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European Journal of Inflammation
Scopus
ISSN 2058-7392 · SAGE Publishing · 1.142 artikel di indeks
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Artikel Jurnal
Early plasma exchange combined with triple-combination therapy may improve survival in patients with high mortality risk anti-MDA5-positive dermatomyositis-associated interstitial lung disease: A single-center retrospective observational study
Objective Anti-MDA5 antibody-positive dermatomyositis (MDA5-DM) frequently causes rapidly progressive interstitial lung disease (ILD) with poor prognosis. Although immunosuppressive therapies have advanced, outcomes remain unsatisfactory. Early plasma exchange (PE) has been suggested to improve…
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Artikel Jurnal
mmu-miR-1843b-5p negatively regulates EGR1 expression and modulates GM-CSF-differentiated macrophage activity in experimental autoimmune uveitis
Objective To investigate the relationship between mmu-miR-1843b-5p and EGR1 expression during GM-CSF-induced macrophage differentiation in experimental autoimmune uveitis (EAU). Methods Splenic mononuclear cells isolated from EAU mice were cultured with granulocyte-macrophage colony-stimulating…
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Artikel Jurnal
Exploring the mechanism of ursodeoxycholic acid in the treatment of osteoarthritis based on network pharmacology, molecular docking, and molecular dynamics simulations
Objectives Accumulating evidence suggests that ursodeoxycholic acid (UDCA) has therapeutic potential for osteoarthritis (OA); however, the underlying molecular mechanisms remain poorly understood. Methods The chemical components of UDCA were retrieved from PubChem. Potential UDCA targets were…
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Artikel Jurnal
Early changes in immune-inflammatory indices and healing outcomes in pressure injuries patients: A retrospective study
Background Early prediction of wound healing after flap reconstruction for stage IV pressure injuries remains challenging. This study evaluated the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) as predictors of healing outcomes. Methods This retrospective cohort…
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Artikel Jurnal
Role of neutrophil extracellular traps in myocardial infarction pathogenesis, diagnosis, and treatment
Cardiovascular Diseases (CVDs) still reign as the leading cause of mortality worldwide, with Myocardial Infarction (MI) being one of the most life-threatening manifestations. Mounting evidence highlights the critical role of inflammation, specifically neutrophil activity, in MI pathogenesis…
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Artikel Jurnal
Mendelian randomization study of the causal relationship between serum metabolites and ankylosing spondylitis risk
Background Although previous metabolomics studies have identified metabolic alterations in ankylosing spondylitis (AS), the causal relationship between circulating serum metabolites and disease risk remains unclear. To address this knowledge gap, we aimed to investigate these causal associations…
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Artikel Jurnal
Corylin alleviated lung injury and inflammatory response in a rat venoarterial extracorporeal membrane oxygenation model
Background Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is an essential life-saving technology used to treat refractory cardiopulmonary failure, commonly utilized in cases of cardiogenic shock, postoperative circulatory assistance, and resuscitation after cardiac arrest. While…
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Artikel Jurnal
To enhance the anti-aging and anti-inflammatory effect of bakuchiol and retinol by combining a tripeptide via the PPAR-γ signaling pathway
Objectives To prevent skin aging that induced by chronic inflammation and collagen depletion, along with the consequent decline in elasticity and wrinkles formation. Methods A novel formulation was developed to counter inflammatory and prevent collagen losing with low cytotoxicity to human foreskin…
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Artikel Jurnal
The role of Lyn in immunity and chronic inflammation: Implications for periodontitis
Lyn kinase, a critical immune regulator, is well-established in systemic autoimmune diseases, but its role in periodontitis remains unclear. This narrative review synthesizes literature up to July 2025 from PubMed, Scopus, and Web of Science to examine the immunoregulatory functions of Lyn and…
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Artikel Jurnal
Evidence for purinergic signaling pathways in human rheumatoid and osteoarthritis synovial tissue
Background Inflammatory joint destruction releases intracellular components like ATP and triggers an acidic microenvironment. Detection of ATP and ischemia by sensory neurons leads to pain sensation, but little is known about the presence of purinoceptors and regulating factors in synovial tissue…
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Artikel Jurnal
COVID-19 pathogenesis: Immune dynamics, inflammatory cascades, and therapeutic frontiers
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to global health. Understanding the complex molecular and cellular mechanisms underlying SARS-CoV-2 infection is critical for developing effective therapeutic strategies. This narrative review…
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Artikel Jurnal
The role of platelet in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifestations ranging from mild skin symptoms to severe organ and neurological involvement. Thrombosis is a major complication and leading cause of mortality, though its mechanisms remain unclear. Emerging evidence highlights…
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Artikel Jurnal
The RhoA/ROCK pathway in vascular dysfunction and inflammation: Mechanisms and therapeutic targeting
Cardiovascular diseases (CVDs) remain the foremost global cause of mortality, largely driven by endothelial dysfunction and vascular remodelling. The RhoA/Rho-associated coiled-coil containing protein kinase (ROCK) signalling pathway is central to vascular homeostasis, regulating vascular smooth…
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Artikel Jurnal
Menstrual disorders in systemic lupus erythematosus patients; A cross-sectional pilot study
Background: Persistent menstrual disorders are relatively common in patients with systemic lupus erythematosus (SLE). The purpose was to shed light on the causes and associations of menstrual disorders, particularly focusing on the potential influence of immunosuppressive medications. Patients and…
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Artikel Jurnal
Effects of vitamin D on the expression of GATA-3 and T-bet in the nasal mucosa of rats with allergic rhinitis
Objective To investigate the effects of vitamin D (VitD) on GATA-3 and T-bet expression in the nasal mucosa of allergic rhinitis (AR) rats and on regulation of the Th1/Th2 immune balance. Methods 24 rats were randomly categorized into Control, Model, and VitD groups (n = 8 per group). The Model and…
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Artikel Jurnal
Comparative liver proteomic analysis of protein expression changes in an acute-on-chronic liver failure mouse model
Purpose: Acute-on-chronic liver failure (ACLF) is a major cause of mortality and morbidity owing to the lack of targeted therapeutic interventions. The molecular mechanisms underlying the complex pathogenesis of ACLF are still unclear. Therefore, in this study, we established an ACLF mouse model…
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Artikel Jurnal
Activation of hydroxycarboxylic acid receptor 1 attenuates glutamate-induced excitotoxic neuronal injury
The aim of this study is to investigate the role of hydroxycarboxylic acid receptor 1 (HCAR1) in glutamate-induced excitotoxic neuronal injury. The effective and safe concentrations of an endogenous HCAR1 agonist (L-lactic acid) and an exogenous HCAR1 agonist (3,5-dihydroxybenzoic acid, 3,5-DHBA)…
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Artikel Jurnal
Mapping the influence of inflammatory cytokines on gout risk: Insights from a comprehensive bidirectional Mendelian randomization analysis
Background The relationship between gout pathogenesis and inflammatory cytokine alterations remains uncertain, with inconsistent findings across studies. This study evaluated the causal links between gout and 41 inflammatory cytokines using Mendelian randomization (MR). Methods Gout-related genetic…
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Artikel Jurnal
Comparative expression profiling of Portuguese and Turkish Behçet syndrome patients: Are we looking at the same Behçet?
Background: Behçet syndrome (BS) is a multisystemic inflammatory disorder with an obscure pathogenesis. Inconsistent, sometimes contrasting immunological findings observed in BS studies and considerable geographic variation in BS’s disease expression need explanation. This study compared the gene…
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