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International Journal of Immunopathology and Pharmacology
Scopus
ISSN 2058-7384 · SAGE Publishing · 711 artikel di indeks
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Artikel Jurnal
Atypical cytokine release syndrome induced by carboplatin: The first described case report
Introduction Hypersensitivity reactions to carboplatin include type I reactions, mixed reactions, and delayed reactions. Case report We report a case of an atypical cytokine release syndrome induced by carboplatin in a patient with breast carcinoma. Management & outcome The patient developed…
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Artikel Jurnal
Beyond antibiotic prophylaxis: A scoping review of infective endocarditis prevention in the device era
Infective endocarditis (IE) remains a severe condition associated with significant morbidity and mortality. Dental procedures involving manipulation of gingival tissue or the periapical region may cause transient bacteremia, making prevention strategies at the dental–medical interface clinically…
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Artikel Jurnal
Integrated transcriptomic and immunogenomic analysis unravels the immunological functions and prognostic landscape of WD repeat domain 76
Background WD Repeat Domain 76 (WDR76) plays a potential role in cellular regulation; however, its comprehensive landscape across human malignancies and its specific biological function in hepatocellular carcinoma (HCC) remain largely unexplored. Methods We conducted a systematic pan-cancer…
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Artikel Jurnal
Oral keratinocyte-mediated inflammation and epithelial disruption: A narrative review on IRF6 signaling and oral carcinogenic risk
The oral epithelium is a dynamic interface between host and environment, where keratinocytes not only serve as structural components but also actively modulate immune responses. Emerging research identifies IRF6 as a pivotal regulator of epithelial differentiation and immune signaling within…
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Artikel Jurnal
Outcomes of isoniazid preventive therapy in pregnant women living with HIV: A systematic review and meta-analysis
Objective: To evaluate the safety and effectiveness of isoniazid preventive therapy (IPT) in pregnant women living with HIV (WLWH) through a systematic review and meta-analysis. Introduction: Isoniazid preventive therapy (IPT) is recommended for preventive treatment of tuberculosis in high risk…
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Artikel Jurnal
Nasopharyngeal mass containing B-cell small lymphocytic lymphoma in a human immunodeficiency virus-positive patient: A case report and review of the literature
The spectrum of pathological conditions affecting the nasopharynx includes infections, congenital anomalies, and tumoral lesions, particularly angiofibroma, nasopharyngeal carcinoma, and lymphoma. Hypertrophy of adenoid tissue is a frequent phenomenon in children, but it is less common in the adult…
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Artikel Jurnal
Agmatine suppresses the imidazoline I receptor/ribosomal S6 kinase 2/NF-κB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury
Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury characterized by damage to alveolar epithelial cells and pulmonary capillary endothelial cells. Compared with ARDS caused by other causes, the subtypes of ARDS caused by sepsis are more serious and lead to poor…
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Artikel Jurnal
Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets
Objective: To explore whether circulating plasma proteins have potential causal effects on gout risk by integrating genome-wide association study (GWAS) data with protein quantitative trait loci (pQTL) information, aiming to identify candidate proteins and pathways for therapeutic targeting…
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Artikel Jurnal
Apoptosis enhancement in MCF-7 cells: Synergistic effects of doxorubicin and the novel sulfonamide Zm-093
Introduction: Breast cancer (BC) is a major global health issue. Combination therapies using chemical compounds have shown potential benefits, including reduced toxicity, slowed cancer cell growth, and improved treatment outcomes, compared to single-drug treatments. Objectives: This study…
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Artikel Jurnal
Impact of hepatitis C virus on oral health: Clinical lesions, immunopathology, and dental management: A narrative review
Hepatitis C virus (HCV) infection is a major global public health problem. Although it has traditionally been linked to liver damage, several studies have demonstrated its extrahepatic impact, specifically in the oral cavity. Oral manifestations can be considered early signs of infection or…
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Artikel Jurnal
Primary epithelioid angiosarcoma of thyroid: A case report and review of literature
Epithelioid angiosarcoma (EA) is a malignant tumor of endothelium origin that most commonly arises in the deep soft tissues of extremities but may occasionally be primary in skin, adrenal gland, and bone. A 72-year-old male presented with a painless enlargement of his thyroid for more than 10 days…
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Artikel Jurnal
Silencing RPL9 promotes malignant proliferation in breast cancer cells
Objective: To identify key RNA-binding proteins (RBPs) associated with breast cancer (BRCA) prognosis and to construct an RBP-based prognostic scoring model and clinical nomogram. Additionally, to explore the functional role of RPL9 in BRCA cell proliferation and apoptosis. Introduction: Breast…
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Artikel Jurnal
Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells
Shikonin has been reported to regulate caudal-type homeobox 2 (CDX2)-mediated intestinal epithelial cell (IEC) differentiation, and ferroptosis has been identified a critical event during this process. However, the exact role of ferroptosis in shikonin-induced IEC differentiation remains unclear…
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Artikel Jurnal
Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats
Objective: Cannabidiol (CBD) administration (5 mg/kg) in healthy rats has been shown to significantly decrease lymphocyte subset numbers in peripheral blood without involvement of natural killer cells. The aim was to evaluate whether lymphocyte numbers also decrease in the spleen. Introduction…
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Artikel Jurnal
Glycolysis and neutrophil extracellular traps in atherosclerosis: Mechanisms, association, and therapeutic strategies
Atherosclerosis (AS) is a chronic inflammatory disorder of the medium and large arteries, characterized by lipid accumulation within the arterial wall and a sustained inflammatory milieu, and it remains a leading cause of cardiovascular morbidity and mortality worldwide. Glycolysis and neutrophil…
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Development of RNase P ribozyme-based therapy against oral herpesvirus infections by HSV-1 and KSHV
Infections with human herpesviruses are known to be associated with oral lesions and other oral complications. For example, herpes simplex virus 1 (HSV-1) is the causative agent for cold sores. Kaposi’s sarcoma-associated herpesvirus (KSHV) causes oral Kaposi’s sarcoma (KS) and other oral…
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Artikel Jurnal
Inflammatory and neuroinjury blood biomarkers across COVID-19 severity groups in individuals with persistent neurological symptoms
Persistent neurological symptoms such as cognitive impairment, fatigue, and neuropsychiatric disturbances are increasingly reported in patients with long COVID, with chronic neuroinflammation and neuronal injury proposed as potential contributors. To characterize inflammatory and…
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Artikel Jurnal
Liposomal nanotherapeutics for cancer treatment: Targeted delivery and immunotherapy
Cancer has become a major global health crisis and the second leading cause of death worldwide. With over 270 different types, it is estimated to claim 13 million lives by 2030. The complex pathophysiology of cancer, with its diverse genetic, epigenetic, and biochemical pathways, complicates the…