulates social avoidance and conditioned fear in male mice
Abstract Compromised cortical inhibition during threat processing contributes to individual vulnerability to stress-related psychiatric disorders. However, the precise underlying neurobiological circuits remain elusive. Here, by combining monosynaptic viral tracing, electrophysiology, in vivo…
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Artikel Jurnal
RNA helicase DDX6 governs ASC speck formation in P-bodies and the transition to stress granules via phase separation during inflammasome activation
Abstract The recruitment and condensation of apoptosis-associated speck-like protein containing a CARD (ASC) are critical for ASC speck formation and inflammasome activation. However, how this process occurs efficiently in vivo remains unclear. Here, we identified the RNA helicase DDX6 as an…
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Artikel Jurnal
Selective cellular localization of UHRF1 safeguards mammalian zygotic genome activation and early embryonic development
Abstract Zygotic genome activation (ZGA) is essential for initiating the developmental gene expression program in early embryos. However, whether a gating mechanism orchestrated by a limited number of factors exists in mammals remains debated. In this study, by utilizing an Nlrp14-deficient model…
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Artikel Jurnal
WAT-to-BAT communication facilitates the sustained activation of BAT thermogenesis during cold exposure
Abstract The activation of brown adipose tissue (BAT) for thermogenesis represents a crucial physiological mechanism that helps maintain body temperature during cold exposure. Nevertheless, the exact mechanisms underlying the sustained activation of BAT under cold conditions remain incompletely…
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Artikel Jurnal
HMMR+ stromal cells drive human uterine development
Abstract Early uterine development in humans is a critical determinant of reproductive health and disease susceptibility during adolescence. While single-cell analyses have extensively characterized the adult uterus, the developmental origins of this organ remain poorly understood. In this study…